Molecules, Volume 7, Issue 1

The nucleophilic substitution of substituted o-nitrochlorobenzenes with substituted methanethiolates, catalysed with triethylamine or pyridine, has been used to prepare a series of appropriately substituted methyl-o-nitrophenylsulfides. The prepared...

Methods for the preparation of 4-bromo-5-[2-(4-hydroxybenzyl)benzyl]-2-methoxyphenol and 4-bromo-5-[4-(4-hydroxyphenyl)butyl]-2-methoxyphenol are described.

The structure and shape of the polypeptide chains of proteins are determined by the hybridized states of the atomic orbitals in the molecular chain. The calculated s ratio in the spn hybrid orbitals is computed from the fractal dimension D of the ter...

An EtOAc extract of the stem bark of Calophyllum caledonicum (Clusiaceae) yielded thirteen new hydroxylated and/or prenylated xanthone derivatives, namely 5-hydroxy-8-methoxyxanthone (1), 3,5-dihydroxy-1,2-dimethoxyxanthone (2), 1,8-dihydroxy-6,7-dim...

Virtual screening (VS) methods have emerged as an adaptive response to massive throughput synthesis and screening technologies. Based on the structure-permeability paradigm, the Lipinski rule of five has become a standard property filtering protocol...

Stereospecific formation of spirodioxolanes has been observed on electron transfer induced ring opening of α-epoxyketones by 2,4,6-triphenylpyrylium tetrafluoroborate in the presence of cyclohexanone

A three-component reaction between an aldehyde, metallated hexamethyldisilazane and a functionalized organozinc compound proceeded smoothly in the presence of LiClO4 in diethyl ether to afford primary amino esters in good yields.

Nudibranchs are shell-less molluscs that are often brightly colored and seemingly defenseless against predation. However, these beautiful animals usually contain large amounts of diet-derived natural products that help defend them against predation....

Three compounds were isolated from the butanol soluble fraction of the resinous exudate from the stem of Eucalyptus maculata. In addition to p-coumaric acid two new compounds were identified. They were identified as 1-O-cinnamoyl 6-O-pcoumaroylglucos...

Wittig-Horner reagents 1a,b react with 1,2,3-indantrione (2) to give the dimeric adducts 3a and 3b, respectively. Moreover, 2 reacts with tert-butyl diethylphosphonoacetate (1c) yielding the ethylenic compound 4. On the other hand, 2 reacts with 1d t...