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Viruses publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Herpesviruses and Associated Diseases, 2nd Edition

edited by

Sherif T.S. Hassan

submission deadline 20 Mar 2026 | Viewed by 111 | Submission Open

Keywords: human herpesviruses; animal herpesviruses; viral latency and reactivation; immune evasion strategies; herpesvirus– host interactions; herpesvirus biology and pathogenesis; herpesvirus diagnosis; environmental factors; herpesvirus-associated diseases; prevention and treatment strategies; antiviral therapies; vaccine development

(This special issue belongs to the Section Human Virology and Viral Diseases)

Viral Diseases of Sheep and Goats

edited by Ramsés Reina and Álex Gómez

submission deadline 30 Mar 2026 | 4 articles | Viewed by 5397 | Submission Open

Keywords: small ruminants; viral immunopathogenesis; infection; transmission; epidemiology; control strategies; vaccines

(This special issue belongs to the Section Animal Viruses)

Coronaviruses and Influenza Viruses: Evolution, Cross-Species Transmission, and Recombination

edited by

Maged Gomaa Hemida

submission deadline 31 Mar 2026 | 5 articles | Viewed by 11141 | Submission Open

Keywords: coronaviruses; influenza viruses; highly pathogenic influenza viruses; species jump; avian coronaviruses; porcine coronaviruses; vaccines; diagnostic assays; one health; virus/host interaction.

(This special issue belongs to the Section Coronaviruses)

Host-Mediated Viral Mutations: APOBECs, ADARs, and Beyond

edited by

Jaquelin P. Dudley

submission deadline 31 Mar 2026 | 4 articles | Viewed by 7340 | Submission Open

Keywords: cytosine and adenosine deamination; methylcytosine; epigenetics; mutagenesis; cancer; APOBEC antagonists; ADAR; DNA damage response; innate immunity; adaptive immunity; virus selection

(This special issue belongs to the Section Human Virology and Viral Diseases)

Hepatitis Viral Infections, Pathogenesis and Therapeutics (2nd Edition)

edited by

Fan Zhu

submission deadline 31 Mar 2026 | 3 articles | Viewed by 6842 | Submission Open

Keywords: hepatitis A virus (HAV); hepatitis B virus (HBV); hepatitis C virus (HCV); hepatitis D virus (HDV); hepatitis E virus (HEV); chronic liver disease; chronic hepatitis; liver cirrhosis; hepatocellular carcinoma (HCC); liver cancer; antiviral therapy

(This special issue belongs to the Section Human Virology and Viral Diseases)

Cascade of Care for HIV, Hepatitis and Sexually Transmitted Infections

edited by

Justyna Dominika Kowalska

submission deadline 31 Mar 2026 | 6 articles | Viewed by 6350 | Submission Open

Keywords: HIV; AIDS; cascade; linkage; HCV; HBV; sexually transmitted infections

(This special issue belongs to the Section Human Virology and Viral Diseases)

Interferon Signaling in Viral Pathogenesis

edited by Lishan Su

submission deadline 31 Mar 2026 | 4 articles | Viewed by 6286 | Submission Open

Keywords: type I interferons; virus replication; viral pathogenesis; autoimmune diseases; inflamation-induced cancer; immunotherapy

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Animal Herpesvirus 2025

edited by

Shafiqul Chowdhury

submission deadline 31 Mar 2026 | 4 articles | Viewed by 4754 | Submission Open

Keywords: herpesviruses; innate immune responses; host adaptive immune responses; herpesvirus-host; interactions; susceptibility

(This special issue belongs to the Section Animal Viruses)

Herpesvirus Transcriptional Control

edited by

David Davido

submission deadline 31 Mar 2026 | 3 articles | Viewed by 3823 | Submission Open

Keywords: herpes simplex virus; herpesvirus gene expression; viral latency and reactivation; virus– host interactions

(This special issue belongs to the Section Animal Viruses)

