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Marine Drugs, Volume 16, Issue 1

January 2018 - 38 articles

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Cover Story: Aaptos is a genus of marine sponge which belongs to Suberitidae and distributed in the tropical and subtropical oceans. Aaptamine, demethyloxyaaptamine, and isoaaptamine were isolated from Aaptos sp. methanolic extract. In this study, we sought to elucidate the cytotoxic activity of aaptamine alkaloids in vitro along with their mechanism of action. The effect of IAp treatment on ROS generation and ER stress-related proteins in breast T-47D cancer cells was evaluated showing an enhancement in ROS generation as well as IRE 1α and Bip expression. Based on the results that ROS and ER stress are involved in IAp effect on T-47D cells, we hypothesized that the induction of apoptosis and autophagy might be attributed to mitochondrial dysfunction-dependent apoptosis and Nrf2/p62 dependent autophagy.

Articles (38)

  • Article
  • Open Access
75 Citations
14,072 Views
13 Pages

A Rapid Method for the Determination of Fucoxanthin in Diatom

  • Li-Juan Wang,
  • Yong Fan,
  • Ronald L. Parsons,
  • Guang-Rong Hu,
  • Pei-Yu Zhang and
  • Fu-Li Li

22 January 2018

Fucoxanthin is a natural pigment found in microalgae, especially diatoms and Chrysophyta. Recently, it has been shown to have anti-inflammatory, anti-tumor, and anti-obesityactivity in humans. Phaeodactylum tricornutum is a diatom with high economic...

  • Article
  • Open Access
20 Citations
6,449 Views
11 Pages

19 January 2018

Polyclad flatworms comprise a highly diverse and cosmopolitan group of marine turbellarians. Although some species of the genera Planocera and Stylochoplana are known to be tetrodotoxin (TTX)-bearing, there are few new reports. In this study, planoce...

  • Article
  • Open Access
27 Citations
5,560 Views
29 Pages

19 January 2018

Twenty-nine new limonoids—named xylomolins A1–A7, B1–B2, C1–C2, D–F, G1–G5, H–I, J1–J2, K1–K2, L1–L2, and M–N, were isolated from the seeds of the mangrove plant, Xylocarpus moluccensis. Compounds 1–13 are mexicanolides with one double bond or two co...

  • Article
  • Open Access
53 Citations
8,209 Views
15 Pages

Anti-Phytopathogenic and Cytotoxic Activities of Crude Extracts and Secondary Metabolites of Marine-Derived Fungi

  • Dong-Lin Zhao,
  • Dan Wang,
  • Xue-Ying Tian,
  • Fei Cao,
  • Yi-Qiang Li and
  • Cheng-Sheng Zhang

18 January 2018

Thirty-one isolates belonging to eight genera in seven orders were identified from 141 strains that were isolated from several marine plants. Alternaria sp. and Fusarium sp. were found to be the predominant fungi. Evaluation of the anti-phytopathogen...

  • Article
  • Open Access
88 Citations
9,146 Views
11 Pages

17 January 2018

The microbial degradation behavior of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHHx) and its compound with several polyesters such as poly(butylene adipate-co-telephtharate) (PBAT), poly(butylene succinate) (PBS), and polylactic acid (PLA) in...

  • Article
  • Open Access
34 Citations
6,802 Views
16 Pages

Specific Molecular Signatures for Type II Crustins in Penaeid Shrimp Uncovered by the Identification of Crustin-Like Antimicrobial Peptides in Litopenaeus vannamei

  • Cairé Barreto,
  • Jaqueline Da Rosa Coelho,
  • Jianbo Yuan,
  • Jianhai Xiang,
  • Luciane Maria Perazzolo and
  • Rafael Diego Rosa

16 January 2018

Crustins form a large family of antimicrobial peptides (AMPs) in crustaceans composed of four sub-groups (Types I-IV). Type II crustins (Type IIa or “Crustins” and Type IIb or “Crustin-like”) possess a typical hydrophobic N-terminal region and are by...

  • Article
  • Open Access
13 Citations
5,440 Views
15 Pages

Low Molecular Weight Chitosan-Insulin Complexes Solubilized in a Mixture of Self-Assembled Labrosol and Plurol Oleaque and Their Glucose Reduction Activity in Rats

  • Amani M. Elsayed,
  • Aseel H. Khaled,
  • Mayyas M. Al Remawi,
  • Nidal A. Qinna,
  • Hussam Abu Farsakh and
  • Adnan A. Badwan

16 January 2018

Oral insulin delivery that better mimics physiological pathways is a necessity as it ensures patient comfort and compliance. A system which is based on a vehicle of nano order where positively charged chitosan interacts with negatively charged insuli...

  • Article
  • Open Access
48 Citations
5,925 Views
12 Pages

Characterization of a Novel Alginate Lyase from Marine Bacterium Vibrio furnissii H1

  • Xiaoyan Zhu,
  • Xiangqian Li,
  • Hao Shi,
  • Jia Zhou,
  • Zhongbiao Tan,
  • Mengdi Yuan,
  • Peng Yao and
  • Xiaoyan Liu

15 January 2018

Alginate lyases show great potential for industrial and medicinal applications, especially as an attractive biocatalyst for the production of oligosaccharides with special bioactivities. A novel alginate lyase, AlyH1, from the marine bacterium Vibrio...

  • Article
  • Open Access
75 Citations
7,486 Views
12 Pages

Optimization of Extraction Conditions and Characterization of Pepsin-Solubilised Collagen from Skin of Giant Croaker (Nibea japonica)

  • Fangmiao Yu,
  • Chuhong Zong,
  • Shujie Jin,
  • Jiawen Zheng,
  • Nan Chen,
  • Ju Huang,
  • Yan Chen,
  • Fangfang Huang,
  • Zuisu Yang and
  • Yunping Tang
  • + 1 author

14 January 2018

In the present study, response surface methodology was performed to investigate the effects of extraction parameters on pepsin-solubilised collagen (PSC) from the skin of the giant croaker Nibea japonica. The optimum extraction conditions of PSC were...

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Mar. Drugs - ISSN 1660-3397Creative Common CC BY license