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Open AccessArticle

Genetic Variant rs10757278 on Chromosome 9p21 Contributes to Myocardial Infarction Susceptibility

1
The First Hospital of Harbin, Harbin 150070, Heilongjiang, China
2
The Department of Internal Circulation, the Second People's Hospital of Mudanjiang, Mudanjiang 157013, Heilongjiang, China
3
Department of Gastrointestinal Medical Oncology, the Affiliated Tumor Hospital of Harbin Medical University, Harbin 150081, Heilongjiang, China
4
Genome Analysis Laboratory, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China
5
Department of Cardiology, the Fourth Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang, China
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Gabor Csanyi
Int. J. Mol. Sci. 2015, 16(5), 11678-11688; https://doi.org/10.3390/ijms160511678
Received: 17 March 2015 / Revised: 4 May 2015 / Accepted: 14 May 2015 / Published: 21 May 2015
(This article belongs to the Section Biochemistry)
Large-scale genome-wide association studies (GWAS) have revealed that rs10757278 polymorphism (or its proxy rs1333049) on chromosome 9p21 is associated with myocardial infarction (MI) susceptibility in individuals of Caucasian ancestry. Following studies in other populations investigated this association. However, some of these studies reported weak or no significant association. Here, we reevaluated this association using large-scale samples by searching PubMed and Google Scholar databases. Our results showed significant association between rs10757278 polymorphism and MI with p = 6.09 × 10−22, odds ratio (OR) = 1.29, 95% confidence interval (CI) 1.22–1.36 in pooled population. We further performed a subgroup analysis, and found significant association between rs10757278 polymorphism and MI in Asian and Caucasian populations. We identified that the association between rs10757278 polymorphism and MI did not vary substantially by excluding any one study. However, the heterogeneity among the selected studies varies substantially by excluding the study from the Pakistan population. We found even more significant association between rs10757278 polymorphism and MI in pooled population, p = 3.55 × 10−53, after excluding the study from the Pakistan population. In summary, previous studies reported weak or no significant association between rs10757278 polymorphism and MI. Interestingly, our analysis suggests that rs10757278 polymorphism is significantly associated with MI susceptibility by analyzing large-scale samples. View Full-Text
Keywords: myocardial infarction; rs10757278; meta-analysis myocardial infarction; rs10757278; meta-analysis
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Chen, G.; Fu, X.; Wang, G.; Liu, G.; Bai, X. Genetic Variant rs10757278 on Chromosome 9p21 Contributes to Myocardial Infarction Susceptibility. Int. J. Mol. Sci. 2015, 16, 11678-11688.

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