Skip Content
You are currently on the new version of our website. Access the old version .

31 Results Found

  • Article
  • Open Access
1 Citations
2,391 Views
16 Pages

Conditioning Electrical Nerve Stimulation Enhances Functional Rewiring in a Mouse Model of Nerve Transfer to Treat Chronic Spinal Cord Injury

  • Juan Sebastián Jara,
  • Marwa A. Soliman,
  • Amanda Bernstein,
  • Paola di Grazia,
  • Adam R. Ferguson,
  • Justin M. Brown,
  • Abel Torres-Espín and
  • Edmund R. Hollis

27 February 2025

Background/Objectives: Nerve transfer surgery is a state-of-the-art surgical approach to restore hand and arm function in individuals living with tetraplegia, significantly impacting daily life. While nearly a third of all individuals with chronic sp...

  • Article
  • Open Access
8 Citations
7,229 Views
13 Pages

Morphology of Donor and Recipient Nerves Utilised in Nerve Transfers to Restore Upper Limb Function in Cervical Spinal Cord Injury

  • Aurora Messina,
  • Natasha Van Zyl,
  • Michael Weymouth,
  • Stephen Flood,
  • Andrew Nunn,
  • Catherine Cooper,
  • Jodie Hahn and
  • Mary P. Galea

27 September 2016

Loss of hand function after cervical spinal cord injury (SCI) impacts heavily on independence. Multiple nerve transfer surgery has been applied successfully after cervical SCI to restore critical arm and hand functions, and the outcome depends on ner...

  • Communication
  • Open Access
2,859 Views
18 Pages

A Novel Passive Implantable Differential Mechanism to Restore Individuated Finger Flexion during Grasping following Tendon Transfer Surgery: A Pilot Study

  • Suraj Chakravarthi Raja,
  • Won Suk You,
  • Kian Jalaleddini,
  • Justin C. Casebier,
  • Nina R. Lightdale-Miric,
  • Vincent R. Hentz,
  • Francisco J. Valero-Cuevas and
  • Ravi Balasubramanian

8 May 2023

Tendon transfer surgery is often used to restore hand grasp function following high median-ulnar nerve palsy. This surgery typically reroutes and sutures the tendon of the extensor carpi radialis longus (ECRL) muscle to all four flexor digitorum prof...

  • Review
  • Open Access
17 Citations
7,728 Views
8 Pages

29 July 2021

Ischemic stroke remains a major cause of disability in the United States and worldwide. Following the large-scale implementation of stroke thrombectomy and the optimization of treatment protocols for acute stroke, the reduction in stroke-associated m...

  • Project Report
  • Open Access
2 Citations
2,067 Views
9 Pages

7 December 2023

Adding robotic surgery to bionic reconstruction might open a new dimension. The objective was to evaluate if a robotically harvested rectus abdominis (RA) transplant is a feasible procedure to improve soft-tissue coverage at the residual limb (RL) an...

  • Article
  • Open Access
3 Citations
2,942 Views
12 Pages

4 December 2024

Background: Damage to the upper trunk of the brachial plexus, often caused by high-energy trauma, leads to significant functional impairment of the upper limb. This injury primarily affects the C5 and C6 roots, resulting in paralysis of muscles criti...

  • Review
  • Open Access
19 Citations
3,981 Views
11 Pages

Adipose Tissue Uses in Peripheral Nerve Surgery

  • Allison Podsednik,
  • Raysa Cabrejo and
  • Joseph Rosen

Currently, many different techniques exist for the surgical repair of peripheral nerves. The degree of injury dictates the repair and, depending on the defect or injury of the peripheral nerve, plastic surgeons can perform nerve repairs, grafts, and...

  • Article
  • Open Access
2 Citations
4,817 Views
14 Pages

Results of Tendon Transfers in Radial Nerve Palsies: A New Evaluation Protocol

  • Micaela Reina,
  • Simonetta Odella,
  • Mauro Magnani,
  • Francesco Locatelli,
  • Alice Clemente,
  • Martina Macrì and
  • Pierluigi Tos

16 July 2024

Radial nerve palsies present a challenging clinical scenario, often leading to substantial functional impairment. This study focuses on evaluating the outcomes of tendon transfer surgeries in patients with post-traumatic radial nerve injuries. The ra...

