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Review

Gene Regulatory Mechanism of Mycobacterium Tuberculosis during Dormancy

by
Yiduo Liu
1,2,†,
Han Li
1,†,
Dejia Dai
1,
Jiakang He
1,* and
Zhengmin Liang
1,*
1
College of Animal Science and Technology, Guangxi University, No. 100 University West Road, Nanning 530004, China
2
College of Veterinary Medicine, China Agricultural University, Beijing 100193, China
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Curr. Issues Mol. Biol. 2024, 46(6), 5825-5844; https://doi.org/10.3390/cimb46060348 (registering DOI)
Submission received: 10 April 2024 / Revised: 5 June 2024 / Accepted: 7 June 2024 / Published: 11 June 2024
(This article belongs to the Collection Feature Papers Collection in Molecular Microbiology)

Abstract

Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb) complex, is a zoonotic disease that remains one of the leading causes of death worldwide. Latent tuberculosis infection reactivation is a challenging obstacle to eradicating TB globally. Understanding the gene regulatory network of Mtb during dormancy is important. This review discusses up-to-date information about TB gene regulatory networks during dormancy, focusing on the regulation of lipid and energy metabolism, dormancy survival regulator (DosR), White B-like (Wbl) family, Toxin-Antitoxin (TA) systems, sigma factors, and MprAB. We outline the progress in vaccine and drug development associated with Mtb dormancy.
Keywords: latent tuberculosis infection; dormancy; regulatory mechanism; vaccines latent tuberculosis infection; dormancy; regulatory mechanism; vaccines

Share and Cite

MDPI and ACS Style

Liu, Y.; Li, H.; Dai, D.; He, J.; Liang, Z. Gene Regulatory Mechanism of Mycobacterium Tuberculosis during Dormancy. Curr. Issues Mol. Biol. 2024, 46, 5825-5844. https://doi.org/10.3390/cimb46060348

AMA Style

Liu Y, Li H, Dai D, He J, Liang Z. Gene Regulatory Mechanism of Mycobacterium Tuberculosis during Dormancy. Current Issues in Molecular Biology. 2024; 46(6):5825-5844. https://doi.org/10.3390/cimb46060348

Chicago/Turabian Style

Liu, Yiduo, Han Li, Dejia Dai, Jiakang He, and Zhengmin Liang. 2024. "Gene Regulatory Mechanism of Mycobacterium Tuberculosis during Dormancy" Current Issues in Molecular Biology 46, no. 6: 5825-5844. https://doi.org/10.3390/cimb46060348

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