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Viruses publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Hepatitis E: Molecular Virology, Pathogenesis, and Treatment, 3rd Edition

edited by

Hiroaki Okamoto

submission deadline 31 May 2026 | Viewed by 112 | Submission Open

Keywords: HEV; HEV life cycle; HEV genotypes; model systems; zoonosis; pathogenesis; HEV– host interactions; antivirals

(This special issue belongs to the Section Human Virology and Viral Diseases)

EBV Infection and EBV-Associated Lymphomas in Children

edited by Paola A. Chabay

submission deadline 31 May 2026 | Viewed by 105 | Submission Open

Keywords: EBV infection; Epstein– Barr virus (EBV); latent infection; malignancies; infectious mononucleosis; children; pathogenesis; primary infection

(This special issue belongs to the Section Human Virology and Viral Diseases)

Phage and Quorum Sensing

edited by

Emmanouil Flemetakis

and

Dimitrios Skliros

submission deadline 31 May 2026 | Viewed by 92 | Submission Open

Keywords: quorum sensing; quorum quenching; phage– bacteria interaction; auto-induced peptides; phage therapy

(This special issue belongs to the Section Bacterial Viruses)

CRISPR/Cas-Mediated Genome Editing in Viral Research

edited by

Kit San Yuen

submission deadline 31 May 2026 | Viewed by 69 | Submission Open

Keywords: CRISPR– Cas systems; viral genome engineering; antiviral gene therapy; host factor discovery (proviral and antiviral); CRISPR-based diagnostics

(This special issue belongs to the Section General Virology)

Flow Virometry: A New Tool for Studying Viruses: 2nd Edition

edited by John Yin

submission deadline 31 May 2026 | Viewed by 61 | Submission Open

Keywords: flow virometry; virus particle detection; virus counting; virus labeling/staining; virus-like particles; scanning ion occlusion sensing

(This special issue belongs to the Section General Virology)

Oropouche Virus (OROV): An Emerging Peribunyavirus (Bunyavirus)

edited by

David A. Schwartz

and

André Ricardo Ribas Freitas

submission deadline 1 Jun 2026 | 9 articles | Viewed by 28617 | Submission Open

Keywords: oropouche fever; oropouche virus; bunyavirus; epidemic; travel infection; pregnancy complications; stillbirth; microcephaly; brazil; Latin America; emerging virus

(This special issue belongs to the Section Human Virology and Viral Diseases)

Humoral Immune Response to Viruses

edited by Haiyan Zhao

submission deadline 6 Jun 2026 | 2 articles | Viewed by 2566 | Submission Open

Keywords: broadly neutralizing antibodies; protective antibodies; non-protective antibodies; epitopes; epitope-based vaccine design; B cell development; B cell repertoire; immune memory; vaccine development; plasma cells; antibody-based therapies

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Discovery, Classification, and Early Research on the Lipid-Containing, Double-Stranded RNA Bacteriophage φ6

edited by

Paul Gottlieb

and Aleksandra Alimova

submission deadline 15 Jun 2026 | 8 articles | Viewed by 26044 | Submission Open

Keywords: procapsid; nucleocapsid; polymerase complex; assembly; replication; recombination; packaging10

(This special issue belongs to the Section Bacterial Viruses)

Emerging and Re-Emerging Neuroinvasive Arboviruses

edited by

Rafael Freitas de Oliveira França

Rodrigo Stabeli

and Mylena R. Pereira

submission deadline 16 Jun 2026 | 1 articles | Viewed by 1092 | Submission Open

Keywords: arbovirus; innate immune response; adaptive immune response; epidemiology; diagnosis; prevention; vaccine; animal model; pathogenesis; viral evolution; in vitro; in vivo

(This special issue belongs to the Section Animal Viruses)

Surveillance, Prevention, and Treatment of Avian Influenza

edited by

Huihui Kong

and

Feng Wen

submission deadline 18 Jun 2026 | Viewed by 103 | Submission Open

Keywords: influenza; surveillance; molecular epidemiology; antigenic evolution; cross-species transmission; vaccine; antiviral therapy