  • Review
  • Open Access
14 Citations
4,759 Views
14 Pages

Advances in Modern Microsurgery

  • Oliver C. Thamm,
  • Johannes Eschborn,
  • Ruth C. Schäfer and
  • Jeremias Schmidt

6 September 2024

Background/Objectives: Microsurgery employs techniques requiring optical magnification and specialized instruments to operate on small anatomical structures, including small vessels. These methods are integral to plastic surgery, enabling procedures...

  • Article
  • Open Access
816 Views
10 Pages

20 October 2025

Background: Obstetrical brachial plexus palsy (OBPP) often results in medial shoulder contracture, with limited abduction and external rotation due to muscle imbalance and joint deformities. Late nerve transfers, such as spinal accessory nerve (SAN)...

  • Review
  • Open Access
1,066 Views
12 Pages

Management of Facial Paralysis Following Skull Base Surgery: A Comprehensive Narrative Review

  • Laura Maria De Luca,
  • Sergio Cannova,
  • Sebastiana Lai,
  • Marco Accolla,
  • Alice Barbazza,
  • Lea Calò,
  • Davide Rizzo,
  • Pierangela Tramaloni,
  • Marco Bonali and
  • Francesco Bussu
  • + 1 author

12 November 2025

Objectives: Facial paralysis is a devastating yet frequent complication of skull base surgery, significantly impacting quality of life through functional impairments and psychosocial consequences. Management is complex and requires an individualized...

  • Brief Report
  • Open Access
3 Citations
1,560 Views
7 Pages

4 September 2024

Purpose: Extensive lesions of the brachial plexus, or late cases, require free functional muscle grafts because the expected recovery time exceeds the critical threshold of 1.5 years, beyond which irreversible damage may be expected in the distal ner...

  • Review
  • Open Access
19 Citations
10,337 Views
54 Pages

Injured peripheral nerves regenerate their axons in contrast to those in the central nervous system. Yet, functional recovery after surgical repair is often disappointing. The basis for poor recovery is progressive deterioration with time and distanc...

  • Case Report
  • Open Access
8 Citations
3,747 Views
11 Pages

Reanimation of the Smile with Neuro-Vascular Anastomosed Gracilis Muscle: A Case Series

  • Helen Abing,
  • Carina Pick,
  • Tabea Steffens,
  • Jenny Shachi Sharma,
  • Jens Peter Klußmann and
  • Maria Grosheva

Background: The aim of our manuscript was to evaluate the time course of clinical and electromyographical (EMG) reinnervation after the reanimation of the smile using a gracilis muscle transplant which is reinnervated with the masseteric nerve. Metho...

  • Review
  • Open Access
3 Citations
3,892 Views
11 Pages

22 August 2024

Purpose: Facial paralysis results from congenital or acquired facial nerve damage, leading to significant cosmetic and functional deficits. Surgical resection of parotid and midface tumors can cause facial paralysis, necessitating effective treatment...

  • Article
  • Open Access
5 Citations
3,158 Views
14 Pages

Validation of a Cleanroom Compliant Sonication-Based Decellularization Technique: A New Concept in Nerve Allograft Production

  • Federico Bolognesi,
  • Nicola Fazio,
  • Filippo Boriani,
  • Viscardo Paolo Fabbri,
  • Davide Gravina,
  • Francesca Alice Pedrini,
  • Nicoletta Zini,
  • Michelina Greco,
  • Michela Paolucci and
  • Claudio Marchetti
  • + 5 authors

28 January 2022

Defects of the peripheral nervous system are extremely frequent in trauma and surgeries and have high socioeconomic costs. If the direct suture of a lesion is not possible, i.e., nerve gap > 2 cm, it is necessary to use grafts. While the gold stan...

  • Article
  • Open Access
2 Citations
2,366 Views
13 Pages

Phrenic Nerve Transfer to Musculocutaneous Nerve: An Anatomical and Histological Study

  • Alexandra Fochtmann-Frana,
  • Bettina Pretterklieber,
  • Christine Radtke and
  • Michael L. Pretterklieber

11 September 2023

Background: To restore elbow flexor muscle function in case of traumatic brachial plexus avulsion, the phrenic nerve transfer to the musculocutaneous nerve has become part of clinical practice. The nerve transfer can be done by means of video-assiste...

