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Pharmaceuticals, Volume 13, Issue 10

October 2020 - 64 articles

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Cover Story: This paper describes how novel anti-EGFR antibody-drug conjugates (ABT-414, ABBV-221, and ABBV-321) that selectively target a tumor-selective (mAb806) epitope were evaluated for the treatment of malignant mesothelioma. EGFR and mAb806 epitope expression in malignant mesothelioma cell lines was confirmed using in vitro assays. Biodistribution and imaging studies demonstrated specific targeting of malignant mesothelioma tumors using an 89Zr-labeled immunoconjugate-ch806. In vivo therapy studies were conducted in malignant mesothelioma xenograft and PDX tumor models. ABT-414, ABBV-221, and ABBV-322 resulted in significant growth inhibition in tumors with high EGFR and mAb806 epitope expression. In contrast, in an EGFR expressing PDX model that was negative for the mAb806 epitope, no growth inhibition was observed. View this paper.

Articles (64)

  • Article
  • Open Access
16 Citations
4,325 Views
28 Pages

Novel Sulfonamide-Based Analogs of Metformin Exert Promising Anti-Coagulant Effects without Compromising Glucose-Lowering Activity

  • Magdalena Markowicz-Piasecka,
  • Adrianna Sadkowska,
  • Joanna Sikora,
  • Marlena Broncel and
  • Kristiina M. Huttunen

21 October 2020

Metformin, one of the most frequently prescribed oral anti-diabetic drugs, is characterized by multidirectional activity, including lipid lowering, cardio-protective and anti-inflammatory properties. This study presents synthesis and stability studie...

  • Article
  • Open Access
28 Citations
6,474 Views
20 Pages

Learnings from Regional Market Dynamics of Originator and Biosimilar Infliximab and Etanercept in Germany

  • Evelien Moorkens,
  • Teresa Barcina Lacosta,
  • Arnold G. Vulto,
  • Martin Schulz,
  • Gabriele Gradl,
  • Salka Enners,
  • Gisbert Selke,
  • Isabelle Huys and
  • Steven Simoens

21 October 2020

Drug budget and prescription control measures are implemented regionally in Germany, meaning that the uptake of pharmaceuticals, including biosimilars, can vary by region. We examine regional market dynamics of tumor necrosis factor alpha (TNFα...

  • Communication
  • Open Access
14 Citations
7,516 Views
10 Pages

21 October 2020

Bipolar disorder is a chronic and remitting mental illness. Antidepressants are not effective in treating acute bipolar depression, and antipsychotic drugs used in the treatment of bipolar depression cause frequent side effects. This situation justif...

  • Article
  • Open Access
28 Citations
6,110 Views
19 Pages

Cardiotoxicity Associated with Gemcitabine: Literature Review and a Pharmacovigilance Study

  • Marc Hilmi,
  • Stéphane Ederhy,
  • Xavier Waintraub,
  • Christian Funck-Brentano,
  • Ariel Cohen,
  • Aurore Vozy,
  • Bénédicte Lebrun-Vignes,
  • Javid Moslehi,
  • Lee S. Nguyen and
  • Joe-Elie Salem

21 October 2020

Background: Gemcitabine is a nucleoside analog, widely used either alone or in combination, for the treatment of multiple cancers. However, gemcitabine may also be associated with cardiovascular adverse-drug-reactions (CV-ADR). Methods: First, we sea...

  • Article
  • Open Access
13 Citations
4,147 Views
13 Pages

Reversal of Ovarian Cancer Cell Lines Multidrug Resistance Phenotype by the Association of Apiole with Chemotherapies

  • Carolina Afonso de Lima,
  • Ian Lucas de Souza Bueno,
  • Stanley Nunes Siqueira Vasconcelos,
  • Juliana Mozer Sciani,
  • Ana Lúcia Tasca Gois Ruiz,
  • Mary Ann Foglio,
  • João Ernesto de Carvalho and
  • Giovanna Barbarini Longato

21 October 2020

Multidrug resistance (MDR) is the main obstacle in anticancer therapy. The use of drug combinations to circumvent tumor resistance is a well-established principle in the clinic. Among the therapeutic targets, glycoprotein-P (P-gp), an energy-dependen...

  • Feature Paper
  • Article
  • Open Access
7 Citations
3,221 Views
9 Pages

Antiarrhythmic Effect of Ranolazine in Combination with Selective NCX-Inhibition in an Experimental Model of Atrial Fibrillation

  • Julian Wolfes,
  • Christian Ellermann,
  • Niklas Broer,
  • Benjamin Rath,
  • Kevin Willy,
  • Patrick Robert Leitz,
  • Philipp Sebastian Lange,
  • Lars Eckardt and
  • Gerrit Frommeyer

20 October 2020

The aim of this study was to investigate the effects of a combination of ranolazine with different selective inhibitors of the Na+/Ca2+-exchanger (NCX) in an established experimental model of atrial fibrillation (AF). Eighteen hearts of New Zealand w...

  • Feature Paper
  • Review
  • Open Access
14 Citations
4,006 Views
22 Pages

20 October 2020

Stress exposure represents a major environmental risk factor for schizophrenia and other psychiatric disorders, as it plays a pivotal role in the etiology as well as in the manifestation of disease symptomatology. It may be inferred that pharmacologi...

  • Article
  • Open Access
21 Citations
5,253 Views
18 Pages

Attenuation of Spatial Memory in 5xFAD Mice by Halting Cholinesterases, Oxidative Stress and Neuroinflammation Using a Cyclopentanone Derivative

  • Rahim Ullah,
  • Gowhar Ali,
  • Nisar Ahmad,
  • Muhammad Akram,
  • Geeta Kumari,
  • Muhammad Usman Amin and
  • Muhammad Naveed Umar

19 October 2020

Alzheimer’s disease (AD) is an irreversible and chronic neurological disorder that gradually destroys memory and thinking skills. The research study was designed to investigate the underlying molecular signaling involved in the neuroprotective...

  • Review
  • Open Access
29 Citations
4,889 Views
25 Pages

19 October 2020

Exosomes are phospholipid-based particles endogenously produced by both normal and tumor cells. Initially identified as a pathway for shuttling cellular waste, for a long time they were thought to act as “garbage bags”, and only in the pa...

  • Article
  • Open Access
15 Citations
3,978 Views
24 Pages

Impact of Washingtonia robusta Leaves on Gamma Irradiation-Induced Hepatotoxicity in Rats and Correlation with STING Pathway and Phenolic Composition

  • Nabil M. Selim,
  • Seham S. El-Hawary,
  • Soheir M. El Zalabani,
  • Rehab Nabil Shamma,
  • Nariman El Sayed Mahdy,
  • Noheir H. Sherif,
  • Hanan A. Fahmy,
  • Mai H. Mekkawy,
  • Abdelaziz Yasri and
  • Mansour Sobeh

19 October 2020

Exposure to ionizing radiation usually results in cellular oxidative damage and may induce liver toxicity. The efficiency of the ethanol extracts of Washingtonia filifera (EWF) and Washingtonia robusta (EWR) leaves in alleviating γ-radiation-induced...

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