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Marine Drugs, Volume 16, Issue 6

June 2018 - 42 articles

Cover Story: Malaria has caused millions of deaths, and drug resistance against current treatments is rising; thus, new drugs directed to novel targets are urgently needed. An Australian study focused on underexplored ecological niches where ascidian-associated actinomycetes were isolated. By an approach utilizing HSQC-TOCSY NMR profiles and biological activity data, the scientists identified antiplasmodial polyketide-producing strains of actinomycetes. The extract obtained from an isolated Streptomyces sp. (USC-16018) exhibited 97% inhibition of Plasmodium falciparum at 0.2 μg/mL. Large-scale fermentation and subsequent purification of this culture resulted in the isolation of two polyketides, the new herbimycin G and the known elaiophylin, which both exhibited antiplasmodial activity. These findings stress the idea that actinomycetes are still an unexhausted source of new bioactive compounds.View this paper.
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Articles (42)

  • Communication
  • Open Access
40 Citations
7,225 Views
12 Pages

5 June 2018

We report on the isolation and characterization of an acid- and bile-tolerant bacterial strain, Bacillus sp. YB1701 with antibacterial and quorum-quenching activity. Strain YB1701 was isolated from coastal sediment samples and characterized by bioche...

  • Article
  • Open Access
19 Citations
5,095 Views
15 Pages

Daily Intake of Protein from Cod Residual Material Lowers Serum Concentrations of Nonesterified Fatty Acids in Overweight Healthy Adults: A Randomized Double-Blind Pilot Study

  • Iselin Vildmyren,
  • Huy John Vu Cao,
  • Lina Bowitz Haug,
  • Ida Ulrikke Valand,
  • Øyvin Eng,
  • Åge Oterhals,
  • Maren Hoff Austgulen,
  • Alfred Halstensen,
  • Gunnar Mellgren and
  • Oddrun A. Gudbrandsen

5 June 2018

Improved process technologies have allowed fishing vessels to utilize residuals from cod fillet production (head, backbone, skin, cuttings, and entrails) and convert this to high-quality protein powders for human consumption. In this double-blind pil...

  • Feature Paper
  • Article
  • Open Access
73 Citations
8,097 Views
16 Pages

Anti-Obesity Effect of Chitosan Oligosaccharide Capsules (COSCs) in Obese Rats by Ameliorating Leptin Resistance and Adipogenesis

  • Haitao Pan,
  • Chuhan Fu,
  • Lanlan Huang,
  • Yao Jiang,
  • Xiaoyi Deng,
  • Jiao Guo and
  • Zhengquan Su

5 June 2018

Obesity is a global disease that causes many metabolic disorders. However, effective agents for the prevention or treatment of obesity remain limited. This study investigated the anti-obesity effect and mechanism of chitosan oligosaccharide capsules...

  • Feature Paper
  • Article
  • Open Access
26 Citations
5,517 Views
14 Pages

Commercial Fucoidans from Fucus vesiculosus Can Be Grouped into Antiadipogenic and Adipogenic Agents

  • Ruth Medeiros Oliveira,
  • Rafael Barros Gomes Câmara,
  • Jessyka Fernanda Santiago Monte,
  • Rony Lucas Silva Viana,
  • Karoline Rachel Teodosio Melo,
  • Moacir Fernandes Queiroz,
  • Luciana Guimarães Alves Filgueira,
  • Lila Missae Oyama and
  • Hugo Alexandre Oliveira Rocha

4 June 2018

Fucus vesiculosus is a brown seaweed used in the treatment of obesity. This seaweed synthesizes various bioactive molecules, one of them being a sulfated polysaccharide known as fucoidan (FF). This polymer can easily be found commercially, and has an...

  • Review
  • Open Access
61 Citations
8,776 Views
36 Pages

Novel Natural Products from Extremophilic Fungi

  • Xuan Zhang,
  • Shou-Jie Li,
  • Jin-Jie Li,
  • Zi-Zhen Liang and
  • Chang-Qi Zhao

4 June 2018

Extremophilic fungi have been found to develop unique defences to survive extremes of pressure, temperature, salinity, desiccation, and pH, leading to the biosynthesis of novel natural products with diverse biological activities. The present review f...

  • Article
  • Open Access
5 Citations
4,777 Views
8 Pages

2 June 2018

A new 14-membered homodimeric macrodiolide, brevidiolide (3), along with four known aromatic compounds (1, 2, 4 and 5) were obtained by heterologous expression of the recombinant plasmid pWLI823 expressing the G231L variant of VioA in the marine-deri...

  • Communication
  • Open Access
20 Citations
6,454 Views
14 Pages

A Novel Atypical PKC-Iota Inhibitor, Echinochrome A, Enhances Cardiomyocyte Differentiation from Mouse Embryonic Stem Cells

  • Hyoung Kyu Kim,
  • Sung Woo Cho,
  • Hye Jin Heo,
  • Seung Hun Jeong,
  • Min Kim,
  • Kyung Soo Ko,
  • Byoung Doo Rhee,
  • Natalia P. Mishchenko,
  • Elena A. Vasileva and
  • Sergey A. Fedoreyev
  • + 2 authors

2 June 2018

Echinochrome A (EchA) is a marine bioproduct extracted from sea urchins having antioxidant, antimicrobial, anti-inflammatory, and chelating effects, and is the active component of the clinical drug histochrome. We investigated the potential use of Ec...

  • Article
  • Open Access
50 Citations
6,624 Views
13 Pages

1 June 2018

Violaxanthin is a major xanthophyll pigment in the microalga Eustigmatos cf. polyphem, but the amount produced after propagation can vary depending upon culture conditions. In this study, the effects of cultivation time, nitrogen concentration, light...

  • Article
  • Open Access
25 Citations
5,910 Views
11 Pages

HSQC-TOCSY Fingerprinting-Directed Discovery of Antiplasmodial Polyketides from the Marine Ascidian-Derived Streptomyces sp. (USC-16018)

  • Larissa Buedenbender,
  • Luke P. Robertson,
  • Leonardo Lucantoni,
  • Vicky M. Avery,
  • D. İpek Kurtböke and
  • Anthony R. Carroll

30 May 2018

Chemical investigations on the fermentation extract obtained from an ascidian-derived Streptomyces sp. (USC-16018) yielded a new ansamycin polyketide, herbimycin G (1), as well as a known macrocyclic polyketide, elaiophylin (2), and four known diketo...

  • Review
  • Open Access
148 Citations
12,812 Views
26 Pages

Phycotoxins in Marine Shellfish: Origin, Occurrence and Effects on Humans

  • Federica Farabegoli,
  • Lucía Blanco,
  • Laura P. Rodríguez,
  • Juan Manuel Vieites and
  • Ana García Cabado

29 May 2018

Massive phytoplankton proliferation, and the consequent release of toxic metabolites, can be responsible for seafood poisoning outbreaks: filter-feeding mollusks, such as shellfish, mussels, oysters or clams, can accumulate these toxins throughout th...

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Mar. Drugs - ISSN 1660-3397