Porcine Epidemic Diarrhea Virus (PEDV): A Persistent Threat to the Global Swine Industry

edited by

Ke Liu

submission deadline 31 Mar 2026 | 3 articles | Viewed by 3058 | Submission Open

Keywords: porcine epidemic diarrhea virus; global epidemiology; economic loss; vaccines and drugs; molecular mechanism; transmission and pathogenic mechanisms

(This special issue belongs to the Section Animal Viruses)

HPV-Associated Cancers 2025

edited by Diane M. Harper

submission deadline 31 Mar 2026 | 1 articles | Viewed by 2992 | Submission Open

Keywords: HPV; cervical cancer; head and neck cancer; penile cancer; cancer prevention; targeted therapy; cancer stem cells; molecular study; carcinogenesis; immunotherapy

(This special issue belongs to the Section Human Virology and Viral Diseases)

Advancements in Immunotherapy for Human Papillomavirus

edited by Katharine A. Price

submission deadline 31 Mar 2026 | 1 articles | Viewed by 2826 | Submission Open

Keywords: human papillomavirus; cancer screening; vaccination; treatment; head-and-neck cancer; oropharyngeal cancer

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Tick-Borne Viruses 2026

edited by

Pat Nuttall

submission deadline 31 Mar 2026 | 3 articles | Viewed by 2742 | Submission Open

Keywords: tick-borne viruses; vector-borne pathogens; virus– tick– host interactions; saliva-assisted transmission; tick exosomes; tick antiviral mechanisms; virus evolution; surveillance

(This special issue belongs to the Section General Virology)

Development of Diagnostics and Therapeutic Interventions for Viral Infections of the Central Nervous System

edited by Karin E. Peterson and Amanda E. Calvert

submission deadline 31 Mar 2026 | 1 articles | Viewed by 2231 | Submission Open

Keywords: encephalitis; arbovirus; diagnosis; treatment; neurovirology; antibody therapeutics; agnostic therapeutics; point of care diagnostics; rapid diagnostics

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Advances in HSV

edited by Susmit Suvas and James Chodosh

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1944 | Submission Open

Keywords: HSV-1; HSV-2; latency; herpes epithelial keratitis; herpes stromal keratitis; HSV vaccine; herpes simplex encephalitis

(This special issue belongs to the Section Human Virology and Viral Diseases)

Regulation of HIV-1 Transcription and Latency, 2nd Edition

edited by

Uri Mbonye

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1665 | Submission Open

Keywords: HIV provirus; HIV latency; latency reversal; HIV transcription initiation; HIV transcription elongation; transcription factors; epigenetic silencing; posttranscriptional control of HIV gene expression; transcriptomic analysis of HIV infection; HIV reservoir

(This special issue belongs to the Section Human Virology and Viral Diseases)

Dengue, Zika and Yellow Fever Virus Replication

edited by

Rosa M. Del Angel

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1615 | Submission Open

Keywords: flavivirus; dengue; Zika; yellow fever; virus replication; virus entry; genome replication; host cell factors; replication structures

(This special issue belongs to the Section Invertebrate Viruses)

HIV and Viral Hepatitis Co-Infection

edited by

Sonia Moretti

and

Ivan Schietroma

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1376 | Submission Open

Keywords: HIV; hepatitis A; hepatitis B; hepatitis C; hepatitis delta; hepatitis E; co-infection; antiviral therapy

(This special issue belongs to the Section Human Virology and Viral Diseases)

Novel Insights into Porcine Viral Diseases: Recombinant Strains and Immune Responses

edited by

Kegong Tian

and

Xiangdong Li

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1368 | Submission Open

Keywords: porcine viral diseases; epidemiology; pathogenesis; recombination; immune responses

(This special issue belongs to the Section Animal Viruses)

Recent Advances in Anti-HCV, Anti-HBV and Anti-Flavivirus Agents, 2nd Edition

edited by

Grigoris Zoidis

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1352 | Submission Open

Keywords: medicinal chemistry of anti-HCV; anti-HBV and anti-flavivirus agents; synthesis; structure activity relationships (SAR); antiviral drug discovery; HBV; HCV; Dengue (DENV); Yellow Fever (YFV); West Nile (WNV); Zika (ZIKV); mechanism of action; drug targets; in silico studies