(This special issue belongs to the Section Animal Viruses)

Zoonotic Viral Diseases: Drivers, Causes, Prevention and Cure, 2nd Edition

edited by

Claude Saegerman

submission deadline 30 Jun 2026 | 4 articles | Viewed by 7961 | Submission Open

Keywords: zoonotic viral diseases; drivers of emergence; disease mechanism and pathogenesis in reservoir host and end host; prevention mitigation measures; treatment

(This special issue belongs to the Section Animal Viruses)

An Update on Enterovirus Research, 2nd Edition

edited by

Benjamin M. Liu

submission deadline 30 Jun 2026 | 5 articles | Viewed by 6290 | Submission Open

Keywords: antivirals; enteroviruses; picornavirus; diagnostics; emerging and re-emerging diseases; viral proteins; virus replication; viral targets; virus– host interactions; vaccine development

(This special issue belongs to the Section Human Virology and Viral Diseases)

Viral Hemorrhagic Disease

edited by Joseph W. Golden and Aura R. Garrison

submission deadline 30 Jun 2026 | 3 articles | Viewed by 5318 | Submission Open

Keywords: host factors contributing to severe disease; immune correlates of protection; animal models; persistent infections; surveillance of hemorrhagic fever viruses; prophylactic and therapeutic development against hemorrhagic fever viruses

(This special issue belongs to the Section Animal Viruses)

Advances in Research on HIV Drug Resistance and Other Determinants of Treatment Success: 3rd Edition

edited by

Alberto Borghetti

submission deadline 30 Jun 2026 | 3 articles | Viewed by 5174 | Submission Open

Keywords: HIV; antiretroviral therapies; virological failure; HIV drug resistance; HIV reservoir; HIV viral subtype; predictors of virological failure

(This special issue belongs to the Section Human Virology and Viral Diseases)

Immune Responses to Papillomavirus Infections: 2nd Edition

edited by

Jiafen Hu

submission deadline 30 Jun 2026 | 2 articles | Viewed by 4108 | Submission Open

Keywords: papillomavirus; HPV; immune responses; infections; models

(This special issue belongs to the Section Human Virology and Viral Diseases)

Advances in Understanding Viral Pathogenesis and Host Immune Responses to Arboviruses and Respiratory Viruses

edited by

Laura Beatriz Talarico

and

Claudia Filomatori

submission deadline 30 Jun 2026 | 3 articles | Viewed by 3720 | Submission Open

Keywords: arboviruses; respiratory viruses; viral pathogenesis; host immune responses; innate immunity; adaptive immunity; viral immune evasion; cytokine storm; interferon response; viral replication; viral transmission; immunopathology; neutralizing antibodies; host– virus interactions

(This special issue belongs to the Section Animal Viruses)

Influenza Viruses in Wildlife 2026

edited by

Rebecca Poulson

and Wendy Blay Puryear

submission deadline 30 Jun 2026 | 3 articles | Viewed by 2894 | Submission Open

Keywords: avian influenza; wild birds; wildlife; influenza epidemiology; surveillance; HPAI

(This special issue belongs to the Section Animal Viruses)

Navigating Viral Threats: Enteric and Respiratory Viral Challenges in the Post-COVID-19 Era

edited by Ahmed Mostafa and Abdou Allayeh

submission deadline 30 Jun 2026 | 1 articles | Viewed by 1100 | Submission Open

Keywords: enteric viruses; respiratory viruses; human influenza viruses; COVID-19; avian influenza viruses; surveillance; virus epidemiology; viral diagnosis

(This special issue belongs to the Section Human Virology and Viral Diseases)

ASFV Countermeasures, Pathogenesis, and Epidemiology

edited by Douglas P. Gladue

submission deadline 30 Jun 2026 | 1 articles | Viewed by 676 | Submission Open

Keywords: ASF; african swine fever; swine; countermeasures; therapeutics; pathogenesis and epidemiology

