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Article

12 Citations

3,841 Views

14 Pages

Novel Mutation in the Acetohydroxyacid Synthase (AHAS), Gene Confers Imidazolinone Resistance in Chickpea Cicer arietinum L. Plants

Shmuel Galili,
Joseph Hershenhorn,
Marvin Edelman,
Vladimir Sobolev,
Evgeny Smirnov,
Orit Amir-Segev,
Aharon Bellalou and
Evgenia Dor

Plants2021, 10(12), 2791;https://doi.org/10.3390/plants10122791

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16 December 2021

Chickpea (Cicer arietinum L.) is an important crop in crop-rotation management in Israel. Imidazolinone herbicides have a wide spectrum of weed control, but chickpea plants are sensitive to acetohydroxyacid synthase (AHAS; also known as acetolactate...

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Article

2 Citations

1,685 Views

17 Pages

Cloning, Expression, Enzymatic Characterization and Mechanistic Studies of M13 Mutant Acetohydroxyacid Synthase That Rescues Valine Feedback Inhibition

Yaqing Tan,
Xingxing Gao,
Zhiqiang An,
Nan Wang,
Yaqian Ma and
Hailing Zhang

Fermentation2024, 10(6), 311;https://doi.org/10.3390/fermentation10060311

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12 June 2024

Acetohydroxyacid synthase (AHAS) is a key enzyme in the first step of the branched-chain amino acid synthesis pathway, and the production of acetohydroxybutyrate from one molecule of 2-ketobutyric acid and one molecule of pyruvate. AHAS is inhibited...

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Article

4 Citations

4,608 Views

16 Pages

Engineering Herbicide-Tolerance Rice Expressing an Acetohydroxyacid Synthase with a Single Amino Acid Deletion

Jun Fang,,
Changzhao Wan,
Wei Wang,
Liuyin Ma,
Xinqi Wang,
Can Cheng,
Jihua Zhou,
Yongjin Qiao and
Xiao Wang

Int. J. Mol. Sci.2020, 21(4), 1265;https://doi.org/10.3390/ijms21041265

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13 February 2020

The acetohydroxyacid synthase (AHAS) is an essential enzyme involved in branched amino acids. Several herbicides wither weeds via inhibiting AHAS activity, and the AHAS mutants show tolerance to these herbicides. However, most AHAS mutations are resi...

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Article

3 Citations

1,900 Views

16 Pages

Discovery of a New Class of Lipophilic Pyrimidine-Biphenyl Herbicides Using an Integrated Experimental-Computational Approach

Yitao Yan,
Yinglu Chen,
Hanxian Hu,
Youwei Jiang,
Zhengzhong Kang and
Jun Wu

Molecules2024, 29(11), 2409;https://doi.org/10.3390/molecules29112409

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21 May 2024

Herbicides are useful tools for managing weeds and promoting food production and sustainable agriculture. In this study, we report on the development of a novel class of lipophilic pyrimidine-biphenyl (PMB) herbicides. Firstly, three PMBs, Ia, IIa, a...

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Article

8 Citations

3,418 Views

18 Pages

Inheritance and Molecular Characterization of a Novel Mutated AHAS Gene Responsible for the Resistance of AHAS-Inhibiting Herbicides in Rapeseed (Brassica napus L.)

Qianxin Huang,
Jinyang Lv,
Yanyan Sun,
Hongmei Wang,
Yuan Guo,
Gaoping Qu and
Shengwu Hu

Int. J. Mol. Sci.2020, 21(4), 1345;https://doi.org/10.3390/ijms21041345

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17 February 2020

The use of herbicides is an effective and economic way to control weeds, but their availability for rapeseed is limited due to the shortage of herbicide-resistant cultivars in China. The single-point mutation in the acetohydroxyacid synthase (AHAS) g...

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Article

3 Citations

4,315 Views

14 Pages

Total Synthesis of the Antimycobacterial Natural Product Chlorflavonin and Analogs via a Late-Stage Ruthenium(II)-Catalyzed ortho-C(sp²)-H-Hydroxylation

Alexander Berger,
Talea Knak,
Anna-Lene Kiffe-Delf,
Korana Mudrovcic,
Vinayak Singh,
Mathew Njoroge,
Bjoern B. Burckhardt,
Mohanraj Gopalswamy,
Beate Lungerich and
Thomas Kurz
+ 4 authors

Pharmaceuticals2022, 15(8), 984;https://doi.org/10.3390/ph15080984

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10 August 2022

The continuous, worldwide spread of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB) endanger the World Health Organization’s (WHO) goal to end the global TB pandemic by the year 2035. During the past 50 years, v...

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Article

2 Citations

3,238 Views

10 Pages

Pro197Thr Substitution in Ahas Gene Causing Resistance to Pyroxsulam Herbicide in Rigid Ryegrass (Lolium Rigidum Gaud.)

Barbara Kutasy,
Zsolt Takács,
Judit Kovács,
Verëlindë Bogaj,
Syafiq A. Razak,
Géza Hegedűs,
Kincső Decsi,
Kinga Székvári and
Eszter Virág

Sustainability2021, 13(12), 6648;https://doi.org/10.3390/su13126648

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10 June 2021

Lolium rigidum Gaud. is a cross-pollinated species characterized by high genetic diversity and it was detected as one of the most herbicide resistance-prone weeds, globally. Acetohydroxyacid synthase (AHAS) resistant populations cause significant pro...