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

HIV and Aging

edited by Eugenia Negredo

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1113 | Submission Open

Keywords: HIV and aging; accelerated and accentuated aging; immune senescence; inflammation; comorbidities; geriatric syndromes; neurocognitive function; functional status; antiretroviral therapy

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Virus Bioinformatics 2025

edited by

Manja Marz

and

Maria Fabisch

submission deadline 31 Mar 2026 | Viewed by 951 | Submission Open

Keywords: virus bioinformatics; software; viral metagenomics and ecology; virus– host interactions; viral diversity and evolution; virus identification

(This special issue belongs to the Section General Virology)

Bacteriophages and Biofilms 2026

edited by

Bartłomiej Grygorcewicz

submission deadline 31 Mar 2026 | 1 articles | Viewed by 832 | Submission Open

Keywords: bacteriophages; phage therapy; biofilms; phage– biofilm interaction; depolymerases; antibiofilm agents; phage engineering; phage resistance; combination therapy; microbial ecology

(This special issue belongs to the Section Bacterial Viruses)

Epidemiology, Risk Analysis, Detection and Management of Lumpy Skin Disease in Europe

edited by

Claude Saegerman

submission deadline 31 Mar 2026 | 1 articles | Viewed by 831 | Submission Open

Keywords: lumpy skin disease (LSD); lumpy skin disease virus (LSDV); vectors; pathogenesis; epidemiology; modelling; risk analysis; detection; management; cost– benefit analysis; Europe

(This special issue belongs to the Section Animal Viruses)

Lytic Cycle of Herpesviruses and the Associated Pathogenesis

edited by Junjie Zhang,

Yonggang Pei

and Tingting Li

submission deadline 31 Mar 2026 | Viewed by 523 | Submission Open

Keywords: herpesviruses; innate immune responses; life cycle; herpesvirus– host interactions; pathogenesis

(This special issue belongs to the Section Human Virology and Viral Diseases)

New Findings in Animal Biosecurity Related to Viral Diseases

edited by

Claude Saegerman

and Jean-Pierre Vaillancourt

submission deadline 31 Mar 2026 | 1 articles | Viewed by 512 | Submission Open

Keywords: viruses; animal; biosecurity; evaluation; communication; needs; cost– benefit analysis; behaviour change

(This special issue belongs to the Section Animal Viruses)

Viral Non-Structural Proteins

edited by

Giuseppe Sautto

submission deadline 31 Mar 2026 | Viewed by 274 | Submission Open

Keywords: viral genome; non-structural proteins; virus replication; vaccines; viral therapeutics

(This special issue belongs to the Section General Virology)

Advances in Plant Virus/Viroid Detection and Identification Methods, 2nd Edition

edited by Laura Tomassoli and

Antonio Tiberini

submission deadline 31 Mar 2026 | Viewed by 274 | Submission Open

Keywords: plant viruses and viroids diagnostics; high-throughput sequencing; bioinformatics; virus taxonomy; virus/viroid– plant– vector interactions; real-time PCR; digital droplet PCR; hyperspectral imaging; machine learning; artificial intelligence; biosensors

(This special issue belongs to the Section Viruses of Plants, Fungi and Protozoa)

Chikungunya Virus in Viral Immunology and Vaccine Research

edited by Shuaiyao Lu and

Hongyu Chen

submission deadline 31 Mar 2026 | Viewed by 217 | Submission Open

Keywords: Chikungunya virus; viral immunology; CHIKV vaccine development; virus– host interactions; innate immunity; adaptive immunity; neutralizing antibodies; viral pathogenesis; vaccine platforms; antivirals; Alpha virus

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Rabies Virus: Treatment and Prevention—2nd Edition

edited by

Paulo Eduardo Brandão

submission deadline 31 Mar 2026 | Viewed by 170 | Submission Open

Keywords: rabies; antiviral; treatment; prevention

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Japanese Encephalitis Virus and Other Closely Related Clinically Important Orthoflaviviruses—a Persistent Threat to Public and Animal Health

edited by

Ke Liu

submission deadline 31 Mar 2026 | Viewed by 148 | Submission Open

Keywords: Japanese encephalitis virus; mosquito-borne; orthoflaviviruses; public and animal health; transmission; infection; host