(This special issue belongs to the Section Animal Viruses)

Advances in Honey Bee Viruses Research

edited by

Benjamin J. Lamp

and Kerstin Seitz

submission deadline 30 Jun 2026 | Viewed by 570 | Submission Open

Keywords: honey bee viruses; deformed wing virus; DWV; sacbrood virus; SBV; chronic bee paralysis virus; CBPV; acute bee paralysis virus; ABPV; Israel acute bee paralysis virus; IAPV; Iflavirus; Dicistrovirus; rhabdovirus; ARV

(This special issue belongs to the Section Invertebrate Viruses)

Viral Infection and Platelets’ Disorders

edited by

Pierpaolo Di Micco

Alessandro Perrella

and

Giuseppe Camporese

submission deadline 30 Jun 2026 | Viewed by 479 | Submission Open

Keywords: viral infections; thrombosis; thrombotic microangiopathies; disseminated intravascular coagulation; low molecular weight heparin; bleedings; acute infections

(This special issue belongs to the Section Human Virology and Viral Diseases)

RNA Viruses Replication and Innate Immunity

edited by

Griffith Parks

submission deadline 30 Jun 2026 | Viewed by 442 | Submission Open

Keywords: RNA virus replication and transcription; pathogen-associated molecular patterns; interferons; cytokines; signaling pathways

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Advances in Parapoxvirus Research: From Veterinary Infections to Public Health Implications

edited by

Yoon-Seok Chung

submission deadline 30 Jun 2026 | Viewed by 245 | Submission Open

Keywords: parapoxviruses; zoonotic implications; diagnostic innovation; veterinary infections; molecular epidemiology; genomic surveillance

(This special issue belongs to the Section Animal Viruses)

Porcine Virus–Host Interactions: Entry, Tropism, Immune Evasion and Control

edited by

Levon Abrahamyan

submission deadline 30 Jun 2026 | Viewed by 106 | Submission Open

Keywords: porcine viruses; virus– host interactions; viral entry; tropism; immune evasion; viral escape; antivirals; single-cell/spatial omics; cell imaging; virus trafficking

(This special issue belongs to the Section Animal Viruses)

Virus Infection and Extracellular Vesicles

edited by

Matthias A. Clauss

submission deadline 30 Jun 2026 | Viewed by 94 | Submission Open

Keywords: extracellular vesicles; exosomes; virus; viral infection; inflammation; immune function; comorbidities

(This special issue belongs to the Section General Virology)

HIV Infection, Latency, Pathogenesis and Associated Comorbidities, Including Cancer and Inflammation in the Context of Drugs of Abuse and ART

edited by

Mudit Tyagi

submission deadline 30 Jun 2026 | Viewed by 78 | Submission Open

Keywords: HIV infection; HIV transcription and latency; HIV; ART and drugs of abuse associated comorbidities in people living with HIV (PLWH); HIV; ART and drugs of abuse associated cancer; HIV; ART and drugs of abuse associated inflammation and aging

(This special issue belongs to the Section Human Virology and Viral Diseases)

Viral Neuropathogenesis: Mechanisms, Models, and Therapeutic Strategies

edited by

Mukesh Kumar

submission deadline 30 Jun 2026 | Viewed by 71 | Submission Open

Keywords: neurotropic viruses; neuroinflammation; blood– brain barrier; CNS viral infection models; host– pathogen interactions; antiviral immunity; neurological complications; neurodegeneration; viral encephalitis

Bacteriophage-Based Biocontrol in Agriculture, 3rd Edition

edited by

Elena G. Biosca

and

María Belén Álvarez Ortega

submission deadline 30 Jun 2026 | Viewed by 58 | Submission Open

Keywords: phage-therapy; biocontrol; phytopathogenic bacteria; bioproduction; field application

(This special issue belongs to the Section Bacterial Viruses)

