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Marine Drugs, Volume 16, Issue 1

January 2018 - 38 articles

Cover Story: Aaptos is a genus of marine sponge which belongs to Suberitidae and distributed in the tropical and subtropical oceans. Aaptamine, demethyloxyaaptamine, and isoaaptamine were isolated from Aaptos sp. methanolic extract. In this study, we sought to elucidate the cytotoxic activity of aaptamine alkaloids in vitro along with their mechanism of action. The effect of IAp treatment on ROS generation and ER stress-related proteins in breast T-47D cancer cells was evaluated showing an enhancement in ROS generation as well as IRE 1α and Bip expression. Based on the results that ROS and ER stress are involved in IAp effect on T-47D cells, we hypothesized that the induction of apoptosis and autophagy might be attributed to mitochondrial dysfunction-dependent apoptosis and Nrf2/p62 dependent autophagy.
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Articles (38)

  • Review
  • Open Access
71 Citations
6,415 Views
16 Pages

Facial Bone Reconstruction Using both Marine or Non-Marine Bone Substitutes: Evaluation of Current Outcomes in a Systematic Literature Review

  • Marco Cicciù,
  • Gabriele Cervino,
  • Alan Scott Herford,
  • Fausto Famà,
  • Ennio Bramanti,
  • Luca Fiorillo,
  • Floriana Lauritano,
  • Sergio Sambataro,
  • Giuseppe Troiano and
  • Luigi Laino

13 January 2018

The aim of the present investigation was to systematically analyse the literature on the facial bone reconstruction defect using marine collagen or not and to evaluate a predictable treatment for their clinical management. The revision has been perfo...

  • Article
  • Open Access
37 Citations
7,060 Views
19 Pages

Evaluation of Rapid, Early Warning Approaches to Track Shellfish Toxins Associated with Dinophysis and Alexandrium Blooms

  • Theresa K. Hattenrath-Lehmann,
  • Mark W. Lusty,
  • Ryan B. Wallace,
  • Bennie Haynes,
  • Zhihong Wang,
  • Maggie Broadwater,
  • Jonathan R. Deeds,
  • Steve L. Morton,
  • William Hastback and
  • Leonora Porter
  • + 2 authors

13 January 2018

Marine biotoxin-contaminated seafood has caused thousands of poisonings worldwide this century. Given these threats, there is an increasing need for improved technologies that can be easily integrated into coastal monitoring programs. This study eval...

  • Article
  • Open Access
22 Citations
5,619 Views
13 Pages

Lipid-Lowering Polyketides from the Fungus Penicillium Steckii HDN13-279

  • Guihong Yu,
  • Shuai Wang,
  • Lu Wang,
  • Qian Che,
  • Tianjiao Zhu,
  • Guojian Zhang,
  • Qianqun Gu,
  • Peng Guo and
  • Dehai Li

12 January 2018

Seven new polyketides, named tanzawaic acids R–X (1–6, 11), along with seven known analogues (7–10 and 12–14), were isolated from Penicillium steckii HDN13-279. Their structures, including the absolute configurations, were elucidated by NMR, MS, X-ra...

  • Review
  • Open Access
416 Citations
19,507 Views
31 Pages

12 January 2018

Carotenoids are natural pigments that play pivotal roles in many physiological functions. The characteristics of carotenoids, their effects on health, and the cosmetic benefits of their usage have been under investigation for a long time; however, mo...

  • Article
  • Open Access
44 Citations
6,231 Views
18 Pages

11 January 2018

In this study, we extracted fucoidan from compressional-puffing-pretreated Sargassum crassifolium by hot water. The crude extract of fucoidan (SC) was degraded by various degradation reagents and four low-molecular-weight (LMW) fucoidans, namely SCO...

  • Article
  • Open Access
32 Citations
7,708 Views
21 Pages

11 January 2018

The nanocomposite of half-fin anchovy hydrolysates (HAHp) and zinc oxide nanoparticles (ZnO NPs) (named as HAHp(3.0)/ZnO NPs) demonstrated increased antibacterial activity compared to either HAHp(3.0) or ZnO NPs as per our previous studies. Also, rea...

  • Review
  • Open Access
17 Citations
8,041 Views
17 Pages

Sponges: A Reservoir of Genes Implicated in Human Cancer

  • Helena Ćetković,
  • Mirna Halasz and
  • Maja Herak Bosnar

10 January 2018

Recently, it was shown that the majority of genes linked to human diseases, such as cancer genes, evolved in two major evolutionary transitions—the emergence of unicellular organisms and the transition to multicellularity. Therefore, it has been wide...

  • Article
  • Open Access
29 Citations
6,929 Views
12 Pages

Posidonia oceanica (L.) Delile Ethanolic Extract Modulates Cell Activities with Skin Health Applications

  • Laura Cornara,
  • Giulia Pastorino,
  • Barbara Borghesi,
  • Annalisa Salis,
  • Marco Clericuzio,
  • Carla Marchetti,
  • Gianluca Damonte and
  • Bruno Burlando

10 January 2018

Seagrasses are high plants sharing adaptive metabolic features with both terrestrial plants and marine algae, resulting in a phytocomplex possibly endowed with interesting biological properties. The aim of this study is to evaluate the in vitro activ...

  • Article
  • Open Access
38 Citations
9,005 Views
14 Pages

Bacillibactin and Bacillomycin Analogues with Cytotoxicities against Human Cancer Cell Lines from Marine Bacillus sp. PKU-MA00093 and PKU-MA00092

  • Mengjie Zhou,
  • Fawang Liu,
  • Xiaoyan Yang,
  • Jing Jin,
  • Xin Dong,
  • Ke-Wu Zeng,
  • Dong Liu,
  • Yingtao Zhang,
  • Ming Ma and
  • Donghui Yang

10 January 2018

Nonribosomal peptides from marine Bacillus strains have received considerable attention for their complex structures and potent bioactivities. In this study, we carried out PCR-based genome mining for potential nonribosomal peptides producers from ou...

  • Article
  • Open Access
44 Citations
6,426 Views
13 Pages

The Bioactive Extract of Pinnigorgia sp. Induces Apoptosis of Hepatic Stellate Cells via ROS-ERK/JNK-Caspase-3 Signaling

  • Liang-Mou Kuo,
  • Po-Jen Chen,
  • Ping-Jyun Sung,
  • Yu-Chia Chang,
  • Chun-Ting Ho,
  • Yi-Hsiu Wu and
  • Tsong-Long Hwang

9 January 2018

The activation of hepatic stellate cells (HSCs) is a significant phenomenon during the pathogenesis of liver disorders, including liver cirrhosis and fibrosis. Here, we identified that the extract from a gorgonian coral Pinnigorgia sp. (Pin) induced...

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Mar. Drugs - ISSN 1660-3397