Omics of Virus-Host Interactions

Dear Colleagues,

Viruses are obligate intracellular parasites. Thus, they must enter host cells in order to usurp cellular functions to use for their own propagation and to cause disease, during which viral components must interact with cellular components. This often results in viruses causing enormous perturbations in cellular and organismal function. These intimate interactions between viral and cellular constituents lead to both the host and the pathogen influencing each other. Significant progress has been made during the past few decades thanks to advances in technologies, gene sequencing and bioinformatics, that now allow global analyses of thousands of genes and proteins. This has allowed the unprecedented analyses of changes that take place in both the virus and the cell as they interact with each other.

In this Special Issue of Viruses, we want to compile examples of the types of analyses and studies that contribute towards a better understanding of virus–host interactions. These include, but are not limited to, new observations regarding:

• How viruses modify the cellular transcriptomic profile;
• Quantitative cellular protein alterations induced by virus infections;
• Global cellular protein modifications induced by virus infection, such as phosphorylation pattern alterations;
• Analyses of which viral proteins interact with which cellular proteins;
• Functional cellular protein alterations (e.g., activity-based protein profiling) induced by virus infection;
• Alterations in cellular pathways (e.g., apoptosis, autophagy, immune, unfolded protein response) induced by virus infection;
• Advances in technologies and in bioinformatics that contribute to better understanding virus–host interactions.

Dr. Kevin M Coombs
Guest Editor

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