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Volume 13
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10.3390/ph13100304
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Article

Antibacterial Drug-Release Polydimethylsiloxane Coating for 3D-Printing Dental Polymer: Surface Alterations and Antimicrobial Effects

by
Hang-Nga Mai
1,†,
Dong Choon Hyun
2,†,
Ju Hayng Park
2,
Do-Yeon Kim
3,
Sang Min Lee
3 and
Du-Hyeong Lee
1,4,*
1
Institute for Translational Research in Dentistry, Kyungpook National University, Daegu 41940, Korea
2
Department of Polymer Science and Engineering, Kyungpook National University, Daegu 41566, Korea
3
Department of Pharmacology, School of Dentistry, Kyungpook National University, Daegu 41940, Korea
4
Department of Prosthodontics, School of Dentistry, Kyungpook National University, Daegu 41940, Korea
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Pharmaceuticals 2020, 13(10), 304; https://doi.org/10.3390/ph13100304
Submission received: 4 September 2020 / Revised: 30 September 2020 / Accepted: 10 October 2020 / Published: 12 October 2020
(This article belongs to the Special Issue Novel Antibacterial Agents)
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Abstract

Polymers are the most commonly used material for three-dimensional (3D) printing in dentistry; however, the high porosity and water absorptiveness of the material adversely influence biofilm formation on the surface of the 3D-printed dental prostheses. This study evaluated the effects of a newly developed chlorhexidine (CHX)-loaded polydimethylsiloxane (PDMS)-based coating material on the surface microstructure, surface wettability and antibacterial activity of 3D-printing dental polymer. First, mesoporous silica nanoparticles (MSN) were used to encapsulate CHX, and the combination was added to PDMS to synthesize the antibacterial agent-releasing coating substance. Then, a thin coating film was formed on the 3D-printing polymer specimens using oxygen plasma and thermal treatment. The results show that using the coating substance significantly reduced the surface irregularity and increased the hydrophobicity of the specimens. Remarkably, the culture media containing coated specimens had a significantly lower number of bacterial colony formation units than the noncoated specimens, thereby indicating the effective antibacterial activity of the coating.
Keywords: 3D-printing; dental polymer; antibacterial agent; coating; mesoporous silica nanoparticles; polydimethylsiloxane 3D-printing; dental polymer; antibacterial agent; coating; mesoporous silica nanoparticles; polydimethylsiloxane
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MDPI and ACS Style

Mai, H.-N.; Hyun, D.C.; Park, J.H.; Kim, D.-Y.; Lee, S.M.; Lee, D.-H. Antibacterial Drug-Release Polydimethylsiloxane Coating for 3D-Printing Dental Polymer: Surface Alterations and Antimicrobial Effects. Pharmaceuticals 2020, 13, 304. https://doi.org/10.3390/ph13100304

AMA Style

Mai H-N, Hyun DC, Park JH, Kim D-Y, Lee SM, Lee D-H. Antibacterial Drug-Release Polydimethylsiloxane Coating for 3D-Printing Dental Polymer: Surface Alterations and Antimicrobial Effects. Pharmaceuticals. 2020; 13(10):304. https://doi.org/10.3390/ph13100304

Chicago/Turabian Style

Mai, Hang-Nga, Dong Choon Hyun, Ju Hayng Park, Do-Yeon Kim, Sang Min Lee, and Du-Hyeong Lee. 2020. "Antibacterial Drug-Release Polydimethylsiloxane Coating for 3D-Printing Dental Polymer: Surface Alterations and Antimicrobial Effects" Pharmaceuticals 13, no. 10: 304. https://doi.org/10.3390/ph13100304

APA Style

Mai, H.-N., Hyun, D. C., Park, J. H., Kim, D.-Y., Lee, S. M., & Lee, D.-H. (2020). Antibacterial Drug-Release Polydimethylsiloxane Coating for 3D-Printing Dental Polymer: Surface Alterations and Antimicrobial Effects. Pharmaceuticals, 13(10), 304. https://doi.org/10.3390/ph13100304

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