EBV Infection and EBV-Associated Lymphomas in Children
A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Human Virology and Viral Diseases".
Deadline for manuscript submissions: 31 May 2026 | Viewed by 30
Special Issue Editor
Interests: EBV-positive DLBCL lymphomas; plasmablastic lymphomas
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Epstein–Barr virus (EBV) displays unique behavior. In most people, EBV establishes a life-long latent infection, presumably as a harmless passenger, in a delicate equilibrium with the host’s immune system. However, given its ability to express a broad repertoire of latent and lytic antigens with oncogenic potential, EBV has been implicated in the development of malignancies in susceptible individuals. There is a complex interplay between age of acquisition, symptomatic versus asymptomatic infection, and the subsequent risk of EBV-associated cancers. When primary infection occurs in adolescents and young adults, they are more likely to experience infectious mononucleosis. However, EBV infection in children is predominantly asymptomatic, and the means of transmission in young children remains unknown. In developed populations, infectious mononucleosis in young adults increases the risk of Hodgkin’s lymphoma, whereas this scenario in children is yet to be elucidated.
In this Special Issue, we aim to address the pathogenesis of various EBV-associated pediatric tumors, as well as primary and persistent EBV infection in children, with the goal of elucidating the relationship between age at primary infection and the subsequent development of EBV-related malignancies in pediatric populations.
Dr. Paola A. Chabay
Guest Editor
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Keywords
- EBV infection
- Epstein–Barr virus (EBV)
- latent infection
- malignancies
- infectious mononucleosis
- children
- pathogenesis
- primary infection
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