Decoding Dengue Virus: Molecular Pathogenesis and Host Immunity

Dear Colleagues,

Dengue virus (DENV) remains one of the most significant mosquito-borne viral threats to global health, with hundreds of millions of infections annually. Despite decades of research, the complex interplay between viral factors and host immune responses continues to challenge our understanding of disease progression, severity, and protective immunity. This Special Issue, ‘Decoding Dengue Virus: Molecular Pathogenesis and Host Immunity’, aims to bring together research that advances our mechanistic insight into DENV biology and host–virus interactions.

We welcome original research articles, reviews, and perspectives that explore viral entry, replication strategies, immune evasion, and determinants of virulence. Submissions addressing innate and adaptive immune responses, antibody-dependent enhancement, T cell immunity, and immunopathology are particularly encouraged. We are also interested in systems-level approaches, including omics technologies, single-cell and spatial analyses, and computational modelling that shed light on host responses across tissues and disease stages.

In addition, we invite studies on vaccine- and infection-induced immunity, correlates of protection, and emerging therapeutic or immunomodulatory strategies. Research that bridges basic molecular insights with translational or clinical implications will be especially valuable.

By integrating diverse perspectives from virology, immunology, structural biology, and clinical research, this Special Issue seeks to deepen our understanding of dengue pathogenesis and inform the development of more effective interventions. We look forward to your contributions and to fostering a comprehensive dialogue that moves the field toward improved prevention and treatment of dengue disease.

Dr. Wy Ching Ng
Guest Editor

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