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Current Issues in Molecular Biology, Volume 46, Issue 6

June 2024 - 74 articles

Cover Story: Multiple Sclerosis (MS) is the most common demyelinating disease of the central nervous system. MS development and progression depend on the perpetuation of chronic inflammation and high oxidative stress production, which are attributable to several factors, such as infections, an unhealthy diet, autoimmune responses, genetic predisposition, and gut microbiota alterations. In recent years, several studies suggest supplementing traditional treatments with the use of bioactive molecules (e.g., ubiquinone, resveratrol, curcumin, epigallocatechin gallate, citicoline, ellagic acid, boswellic acid, and plant extracts) and dietary interventions (Mediterranean vs. ketogenic) that, acting as antioxidants and anti-inflammatory agents, can help counteract neuroinflammation and oxidative damage. View this paper
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Articles (74)

  • Article
  • Open Access
4 Citations
1,558 Views
16 Pages

Dracocephalum moldavica is widely used as an ornamental, medicine, and perfume in industry. Real-time fluorescence quantitative polymerase chain reaction (RT-qPCR) is widely and accurately utilized for gene expression evaluations. Selecting optimal r...

  • Article
  • Open Access
2 Citations
1,505 Views
17 Pages

Low Levels of IgM Recognizing 4-Hydroxy-2-Nonenal-Modified Apolipoprotein A-I Peptide and Its Association with the Severity of Coronary Artery Disease in Taiwanese Patients

  • Meng-Huan Lei,
  • Po-Wen Hsu,
  • Yin-Tai Tsai,
  • Chen-Chi Chang,
  • I-Jung Tsai,
  • Hung Hsu,
  • Ming-Hui Cheng,
  • Ying-Li Huang,
  • Hung-Tse Lin and
  • Yu-Cheng Hsu
  • + 1 author

Autoantibodies against apolipoprotein A-I (ApoA-I) are associated with cardiovascular disease risks. We aimed to examine the 4-hydroxy-2-nonenal (HNE) modification of ApoA-I in coronary artery disease (CAD) and evaluate the potential risk of autoanti...

  • Review
  • Open Access
10 Citations
4,225 Views
19 Pages

Omics approaches have significantly contributed to our understanding of several aspects of chicken reproduction. This review paper gives an overview of the use of omics technologies such as genomics, transcriptomics, proteomics, and metabolomics to e...

  • Article
  • Open Access
6 Citations
4,419 Views
11 Pages

SRSF3 Knockdown Inhibits Lipopolysaccharide-Induced Inflammatory Response in Macrophages

  • Yu Fu,
  • Yanjing Wang,
  • Luyao Zhang,
  • Tianliu He,
  • Weiye Shi,
  • Xueling Guo and
  • Yingze Wang

Serine/arginine-rich splicing factor 3 (SRSF3), the smallest member of the SR protein family, serves multiple roles in RNA processing, including splicing, translation, and stability. Recent studies have shown that SRSF3 is implicated in several infla...

  • Article
  • Open Access
4 Citations
2,613 Views
14 Pages

Oxytocin Exhibits Neuroprotective Effects on Hippocampal Cultures under Severe Oxygen–Glucose Deprivation Conditions

  • Mara Ioana Ionescu,
  • Ioana-Florentina Grigoras,
  • Rosana-Bristena Ionescu,
  • Diana Maria Chitimus,
  • Robert Mihai Haret,
  • Bogdan Ianosi,
  • Mihai Ceanga and
  • Ana-Maria Zagrean

Perinatal asphyxia (PA) and hypoxic-ischemic encephalopathy can result in severe, long-lasting neurological deficits. In vitro models, such as oxygen–glucose deprivation (OGD), are used experimentally to investigate neuronal response to metabol...

  • Article
  • Open Access
8 Citations
3,910 Views
24 Pages

Bioinformatics Analysis Reveals E6 and E7 of HPV 16 Regulate Metabolic Reprogramming in Cervical Cancer, Head and Neck Cancer, and Colorectal Cancer through the PHD2-VHL-CUL2-ELOC-HIF-1α Axis

  • Adán Arizmendi-Izazaga,
  • Napoleón Navarro-Tito,
  • Hilda Jiménez-Wences,
  • Adilene Evaristo-Priego,
  • Víctor Daniel Priego-Hernández,
  • Roberto Dircio-Maldonado,
  • Ana Elvira Zacapala-Gómez,
  • Miguel Ángel Mendoza-Catalán,
  • Berenice Illades-Aguiar and
  • Mónica Ascención De Nova Ocampo
  • + 3 authors

Human papillomavirus 16 (HPV 16) infection is associated with several types of cancer, such as head and neck, cervical, anal, and penile cancer. Its oncogenic potential is due to the ability of the E6 and E7 oncoproteins to promote alterations associ...

  • Article
  • Open Access
1 Citations
1,729 Views
13 Pages

Structure and Phylogenetic Relationships of Scolopacidae Mitogenomes (Charadriiformes: Scolopacidae)

  • Quanheng Li,
  • Peiyue Jiang,
  • Mingxuan Li,
  • Jingjing Du,
  • Jianxiang Sun,
  • Nuo Chen,
  • Yu Wu,
  • Qing Chang and
  • Chaochao Hu

The family Scolopacidae presents a valuable subject for evolutionary research; however, molecular studies of Scolopacidae are still relatively understudied, and the phylogenetic relationships of certain species remain unclear. In this study, we seque...

  • Article
  • Open Access
1 Citations
4,364 Views
17 Pages

Molecular Approaches Detect Early Signals of Programmed Cell Death in Hippolyte inermis Leach

  • Francesca Glaviano,
  • Roberta Esposito,
  • Emanuele Somma,
  • Amir Sagi,
  • Eliahu D. Aflalo,
  • Maria Costantini and
  • Valerio Zupo

The protandric shrimp Hippolyte inermis is the only known marine invertebrate whose sex determination is strongly influenced by the composition of its food. In H. inermis, a sex reversal is triggered by the ingestion of diatoms of the genus Cocconeis...

  • Review
  • Open Access
6 Citations
4,609 Views
30 Pages

Molecular Biomarkers of Canine Reproductive Functions

  • Marzena Mogielnicka-Brzozowska and
  • Aleksandra Wiktoria Cichowska

The aim of the current study is to review potential molecular biomarker substances selected so far as useful for assessing the quality of dog semen. Proteins, lipids, carbohydrates, and ions can serve as molecular biomarkers of reproductive functions...

  • Article
  • Open Access
1 Citations
3,073 Views
18 Pages

Antidepressant Effect of Enzymatic Porcine Placenta Hydrolysate in Repeated Immobilization Stress-Induced Ovariectomized Female Mice

  • Minsook Ye,
  • Sharon Nguyen,
  • Min Ju Kim,
  • Jee Sun Hwang,
  • Gun Won Bae,
  • Keun-Hang Susan Yang and
  • Insop Shim

When postmenopausal women are under stress conditions, this exacerbates mood disorders and issues with neuroimmune systems. The porcine placenta is known to relieve menopausal depression in clinical trials, but its underlying mechanisms for depressio...

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Curr. Issues Mol. Biol. - ISSN 1467-3045