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  • Article
  • Open Access
8 Citations
3,296 Views
19 Pages

Molecular Characterization of the Interplay between Fasciola hepatica Juveniles and Laminin as a Mechanism to Adhere to and Break through the Host Intestinal Wall

  • Judit Serrat,
  • María Torres-Valle,
  • Marta López-García,
  • David Becerro-Recio,
  • Mar Siles-Lucas and
  • Javier González-Miguel

Fasciola hepatica is the main causative agent of fasciolosis, a zoonotic parasitic disease of growing public health concern. F. hepatica metacercariae are ingested by the host and excyst in the intestine, thereby releasing the newly excysted juvenile...

(This article belongs to the Special Issue Parasite Biology and Host-Parasite Interactions)
  • Article
  • Open Access
13 Citations
5,399 Views
16 Pages

8 December 2021

Fasciolosis caused by Fasciola hepatica is a major global disease of livestock and an important neglected helminthiasis of humans. Infection arises when encysted metacercariae are ingested by the mammalian host. Within the intestine, the parasite exc...

(This article belongs to the Special Issue Host-Parasite Relationships in Veterinary Parasitology: Get to Know Your Enemy before Fighting it)
  • Article
  • Open Access
6 Citations
3,955 Views
15 Pages

Modified Hederagenin Derivatives Demonstrate Ex Vivo Anthelmintic Activity against Fasciola hepatica

  • Anand Chakroborty,
  • Deiniol R. Pritchard,
  • Marc E. Bouillon,
  • Anna Cervi,
  • Rolf Kraehenbuehl,
  • Charlotte Wild,
  • Caroline Fenn,
  • Peter Holdsworth,
  • Colin Capner and
  • Karl F. Hoffmann
  • + 7 authors

Infection with Fasciola hepatica (liver fluke) causes fasciolosis (or fascioliasis) and poses a considerable economic as well as welfare burden to both the agricultural and animal health sectors. Here, we explore the ex vivo anthelmintic potential of...

(This article belongs to the Special Issue Development of Novel Pharmaceuticals for the Treatment of Parasitic Diseases)
  • Article
  • Open Access
31 Citations
4,459 Views
20 Pages

30 September 2022

The antioxidant superoxide dismutase (SOD) catalyses the dismutation of superoxide, a dangerous oxygen free radical, into hydrogen peroxide and molecular oxygen. Superoxide generation during the oxidative burst of the innate immune system is consider...

(This article belongs to the Special Issue Oxidative Stress in Parasites)
  • Article
  • Open Access
12 Citations
4,176 Views
13 Pages

Fasciolosis is a zoonotic disease caused by Fasciola gigantica or F. hepatica infections, which are frequently occurring parasites in animals and humans. The present gold-standard diagnostic technique involves finding parasite eggs through microscopy...

(This article belongs to the Special Issue Neglected Tropical Diseases (NTDs): Early Detection and Treatment towards Rational Control)
  • Communication
  • Open Access
4 Citations
3,116 Views
11 Pages

Antigens from the Helminth Fasciola hepatica Exert Antiviral Effects against SARS-CoV-2 In Vitro

  • Judit Serrat,
  • Clara Francés-Gómez,
  • David Becerro-Recio,
  • Javier González-Miguel,
  • Ron Geller and
  • Mar Siles-Lucas

SARS-CoV-2, the causal agent of COVID-19, is a new coronavirus that has rapidly spread worldwide and significantly impacted human health by causing a severe acute respiratory syndrome boosted by a pulmonary hyperinflammatory response. Previous data f...

(This article belongs to the Section Molecular Pharmacology)