Avian Reovirus 2026

edited by

Sunil Mor

and

Krisztián Bányai

submission deadline 30 Jun 2026 | Viewed by 31 | Submission Open

Keywords: avian reoviruses (ARVs); pathogenesis; genotyping; vaccines; poultry

(This special issue belongs to the Section Animal Viruses)

Bacteriophages as Precision Tools for Microbiome Modulation

edited by

Michał Wójcicki

Iwona Gientka

and

Paulina Średnicka

submission deadline 30 Jun 2026 | Viewed by 29 | Submission Open

Keywords: bacteriophages; microbiome; phageome; phagobiotics; gut microbiota; phage-host interactions; prophage induction; immunomodulation; dysbiosis; host immunity; phage therapy; bioinformatics; metagenomics; systems biology

(This special issue belongs to the Section Bacterial Viruses)

Advances in Viral Integration: Mechanisms, Targeting, Reservoirs and Therapeutics

edited by

Stephen Barr

submission deadline 30 Jun 2026 | Viewed by 16 | Submission Open

Keywords: viral integration; integration site selection; chromatin topology; anatomical reservoir; latent provirus; clonal expansion; insertional mutagenesis; gene therapy vector; integrase/co-factor; emerging virus integration

(This special issue belongs to the Section General Virology)

Plant Virus Research and Biotechnology-Based Resistance Strategies—In Honor of Professor Andrew Otis Jackson

edited by

Aiming Wang

Fangfang Li

and Jonathan Griffiths

submission deadline 7 Jul 2026 | Viewed by 91 | Submission Open

Keywords: viral pathogenicity; virus movement; viral replication; virus induced gene silencing; RNA silencing suppressor; molecular plant-virus interaction; host factor; antiviral defense response; virus-vector interaction and transmission; virus evolution

(This special issue belongs to the Section Viruses of Plants, Fungi and Protozoa)

High Consequence Viral Transmission

edited by

Olivier Escaffre

submission deadline 17 Jul 2026 | Viewed by 114 | Submission Open

Keywords: high-consequence viruses; zoonotic viruses; spillover events; natural reservoirs; wildlife vectors; pandemic; outbreaks; airborne transmission; droplet transmission; sexual transmission; high fatality rates; Filoviridae; Orthoebolavirus; Orthomarbugvirus; Paramyxoviridae; Orthoparamyxovirinae; Arenaviridae; Mammarenavirus; Peribunyaviridae; Orthobunyavirus; Nairoviridae; Orthonairovirus; Hantaviridae; Orthohantavirus; Coronaviridae; Betacoronavirus

(This special issue belongs to the Section Human Virology and Viral Diseases)

Rodent-Borne Viruses 2026

edited by

Renata Carvalho De Oliveira

and

Jorlan Fernandes

submission deadline 31 Jul 2026 | 3 articles | Viewed by 7794 | Submission Open

Keywords: rodent-borne viruses; hantaviridae; arenaviridae; poxviridae; zoonosis; virus ecology and evolution; virus– host interaction; virus discovery; animal model; rodents

(This special issue belongs to the Section Animal Viruses)

Molecular Epidemiology of SARS-CoV-2, 4th Edition

edited by

Marta Giovanetti

submission deadline 31 Jul 2026 | 4 articles | Viewed by 3669 | Submission Open

Keywords: SARS-CoV-2; genomic monitoring; phylodynamic; molecular epidemiology

(This special issue belongs to the Section Coronaviruses)

Interaction Between Influenza Virus and Host Cell

edited by

Flora De Conto

submission deadline 31 Jul 2026 | 1 articles | Viewed by 1879 | Submission Open

Keywords: influenza virus; virus-– host interaction; restriction factor; host species barrier; pandemic; pathogenicity; zoonosis; cell culture

(This special issue belongs to the Section Animal Viruses)

