Innovative Approaches to GABAergic Drug Discovery: From Molecular Mechanisms to Advanced Therapeutics
A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Pharmacology".
Deadline for manuscript submissions: 25 October 2025 | Viewed by 111
Special Issue Editors
Interests: drug delivery; drug interactions; cannabinoids; legal highs; organic electronics; organic LED; perovskites
Interests: microenvironment; tumor targeting; pharmacokinetics; toxicology; telomerase; nanoparticles for drug delivery; chemotherapy
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This Special Issue invites contributions that explore the role of gamma-aminobutyric acid (GABA) in drug discovery and development. GABAergic signaling plays a pivotal role in numerous neurological and psychiatric disorders, including epilepsy, anxiety, depression, and neurodegenerative diseases. Understanding the mechanisms of GABA receptor modulation and the development of GABA-targeting therapeutics is essential for advancing treatment strategies in these areas.
We welcome studies focused on GABA receptor pharmacology, ligand design, and novel approaches to modulating GABAergic activity. Of particular interest is work integrating computational methods—such as artificial intelligence, machine learning, and structural bioinformatics—with experimental strategies, including high-throughput screening and in vivo validation.
Research into innovative drug delivery systems that enhance the efficacy, targeting, and bioavailability of GABAergic drugs is also encouraged. This includes studies of nanoparticle-based systems, liposomal formulations, and polymeric carriers designed for controlled release.
Through this Special Issue, we aim to highlight cutting-edge research that deepens our understanding of GABA’s therapeutic potential and accelerates the development of next-generation GABAergic interventions. We invite original research articles, reviews, and case studies that contribute novel insights and technological advancements to this critical area of pharmaceutical science.
Dr. Wojciech Kołodziejczyk
Dr. Donato Colangelo
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceuticals is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- GABAergic signaling
- GABA receptors
- drug discovery
- neurological and psychiatric disorders
- ligand design
- computational drug development
- artificial intelligence in pharmacology
- high-throughput screening
- targeted drug delivery
- controlled release systems
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