  • Case Report
  • Open Access
20 Citations
7,530 Views
8 Pages

Intraneural Platelet-Rich Plasma Injections for the Treatment of Radial Nerve Section: A Case Report

  • Unai García de Cortázar,
  • Sabino Padilla,
  • Enrique Lobato,
  • Diego Delgado and
  • Mikel Sánchez

29 January 2018

The radial nerve is the most frequently injured nerve in the upper extremity. Numerous options in treatment have been described for radial nerve injury, such as neurolysis, nerve grafts, or tendon transfers. Currently, new treatment options are arisi...

  • Article
  • Open Access
13 Citations
4,515 Views
19 Pages

Human Multipotent Mesenchymal Stromal Cell–Derived Extracellular Vesicles Enhance Neuroregeneration in a Rat Model of Sciatic Nerve Crush Injury

  • Svetlana V. Demyanenko,
  • Maria A. Pitinova,
  • Yulia N. Kalyuzhnaya,
  • Andrey M. Khaitin,
  • Svetlana A. Batalshchikova,
  • Natalya M. Dobaeva,
  • Yulia A. Shevtsova,
  • Kirill V. Goryunov,
  • Egor Y. Plotnikov and
  • Denis N. Silachev
  • + 2 authors

Peripheral nerve injury remains a serious problem for medicine, with no effective method of treatment at the moment. The most prominent example of this problem is neonatal brachial plexus palsy, which results from the stretching of the brachial plexu...

  • Review
  • Open Access
25 Citations
4,965 Views
26 Pages

Applications of Stem Cell-Derived Extracellular Vesicles in Nerve Regeneration

  • Burcak Yavuz,
  • Esra Cansever Mutlu,
  • Zubair Ahmed,
  • Besim Ben-Nissan and
  • Artemis Stamboulis

Extracellular vesicles (EVs), including exosomes, microvesicles, and other lipid vesicles derived from cells, play a pivotal role in intercellular communication by transferring information between cells. EVs secreted by progenitor and stem cells have...

  • Review
  • Open Access
23 Citations
8,270 Views
22 Pages

Corneal Neurotization—Indications, Surgical Techniques and Outcomes

  • Diana Carmen Dragnea,
  • Iva Krolo,
  • Carina Koppen,
  • Callum Faris,
  • Bert Van den Bogerd and
  • Sorcha Ní Dhubhghaill

13 March 2023

Corneal neurotization is a promising surgical approach for the treatment of moderate to severe neurotrophic keratopathy. This technique aims to restore corneal sensation by transferring healthy nerves, either directly or via a conduit, to the anesthe...

  • Article
  • Open Access
2 Citations
2,459 Views
12 Pages

23 February 2023

Cervical spinal cord injury (SCI) causing tetraplegia is extremely disabling. In such circumstances, restoration of upper extremity (UE) function is considered the highest priority. The advent of early nerve transfer (NT) procedures, in addition to m...

  • Article
  • Open Access
4 Citations
2,970 Views
30 Pages

Background and Objectives: Microsurgical resection with intraoperative neuromonitoring is the gold standard for acoustic neurinomas (ANs) which are classified as T3 or T4 tumors according to the Hannover Classification. Microscope-based augmented rea...

  • Article
  • Open Access
11 Citations
3,986 Views
17 Pages

Neuroprotective Effects of Sigma 1 Receptor Ligands on Motoneuron Death after Spinal Root Injury in Mice

  • Núria Gaja-Capdevila,
  • Neus Hernández,
  • Daniel Zamanillo,
  • Jose Miguel Vela,
  • Manuel Merlos,
  • Xavier Navarro and
  • Mireia Herrando-Grabulosa

Loss of motor neurons (MNs) after spinal root injury is a drawback limiting the recovery after palliative surgery by nerve or muscle transfers. Research based on preventing MN death is a hallmark to improve the perspectives of recovery following seve...

