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16 Results Found

  • Article
  • Open Access

Long-Term Outcomes in Hemodialysis Patients According to Combined NT-proBNP and Galectin-3 Biomarker Profiles

  • Anca Elena Stefan,
  • Adrian Covic,
  • Maria Alexandra Covic,
  • Gianina Dodi,
  • Mugurel Apetrii,
  • Mihai Onofriescu,
  • Simona Hogas,
  • Stefan Iliescu and
  • Luminita Voroneanu
J. Clin. Med.2026, 15(3), 1129;https://doi.org/10.3390/jcm15031129 
(registering DOI)

1 February 2026

Background and Hypothesis: Mortality in hemodialysis (HD) remains high and is not fully explained by traditional risk factors. Biomarkers reflecting myocardial stress and fibrosis, together with measures of vascular stiffness, may provide additional...

  • Article
  • Open Access
8 Citations
3,803 Views
14 Pages

12 February 2019

N-terminal pro b-type natriuretic peptide (NT-proBNP) was considered a prognostic factor for mortality in hemodialysis patients in previous studies. However, NT-proBNP has not been fully explored in terms of predicting other clinical outcomes in hemo...

  • Article
  • Open Access
1 Citations
599 Views
14 Pages

CCN2/CTGF-Driven Myocardial Fibrosis and NT-proBNP Synergy as Predictors of Mortality in Maintenance Hemodialysis

  • Wen-Chin Ko,
  • Che-Shao Chen,
  • Yi-Ping Chang,
  • Chi-Sheng Wu,
  • Hung-Chi Yang and
  • Jia-Feng Chang

24 November 2025

Chronic inter-dialytic volume overload and uremic inflammation activate TGF-β/Smad3 and p38 MAPK pathways, inducing connective tissue growth factors (CCN2/CTGF)-mediated fibrosis and NT-proBNP secretion from over-stretched cardiomyocytes. The co...

  • Article
  • Open Access
1 Citations
1,554 Views
12 Pages

Association Between Malnutrition, Low Muscle Mass, Elevated NT-ProBNP Levels, and Mortality in Hemodialysis Patients

  • Sadamu Takahashi,
  • Tatsuki Tanaka,
  • Yusuke Suzuki,
  • Norihito Yoshida,
  • Mai Hitaka,
  • Shingo Ishii,
  • Keisuke Yamazaki,
  • Motoyuki Masai,
  • Yosuke Yamada and
  • Yasushi Ohashi

31 May 2025

Background/Objectives: Malnutrition, muscle wasting, and fluid overload are highly prevalent in patients undergoing maintenance hemodialysis (HD) and may contribute to increased mortality risk. However, the combined impact of these factors has not be...

  • Article
  • Open Access
5 Citations
2,560 Views
11 Pages

Prediction of Heart Function and Volume Status in End-Stage Kidney Disease Patients through N-Terminal Pro-Brain Natriuretic Peptide

  • Kyung Ho Lee,
  • Inki Moon,
  • Young Seung Oh,
  • Byung Chul Yu,
  • Moo Yong Park,
  • Jin Kuk Kim and
  • Soo Jeong Choi

22 July 2022

Background and Objectives: N-terminal pro-brain natriuretic peptide (NT-proBNP) is a biomarker used to predict heart failure and evaluate volume status in hemodialysis (HD) patients. However, it is difficult to determine the cutoff value for NT-proBN...

  • Article
  • Open Access
6 Citations
4,975 Views
14 Pages

16 December 2018

It is unclear whether N-terminal pro-brain type natriuretic peptide (NT-proBNP) level can be a biomarker for technique failure among long-term peritoneal dialysis (PD) patients. We prospectively included end-stage renal disease patients undergoing PD...

  • Article
  • Open Access
1 Citations
2,225 Views
10 Pages

The Association between Echocardiographic Parameters of Heart Failure with Preserved Ejection Fraction and Fluid Status Biomarkers in Hemodialysis Patients

  • Mariusz Lupa,
  • Agnieszka Pardała,
  • Anna Bednarek,
  • Jolanta Mrochem-Kwarciak,
  • Regina Deja,
  • Katarzyna Mizia-Stec and
  • Aureliusz Kolonko

Overhydration and cardiac function abnormalities are common in hemodialysis patients. The association of N-terminal prohormone for brain natriuretic peptide (NT-proBNP) and other fluid status biomarkers with echocardiographic parameters of heart fail...

  • Article
  • Open Access
2 Citations
2,567 Views
11 Pages

28 November 2023

Natriuretic peptides may be associated with the complex interaction between malnutrition and fluid overload. This study assessed the relationship between N-terminal pro-B-type natriuretic peptide (NT-proBNP), body fluid composition, and quality of li...

  • Article
  • Open Access
1 Citations
842 Views
27 Pages

The Burden of Heart Failure in End-Stage Renal Disease: Insights from a Retrospective Cohort of Hemodialysis Patients

  • Ioana Adela Ratiu,
  • Victor Vlad Babes,
  • Ozana Hocopan,
  • Cristian Adrian Ratiu,
  • Camelia Anca Croitoru,
  • Corina Moisa,
  • Ioana Paula Blaj-Tunduc,
  • Ana Marina Marian and
  • Elena Emilia Babeș

2 December 2025

Background: Heart failure (HF) is highly prevalent among patients on maintenance hemodialysis (HD) and contributes substantially to morbidity and mortality. This study aimed to evaluate the prevalence, clinical characteristics, and prognostic impact...