(This special issue belongs to the Section General Virology)

Antiviral Protease Inhibitors

edited by Xufang Deng and

Jun Wang

submission deadline 31 Mar 2026 | Viewed by 115 | Submission Open

Keywords: antiviral drug discovery; high-throughput screen; structure-guided drug design; artificial intelligence (AI)-based drug discovery; drug resistance; combination therapies; antiviral assay development; host-targeting antiviral

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Immune Evasion and Viral Carcinogenesis

edited by

Christoph Weigel

and Tuan L. Phan

submission deadline 31 Mar 2026 | Viewed by 114 | Submission Open

Keywords: viral oncogenesis; viral carcinogenesis; immune evasion; immune surveillance; oncogenic viruses; immunosuppression; host-pathogen interactions

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

SARS-CoV-2 in Pregnancy and Reproduction, 2nd Edition

edited by

Justin C. Konje

submission deadline 31 Mar 2026 | Viewed by 106 | Submission Open

Keywords: COVID-19; SARS-CoV-2; coronavirus; pregnancy; reproduction; vaccination; mutagenesis

(This special issue belongs to the Section Coronaviruses)

Polyomavirus

edited by

Sunnie R. Thompson

and Patrick S. Moore

submission deadline 1 Apr 2026 | Viewed by 127 | Submission Open

Keywords: virus– host interactions; viral life cycle; viral replication; pathogenesis; phylogeny; structure; transcription; packaging; trafficking; persistence; re-arrangements; gene regulation; reactivation; miRNA; viral immune evasion; vaccines

(This special issue belongs to the Section Animal Viruses)

Human Leukocyte Antigen (HLA) in Viral Infections

edited by Nicholas Borcherding

submission deadline 5 Apr 2026 | Viewed by 405 | Submission Open

Keywords: HLA; viral infection; immune response; T cells; antigen presentation; viral evasion; immunogenetics; polymorphism; disease susceptibility; vaccine development

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Beyond Acute: Navigating Long COVID and Post-Viral Complications

edited by Maggie Bartlett, Janko Nikolich-Žugich, Rubeshan Perumal and Anders Vahlne

submission deadline 15 Apr 2026 | 4 articles | Viewed by 8930 | Submission Open

Keywords: long COVID; post-viral complications; dysregulated immune responses; neurological complications; respiratory complications; cardiovascular complications; pregnancy-related complications

(This special issue belongs to the Section Human Virology and Viral Diseases)

Broadly Protective Anti-Viral Vaccines 2025

edited by

Lei Deng

submission deadline 15 Apr 2026 | 1 articles | Viewed by 2522 | Submission Open

Keywords: universal vaccines; structure-based rational design; cross-protection; broadly neutralizing antibody; T-cell epitopes; preventative and therapeutic vaccines; adaptive immunology; highly variable virus

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Swine Viruses: Immunology and Vaccinology

edited by

Yue Wang

and

Hongying Chen

submission deadline 15 Apr 2026 | 1 articles | Viewed by 1603 | Submission Open

Keywords: swine virology; swine immunology; vaccine development; vaccinology; viral pathogenesis; vaccine design; disease prevention; swine health

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Cross-Pathogen Insights into Infectious Diseases: From Biomarkers to Burden and Therapeutic Strategies of Viral Pathogens

edited by

Karolina Akinosoglou

submission deadline 15 Apr 2026 | 1 articles | Viewed by 417 | Submission Open

Keywords: cross-pathogen perspective; biomarkers; viral sepsis; therapeutic landscape

(This special issue belongs to the Section General Virology)

Mechanisms of Ribozyviria Transmission in Animal and Vegetal Holobionts

edited by

Maurizia Rossana Brunetto

and Ferruccio Bonino

submission deadline 15 Apr 2026 | Viewed by 262 | Submission Open

Keywords: viroid-like RNAs; holobionts; RNA viruses; circular RNA genomes; satellite viruses; HBsAg (hepatitis b surface antigen)