  • Article
  • Open Access
1 Citations
3,143 Views
9 Pages

Minimally Invasive Peroneal Tenodesis Assisted by Peroneal Tendoscopy: Technique and Preliminary Results

  • Rodrigo Simões Castilho,
  • João Murilo Brandão Magalhães,
  • Bruno Peliz Machado Veríssimo,
  • Carlo Perisano,
  • Tommaso Greco and
  • Roberto Zambelli

5 January 2024

Introduction: Peroneal disorders are a common cause of ankle pain and lateral instability and have been described in as much as 77% of patients with lateral ankle instability. Clicking, swelling, pain, and tenderness in the peroneal tendons track are...

  • Article
  • Open Access
2 Citations
2,829 Views
10 Pages

A continuous interscalene brachial plexus block (CIBPB) is usually administered before surgery in awake patients. However, the use of CIBPB before surgery could hinder the identification of nerve injuries after total shoulder arthroplasty (TSA). This...

  • Article
  • Open Access
1 Citations
3,433 Views
14 Pages

Smile Reanimation with Masseteric-to-Facial Nerve Transfer plus Cross-Face Nerve Grafting in Patients with Segmental Midface Paresis: 3D Retrospective Quantitative Evaluation

  • Filippo Tarabbia,
  • Filippo Bertozzi,
  • Fabiana Allevi,
  • Giovanni Dell’Aversana Orabona,
  • Silvia Cupello,
  • Claudia Dolci,
  • Matteo Zago,
  • Chiarella Sforza and
  • Federico Biglioli

5 December 2022

Facial paresis involves functional and aesthetic problems with altered and asymmetric movement patterns. Surgical procedures and physical therapy can effectively reanimate the muscles. From our database, 10 patients (18–50 years) suffering from...

  • Article
  • Open Access
5 Citations
4,440 Views
11 Pages

Donor-site Morbidity after Retromolar Bone Harvesting Using a Standardised Press Fit Cylinder Protocol

  • Philipp Streckbein,
  • Mathias Meier,
  • Christopher Kähling,
  • Jan-Falco Wilbrand,
  • Tobias Langguth,
  • Heidrun Schaaf,
  • Hans-Peter Howaldt,
  • Roland Streckbein and
  • Sameh Attia

19 November 2019

Precise fitting and immobilisation of bone transplants at the recipient site is of utmost importance for the healing process. With the help of the standardised Osseo Transfer System, the recipient site is adjusted to the graft, rather than vice versa...

  • Article
  • Open Access
2 Citations
6,947 Views
18 Pages

Lip Reconstruction by Double Layer and Double Flap New Combination Technique: A Case Series

  • Antonio Cortese,
  • Salvatore Catalano,
  • Antonio Alberto Maria Giunta,
  • Antonio Borri,
  • Daniele Panetta and
  • Pier Paolo Claudio

27 January 2022

In the past, lip reconstruction after ablative surgery has been performed by primary closure and more recently by free flap transfer technique. Cheek’s skin flap has been used to reconstruct the lower lip cutaneous portion. This study presents...

  • Article
  • Open Access
4 Citations
1,587 Views
12 Pages

Optimizing Outcomes in Mangled Lower Extremity Reconstruction: Insights from a Retrospective Study of 93 Patients and Their Functional Scores

  • Serdar Düzgün,
  • Mehmet Taner Özdemir,
  • Nurettin Manti,
  • Nuri Koray Ülgen and
  • Mehmet Orçun Akkurt

21 February 2025

Background/Objectives: Over the past 25 years, reconstructive techniques and patient management advancements have significantly improved outcomes in mangled lower extremity injuries. Functional results of limb salvage have been demonstrated to surpas...

  • Communication
  • Open Access
2 Citations
2,846 Views
10 Pages

Clinic-Electrophysiologic Correlations in Rehabilitation of Adult Patients with Traumatic Brachial Plexus Lesions

  • Dan Trofin,
  • Daniela-Viorelia Matei,
  • Daniela Marilena Trofin,
  • Ilie Onu,
  • Daniel Andrei Iordan and
  • Teodor Stamate

5 May 2023

Nerve-transfer surgery is the treatment of choice for traumatic brachial plexus injuries (tBPIs). Combined electromyography (EMG) follow-ups and results obtained by transcranial magnetic stimulation (TMS) may provide useful follow-up of rehabilitatio...