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Marine Drugs, Volume 16, Issue 8

2018 August - 43 articles

Cover Story: Prionace glauca is one the major bycatch species taken from driftnet fisheries every year generating a significant amount of biomass, considered waste for the fish transformation industry that needs to be managed and ultimately valorized. Exploring the potential of blue shark byproducts, as skins and teeth, 3D bioactive structures with a huge potential for biomedical applications were fabricated. Collagen extracted from the skin of Prionace glauca combined with bioceramic particles obtained from the tooth of Prionace glauca and Iurus oxyrinchus were combined and processed by freeze-drying to produce 3D structures as biomaterials aiming at hard tissue regeneration. Based on a strategy of marine byproducts valorization the produced collagen/apatite composites demonstrate the sustainability of the structures to support and promote osteogenic lineage survival. View the paper here.
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Articles (43)

  • Article
  • Open Access
51 Citations
5,817 Views
13 Pages

Perylenequione Derivatives with Anticancer Activities Isolated from the Marine Sponge-Derived Fungus, Alternaria sp. SCSIO41014

  • Xiaoyan Pang,
  • Xiuping Lin,
  • Pei Wang,
  • Xuefeng Zhou,
  • Bin Yang,
  • Junfeng Wang and
  • Yonghong Liu

14 August 2018

Seven new secondary metabolites classified as two perylenequinone derivatives (1 and 2), an altenusin derivative (3), two phthalide racemates (4 and 5), and two phenol derivatives (6 and 7), along with twenty-one known compounds (828) were iso...

  • Article
  • Open Access
27 Citations
5,998 Views
13 Pages

Cembranoid-Related Metabolites and Biological Activities from the Soft Coral Sinularia flexibilis

  • Chia-Hua Wu,
  • Chih-Hua Chao,
  • Tzu-Zin Huang,
  • Chiung-Yao Huang,
  • Tsong-Long Hwang,
  • Chang-Feng Dai and
  • Jyh-Horng Sheu

9 August 2018

Five new cembranoid-related diterpenoids, namely, flexibilisins D and E (1 and 2), secoflexibilisolides A and B (3 and 4), and flexibilisolide H (5), along with nine known compounds (614), were isolated from the soft coral Sinularia flexibilis...

  • Article
  • Open Access
88 Citations
7,870 Views
13 Pages

Green Synthesis of Gold Nanoparticles Using Carrageenan Oligosaccharide and Their In Vitro Antitumor Activity

  • Xiangyan Chen,
  • Xia Zhao,
  • Yanyun Gao,
  • Jiaqi Yin,
  • Mingyue Bai and
  • Fahe Wang

7 August 2018

Gold nanoparticles (AuNPs) have been widely used in catalysis, photothermal therapy, and targeted drug delivery. Carrageenan oligosaccharide (CAO) derived from marine red algae was used as a reducing and capping agent to obtain AuNPs by an eco-friend...

  • Article
  • Open Access
26 Citations
5,249 Views
9 Pages

6 August 2018

Fucoxanthin has an antiproliferative effect on cancer cells, but its detailed structure–activity correlation has not yet been elucidated. To elucidate this correlation, fucoxanthin was degraded by ozonolysis. The degraded compounds of fucoxanth...

  • Article
  • Open Access
26 Citations
5,453 Views
17 Pages

New Cembranoids and a Biscembranoid Peroxide from the Soft Coral Sarcophyton cherbonnieri

  • Chia-Chi Peng,
  • Chiung-Yao Huang,
  • Atallah F. Ahmed,
  • Tsong-Long Hwang,
  • Chang-Feng Dai and
  • Jyh-Horng Sheu

6 August 2018

Six new cembranoids, cherbonolides A−E (15) and bischerbolide peroxide (6), along with one known cembranoid, isosarcophine (7), were isolated from the Formosan soft coral Sarcophyton cherbonnieri. The structures of these compounds were elucidated by...

  • Article
  • Open Access
2 Citations
4,384 Views
8 Pages

4 August 2018

The production of secondary metabolites by a new isolate of the purple sulfur bacterium Allochromatium vinosum, which had shown antibiotic activities during a preliminary study, revealed the production of several metabolites. Growth conditions suitab...

  • Article
  • Open Access
52 Citations
6,802 Views
13 Pages

4 August 2018

Natural angiotensin converting enzyme (ACE)-inhibitory peptides, which are derived from marine products, are useful as antihypertensive drugs. Nevertheless, the activities of these natural peptides are relatively low, which limits their applications....

  • Article
  • Open Access
45 Citations
10,020 Views
16 Pages

Chemical Mutagenesis and Fluorescence-Based High-Throughput Screening for Enhanced Accumulation of Carotenoids in a Model Marine Diatom Phaeodactylum tricornutum

  • Zhiqian Yi,
  • Yixi Su,
  • Maonian Xu,
  • Andreas Bergmann,
  • Saevar Ingthorsson,
  • Ottar Rolfsson,
  • Kourosh Salehi-Ashtiani,
  • Sigurdur Brynjolfsson and
  • Weiqi Fu

4 August 2018

Diatoms are a major group of unicellular algae that are rich in lipids and carotenoids. However, sustained research efforts are needed to improve the strain performance for high product yields towards commercialization. In this study, we generated a...

  • Article
  • Open Access
44 Citations
5,511 Views
15 Pages

New Thiazole Nortopsentin Analogues Inhibit Bacterial Biofilm Formation

  • Anna Carbone,
  • Barbara Parrino,
  • Maria Grazia Cusimano,
  • Virginia Spanò,
  • Alessandra Montalbano,
  • Paola Barraja,
  • Domenico Schillaci,
  • Girolamo Cirrincione,
  • Patrizia Diana and
  • Stella Cascioferro

4 August 2018

New thiazole nortopsentin analogues were conveniently synthesized and evaluated for their activity as inhibitors of biofilm formation of relevant Gram-positive and Gram-negative pathogens. All compounds were able to interfere with the first step of b...

  • Review
  • Open Access
249 Citations
20,553 Views
25 Pages

Chitosan-Based Composite Materials for Prospective Hemostatic Applications

  • Zhang Hu,
  • Dong-Ying Zhang,
  • Si-Tong Lu,
  • Pu-Wang Li and
  • Si-Dong Li

4 August 2018

Effective hemostasis is vital to reduce the pain and mortality of patients, and the research and development of hemostatic materials are prerequisite for effective hemostasis. Chitosan (CS), with good biodegradability, biocompatibility and non-toxici...

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Mar. Drugs - ISSN 1660-3397