(This special issue belongs to the Section General Virology)

Viral Infections in Hematopoietic Stem Cell Transplant and Cellular Therapy Recipients, 2nd Edition

edited by Sanjeet Singh Dadwal

submission deadline 15 Apr 2026 | Viewed by 169 | Submission Open

Keywords: HSCT; GVHD; HHV6; CMV; adenovirus; BK and JC virus (polyomaviruses); HIV

(This special issue belongs to the Section Human Virology and Viral Diseases)

HIV-1 Infection and Immunometabolism: Relevance to HIV Pathogenesis and Persistence 3.0

edited by

Sonia Moretti

submission deadline 20 Apr 2026 | 3 articles | Viewed by 7294 | Submission Open

Keywords: immunometabolism; HIV-1; inflammation; immune activation; HIV pathogenesis; HIV latency; innate/adaptive immunity; metabolic diseases; non-AIDS-associated comorbidities

(This special issue belongs to the Section Human Virology and Viral Diseases)

Molecular Epidemiology, Evolution, and Dispersion of Flaviviruses (2nd Edition)

edited by

Marta Giovanetti

Fernanda De Bruycker Nogueira

Ana Maria Bispo De Filippis

and

Anne Paiva

submission deadline 30 Apr 2026 | 5 articles | Viewed by 21483 | Submission Open

Keywords: flavivirus; evolution; genomic epidemiology; phylodynamics; transmission

(This special issue belongs to the Section Animal Viruses)

JC Polyomavirus

edited by

Sébastien Lhomme

and Anne-Sophie L'Honneur

submission deadline 30 Apr 2026 | 4 articles | Viewed by 10518 | Submission Open

Keywords: JC polyomavirus; progressive multifocal leukoencephalopathy (PML); neurotropic variants; viral genomic rearrangements

(This special issue belongs to the Section Human Virology and Viral Diseases)

Application of Plant Viruses in Biotechnology

edited by

Kathleen Hefferon

and

Srividhya Venkataraman

submission deadline 30 Apr 2026 | 3 articles | Viewed by 3886 | Submission Open

Keywords: plant viruses; viral nanoparticles; plant viral vectors; biotechnological applications

(This special issue belongs to the Section Viruses of Plants, Fungi and Protozoa)

Human Cytomegalovirus Therapeutic Strategies and Clinical Applications

edited by Ravit Arav-Boger

submission deadline 30 Apr 2026 | 3 articles | Viewed by 3742 | Submission Open

Keywords: human cytomegalovirus (HCMV); congenital infection; transplantation; side effects; resistance; therapeutic strategies; combination therapy

(This special issue belongs to the Section Human Virology and Viral Diseases)

Plant Viral Pathogens: Innovations in Detection, Genetic Diversity, and Evolutionary Dynamics

edited by

Akhtar Ali

submission deadline 30 Apr 2026 | 3 articles | Viewed by 3336 | Submission Open

Keywords: high-throughput sequencing; RT-PCR and qRT-PCR; genetic diversity; virus evolution; mutations; reassortment; recombination

(This special issue belongs to the Section Viruses of Plants, Fungi and Protozoa)

Human T-Cell Leukemia Virus (HTLV) Infection and Treatment: 2nd Edition

edited by Cynthia A. Pise-Masison and Damian F. J. Purcell

submission deadline 30 Apr 2026 | 2 articles | Viewed by 2644 | Submission Open

Keywords: HTLV; HTLV-associated myelopathy/tropical spastic paraparesis; adult T-cell leukemia/lymphoma; inflammation; neurodegeneration; therapeutics; infectious dermatitis; cancer; antiviral drugs

(This special issue belongs to the Section Human Virology and Viral Diseases)

Viral Diseases of Major Crops

edited by Zaifeng Fan and Yan Shi

submission deadline 30 Apr 2026 | 2 articles | Viewed by 2521 | Submission Open

Keywords: viral infection; viral pathogenicity; virus movement; replication; RNA silencing suppressor; host response; host factors; molecular plant– virus– vector interactions

(This special issue belongs to the Section Viruses of Plants, Fungi and Protozoa)

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