Vaccines and Antiviral Drugs Against Viral Diseases in Domestic Animals

edited by

Jing Zhang

submission deadline 31 Jul 2026 | 2 articles | Viewed by 1817 | Submission Open

Keywords: vaccines; antiviral drugs; domestic animals; virus

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

HIV in the Context of Chronic Disorders and Aging

edited by

Maria Mazzitelli

Andrea De Vito

and Mattia Trunfio

submission deadline 31 Jul 2026 | 1 articles | Viewed by 1538 | Submission Open

(This special issue belongs to the Section Human Virology and Viral Diseases)

Structural and Mechanistic Advances in Retroviral Biology

edited by Yong Xiong,

Swapnil Chandrakant Devarkar

and

Luiza Mendonca

submission deadline 31 Jul 2026 | 1 articles | Viewed by 840 | Submission Open

Keywords: retroviruses; capsid structure and assembly; host-viral interactions; in situ cryo EM; reverse transcription; integration; genome packaging

(This special issue belongs to the Section Human Virology and Viral Diseases)

Giant, Jumbo and Mega Phages

edited by

Julie Thomas

submission deadline 31 Jul 2026 | Viewed by 655 | Submission Open

Keywords: long-genome phage; giant phage; jumbo phage; mega phage; genomes; structure/assembly; infection strategies; ecology; evolution; applications

(This special issue belongs to the Section Bacterial Viruses)

Virus-Host Interactions: From Mechanisms to Therapeutics

edited by

Leike Zhang

and

Ke Xu

submission deadline 31 Jul 2026 | Viewed by 619 | Submission Open

Keywords: host-directed antivirals; antiviral agents; drug resistance; host factors; viral– host interplay

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Human Adenovirus (HAdV) Infection in Children

edited by Adriana Kajon and

Glen R. Nemerow

submission deadline 31 Jul 2026 | Viewed by 501 | Submission Open

Keywords: epidemiology; pediatric; transplant recipients; antivirals; outbreak; acute respiratory illness; gastroenteritis

(This special issue belongs to the Section Human Virology and Viral Diseases)

Viroinformatics and Viral Diseases

edited by

Hernan Garcia-Ruiz

submission deadline 31 Jul 2026 | Viewed by 169 | Submission Open

Keywords: viral genomics; virus variation; genome-wide variation; gene silencing; antiviral defense; virus replication; host factors; high-throughput sequencing; small RNA sequencing

(This special issue belongs to the Section General Virology)

Phage: Biocontrol and Biosafety

edited by Ran Wang and Tao He

submission deadline 31 Jul 2026 | Viewed by 159 | Submission Open

Keywords: phage– host interaction; biocontrol and biosafety; antimicrobial resistance; pharmacokinetics/pharmacodynamics of phage; phage and immunity; phage safety assessment; regulatory frameworks

(This special issue belongs to the Section Bacterial Viruses)

Phage Evolution: Taxonomy, Origins, and Diversity

edited by

Peter Evseev

and

Dann Turner

submission deadline 31 Jul 2026 | Viewed by 148 | Submission Open

Keywords: phage taxonomy and phylogeny; origins and evolution of phage genes and genomes; phage-host coevolution; phage diversity and ecology; artificial evolution of phages; computational and bioinformatic approaches to phage evolution

(This special issue belongs to the Section Bacterial Viruses)

Viral Aerosol Transmission, Host Environmental Exposures, and Antiviral Intervention Strategies

edited by

St Patrick Reid

submission deadline 31 Jul 2026 | Viewed by 145 | Submission Open

Keywords: viral aerosol transmission; host– environment interactions; emerging cellular mechanisms; antiviral therapeutics; immune defense mechanisms

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Oncolytic Virus Engineering for Tumor Immunotherapy

edited by

Stefan Weger

submission deadline 31 Jul 2026 | Viewed by 114 | Submission Open

Keywords: oncolytic viruses (OV); cancer immunotherapy; cancer treatment; genetic engineering; tumor-specificity; tumor-specific promoters; immunosuppressive; tumor micro environment (TME)

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Viral Immune Imprinting and Vaccine Design

edited by