Table of Contents
Int. J. Mol. Sci., Volume 16, Issue 6 (June 2015) , Pages 11834-14290
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Cover Story ER-mitochondrial contact sites play important roles during autophagy. In particular, they provide [...] Read more. ER-mitochondrial contact sites play important roles during autophagy. In particular, they provide platforms for the assembly of the early autophagy machinery, and regulate autophagosome signaling and assembly through calcium signaling and lipid exchange. Parallel siRNA screens for factors involved in ER/mitochondrial dynamics and connectivity revealed that different regulators of calcium exchange contribute to autophagy (SigmaR1) and mitophagy (IP3Rs) responses in RPE1 cells. The contributions these and other candidates to autophagy and mitophagy are explored. View the article.