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Article

6 Citations

4,115 Views

16 Pages

Detection of Target-Site Herbicide Resistance in the Common Ragweed: Nucleotide Polymorphism Genotyping by Targeted Amplicon Sequencing

Barbara Kutasy,
Zoltán Farkas,
Balázs Kolics,
Kincső Decsi,
Géza Hegedűs,
Judit Kovács,
János Taller,
Zoltán Tóth,
Nikoletta Kálmán and
Eszter Virág
+ 1 author

Diversity2021, 13(3), 118;https://doi.org/10.3390/d13030118

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10 March 2021

Background: The spread of herbicide-resistance Ambrosia artemisiifolia threatens not only the production of agricultural crops, but also the composition of weed communities. The reduction of their spread would positively affect the biodiversity and b...

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Article

5 Citations

2,859 Views

13 Pages

Asymmetric Synthesis of Trifluoroethyl-Based, Chiral 3-Benzyloxy-1- and -2-Phenyl-quinazolinones of Biomedicinal Interest by Radical Type Cross-Coupling to Olefins

Chien-Tien Chen,
Yu-Chang Chang,
Pin-Xuan Tseng,
Chien-I Lein,
Shiang-Fu Hung and
Hsyueh-Liang Wu

Int. J. Mol. Sci.2023, 24(1), 513;https://doi.org/10.3390/ijms24010513

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28 December 2022

Several 2-substituted (H, Ph, and S-Me) and 1-substituted (H, Ph, and Bn), 3-hydroxy-1,3-quinazolin(di)ones were utilized for the first time as radical trapping agents in asymmetric 1,2-oxytrifluoromethylation of styrenes catalyzed by chiral vanadyl...

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Article

2 Citations

945 Views

18 Pages

Exploring the Potential of Genista ulicina Phytochemicals as Natural Biocontrol Agents: A Comparative In Vitro and In Silico Analysis

Roukia Zatout,
Ouided Benslama,
Fatima Zohra Makhlouf,
Alessio Cimmino,
Maria Michela Salvatore,
Anna Andolfi,
Radhia Manel Kolla and
Marco Masi

Toxins2025, 17(9), 452;https://doi.org/10.3390/toxins17090452

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6 September 2025

Development of new sustainable pesticides represents a real challenge for researchers due to environmental issues and public health aspects. In fact, the overuse of chemical pesticides has led to environmental damage, loss of biodiversity, and pestic...

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Article

6 Citations

3,662 Views

14 Pages

Novel Sulfonylurea Derivatives as Potential Antimicrobial Agents: Chemical Synthesis, Biological Evaluation, and Computational Study

Fan-Fei Meng,
Ming-Hao Shang,
Wei Wei,
Zhen-Wu Yu,
Jun-Lian Liu,
Zheng-Ming Li,
Zhong-Wen Wang,
Jian-Guo Wang and
Huan-Qin Dai

Antibiotics2023, 12(2), 323;https://doi.org/10.3390/antibiotics12020323

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3 February 2023

Methicillin-resistant Staphylococcus aureus (MRSA) is a worldwide health threat and has already tormented humanity during its long history, creating an urgent need for the development of new classes of antibacterial agents. In this study, twenty-one...

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11 Results Found

Novel Mutation in the Acetohydroxyacid Synthase (AHAS), Gene Confers Imidazolinone Resistance in Chickpea Cicer arietinum L. Plants

Cloning, Expression, Enzymatic Characterization and Mechanistic Studies of M13 Mutant Acetohydroxyacid Synthase That Rescues Valine Feedback Inhibition

Engineering Herbicide-Tolerance Rice Expressing an Acetohydroxyacid Synthase with a Single Amino Acid Deletion

Discovery of a New Class of Lipophilic Pyrimidine-Biphenyl Herbicides Using an Integrated Experimental-Computational Approach

Inheritance and Molecular Characterization of a Novel Mutated AHAS Gene Responsible for the Resistance of AHAS-Inhibiting Herbicides in Rapeseed (Brassica napus L.)

Total Synthesis of the Antimycobacterial Natural Product Chlorflavonin and Analogs via a Late-Stage Ruthenium(II)-Catalyzed ortho-C(sp2)-H-Hydroxylation

Pro197Thr Substitution in Ahas Gene Causing Resistance to Pyroxsulam Herbicide in Rigid Ryegrass (Lolium Rigidum Gaud.)

Detection of Target-Site Herbicide Resistance in the Common Ragweed: Nucleotide Polymorphism Genotyping by Targeted Amplicon Sequencing

Asymmetric Synthesis of Trifluoroethyl-Based, Chiral 3-Benzyloxy-1- and -2-Phenyl-quinazolinones of Biomedicinal Interest by Radical Type Cross-Coupling to Olefins

Exploring the Potential of Genista ulicina Phytochemicals as Natural Biocontrol Agents: A Comparative In Vitro and In Silico Analysis

Novel Sulfonylurea Derivatives as Potential Antimicrobial Agents: Chemical Synthesis, Biological Evaluation, and Computational Study

Total Synthesis of the Antimycobacterial Natural Product Chlorflavonin and Analogs via a Late-Stage Ruthenium(II)-Catalyzed ortho-C(sp²)-H-Hydroxylation