  • Article
  • Open Access
6 Citations
3,431 Views
11 Pages

Investigation of the Relationship between Cardiovascular Biomarkers and Brachial–Ankle Pulse Wave Velocity in Hemodialysis Patients

  • Ping-Ruey Chou,
  • Pei-Yu Wu,
  • Ping-Hsun Wu,
  • Teng-Hui Huang,
  • Jiun-Chi Huang,
  • Szu-Chia Chen,
  • Su-Chu Lee,
  • Mei-Chuan Kuo,
  • Yi-Wen Chiu and
  • Shang-Jyh Hwang
  • + 2 authors

15 April 2022

Brachial–ankle pulse wave velocity (baPWV) and cardiovascular (CV) biomarkers are correlated with clinical cardiovascular diseases (CVDs) in patients with kidney disease. However, limited studies evaluated the relationship between baPWV and CV biomar...

  • Article
  • Open Access
5 Citations
3,931 Views
12 Pages

Association between Intra- and Extra-Cellular Water Ratio Imbalance and Natriuretic Peptides in Patients Undergoing Hemodialysis

  • Yui Nakayama,
  • Yosuke Yamada,
  • Shingo Ishii,
  • Mai Hitaka,
  • Keisuke Yamazaki,
  • Motoyuki Masai,
  • Nobuhiko Joki,
  • Ken Sakai and
  • Yasushi Ohashi

3 March 2023

Natriuretic peptides are associated with malnutrition and volume overload. Over-hydration cannot simply be explained by excess extracellular water in patients undergoing hemodialysis. We assessed the relationship between the extracellular and intrace...

  • Article
  • Open Access
5 Citations
2,034 Views
11 Pages

9 October 2023

Recently, proenkephalin A (PENK A) has been shown to reflect glomerular dysfunction and to predict new-onset acute kidney injury and heart failure. While previous studies have investigated PENK A as a biomarker in individuals with preserved renal fun...

  • Article
  • Open Access
3 Citations
2,772 Views
13 Pages

Multi-Method Complex Approach for Hydration Assessment Does Not Detect a Hydration Difference in Hemodialysis versus Peritoneal Dialysis Patient

  • Anna Adamska-Wełnicka,
  • Marcin Wełnicki,
  • Paweł Krzesiński,
  • Stanisław Niemczyk and
  • Arkadiusz Lubas

29 September 2020

Assessment of hydration status is essential in monitoring the effectiveness of renal replacement therapy and is usually based on physical examination. However, comparisons of hydration status achieved with different dialysis methods are not conclusiv...

  • Article
  • Open Access
13 Citations
3,682 Views
14 Pages

Pre-Dialysis B-Line Quantification at Lung Ultrasound Is a Useful Method for Evaluating the Dry Weight and Predicting the Risk of Intradialytic Hypotension

  • Marco Allinovi,
  • Giulia Palazzini,
  • Gianmarco Lugli,
  • Iacopo Gianassi,
  • Lorenzo Dallari,
  • Selene Laudicina,
  • Marco Gregori,
  • Francesco Rossi,
  • Daniele Giannerini and
  • Calogero Lino Cirami
  • + 3 authors

29 November 2022

Intradialytic hypotension (IDH) is a frequent and well-known complication of hemodialysis, occurring in about one third of patients. An integrated approach with different methods is needed to minimize IDH episodes and their complications. In this pro...

  • Article
  • Open Access
891 Views
15 Pages

Clinical Significance of Phase Angle for Assessing Quality of Life and Prognosis in Hemodialysis Patients

  • Norihito Yoshida,
  • Tatsuki Tanaka,
  • Yusuke Suzuki,
  • Sadamu Takahashi,
  • Mai Hitaka,
  • Shingo Ishii,
  • Keisuke Yamazaki and
  • Yasushi Ohashi

21 November 2025

Background/Objectives: The phase angle (PA), derived from bioelectrical impedance analysis (BIA), reflects cellular integrity and nutritional status. Previous studies have reported associations between PA, QOL, and prognosis in hemodialysis patients;...

  • Article
  • Open Access
8 Citations
3,708 Views
19 Pages

Right Heart Changes Impact on Clinical Phenotype of Amyloid Cardiac Involvement: A Single Centre Study

  • Sebastiano Cicco,
  • Antonio Giovanni Solimando,
  • Roberta Buono,
  • Nicola Susca,
  • Gianfranco Inglese,
  • Assunta Melaccio,
  • Marcella Prete,
  • Roberto Ria,
  • Vito Racanelli and
  • Angelo Vacca

18 October 2020

Amyloidosis is due to deposition of an excessive amount of protein in many parenchymal tissues, including myocardium. The onset of cardiac Amyloidosis (CA) is an inauspicious prognostic factor, which can lead to sudden death. We retrospectively analy...