Special Issue "Multi-Component Delivery Systems for Targeted Delivery of Nucleic Acids"
Deadline for manuscript submissions: closed (18 June 2021).
Approaches to RNA interference have made a significant impact on research strategies and methodologies since the turn of the century. These approaches include but are not limited to plasmid DNA, small interfering RNA (siRNA), short hairpin RNA (shRNA), micro RNA (miRNA), oligonucleotides, and most recently, clustered regularly interspaced short palindromic repeats (CRISPR). Each approach offers certain advantages, and of course, has its own flaws. These approaches have provided reliable tools in basic and translational research, with the ability to target virtually any protein in a variety of mammalian cells and “silence” the expression of the target for a short period of time or permanently. However, despite promising initial results, this significant impact has not been translated into the wide clinical applications for which we all have hoped. Nucleic acid delivery is difficult, and has proven to be even more challenging in vivo. We have not given up yet. We are still exploring new approaches and novel carriers on a regular basis. This Special Issue aims to include review and research papers that provide a comprehensive look at the most recent attempts in nucleic acid delivery, focusing on multi-component delivery systems designed as safe and effective carriers. It is also hoped to shine light on the future directions for nucleic acid delivery.
Dr. Hamidreza Montazeri Aliabadi
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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- targeted delivery
- RNA interference
- in vitro
- in vivo