Table of Contents
Int. J. Mol. Sci., Volume 16, Issue 5 (May 2015) , Pages 9037-11833
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Cover Story Anti-N-methyl-D-aspartate receptor subunit NR2A/B (anti-NR2A/B) antibodies are produced [...] Read more. Anti-N-methyl-D-aspartate receptor subunit NR2A/B (anti-NR2A/B) antibodies are produced extrathecally and must cross the blood–brain barrier (BBB) into the cerebrospinal fluid to influence brain function. Matrix metalloproteinase-9 is released by prestimulated low-density granulocytes, leading to the degradation of basal lamina and compromise of the BBB integrity. Anti-NR2A/B antibodies activate the BBB with increased expression of endothelial cell adhesion molecules, facilitating the recruitment, rolling, adhesion and transmigration of neutrophils, leading to further "NETosis" intrathecally. Lastly, the intrathecal release of neutrophil extracellular traps contributes to neurotoxicity by inducing neuronal cell death which subsequently leads to neuropsychiatric manifestations of systemic lupus erythematosus. View the article.