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Pharmaceuticals publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Pharmacogenomics for Precision Medicine, 2nd Edition

edited by

Vacis Tatarūnas

submission deadline 23 May 2026 | 1 articles | Viewed by 607

Keywords: pharmacogenomics in precise therapy; tailored medicine; pharmacoeconomics; personalized medicine; education in pharmacogenomics and precise medicine; future directions in pharmacogenomics; pharmacogenomics and phenotype; host-bacteria interaction in pharmacogenomics; genotype; epigenetic variation; and gene expression axis in pharmacogenomics

(This special issue belongs to the Section Pharmacology)

Pediatric Drug Therapy: Safety, Efficacy, and Personalized Medicine

edited by

Catherine M. T. Sherwin

submission deadline 25 May 2026 | 9 articles | Viewed by 33388 | Submission Open

Keywords: pediatric pharmacotherapy; drug safety in children; pediatric drug efficacy; personalized medicine in pediatrics; pediatric pharmacokinetics; pediatric pharmacodynamics; pharmacogenomics in children; pediatric clinical trials; pediatric dosing strategies; pediatric drug formulations

(This special issue belongs to the Section Pharmacology)

Artificial Intelligence-Assisted Drug Discovery

edited by Aldo Sena De Oliveira

submission deadline 25 May 2026 | 5 articles | Viewed by 20047 | Submission Open

Keywords: artificial intelligence; drug discovery; machine learning; medicinal chemistry; computational chemistry; virtual screening; ADMET predictions; de novo drug design; multi-target ligands; drug repositioning

(This special issue belongs to the Section Medicinal Chemistry)

Therapeutic Methods Against Acute and Chronic Diseases and Oxidative Stress

edited by

Yanka Karamalakova

submission deadline 25 May 2026 | 6 articles | Viewed by 14019 | Submission Open

Keywords: natural antioxidant; synthetic agents; acute diseases; chronic diseases; oxidative stress

(This special issue belongs to the Section Medicinal Chemistry)

Sirtuins as Novel Biological Targets for Pharmacological Intervention in Physiology and Pathology—2nd Edition

edited by

Michele Aventaggiato

and

Marco Tafani

submission deadline 25 May 2026 | 6 articles | Viewed by 13009 | Submission Open

Keywords: sirtuins; metabolism; cancer; hypoxia; damage recovery; cell death

(This special issue belongs to the Section Pharmacology)

The Therapeutic Potential of Cannabidiol

edited by

Karolina Walczyńska-Dragon

and

Anna Kurek-Górecka

submission deadline 25 May 2026 | 5 articles | Viewed by 10901 | Submission Open

Keywords: cannabidiol; endocannabinoid system; pain; anti-inflammatory agents; muscle spasticity; pain management; chronic pain

(This special issue belongs to the Section Natural Products)

Exosome and Biotherapeutic Strategies for Dermatological and Oncological Skin Complications

edited by

Lidia Majewska

and Jacek M. Kijowski

submission deadline 25 May 2026 | 1 articles | Viewed by 10596 | Submission Open

Keywords: exosomes; skin cancer; dermatological therapy; extracellular vesicles; biotherapeutics; regenerative medicine; nanomedicine; wound healing; cancer-related skin manifestations; dermatological drug delivery; wound healing therapeutics; cutaneous oncology; exosome-based therapy

(This special issue belongs to the Section Biopharmaceuticals)

Mathematical Modeling in Drug Metabolism and Pharmacokinetics

edited by

Ziran Li

and

Dongsheng Yang

submission deadline 25 May 2026 | 6 articles | Viewed by 8924 | Submission Open

Keywords: pharmacokinetics; mathematical modeling; physiologically based pharmacokinetic (PBPK); pharmacokinetic/pharmacodynamic (PK/PD); quantitative systems pharmacology (QSP); machine learning; model-informed drug development; translational modeling; artificial intelligence (AI); personalized medicine

(This special issue belongs to the Section Medicinal Chemistry)

Research Advances in Targeted Therapy for Facial Skin Diseases

edited by

Edileia Bagatin

Marco Alexandre Rocha

and Diogo Pazzini Bomfim

submission deadline 25 May 2026 | 2 articles | Viewed by 8840 | Submission Open

Keywords: facial dermatoses; targeted therapy; biologics; precision dermatology; acne vulgaris; topical drug delivery

(This special issue belongs to the Section Pharmacology)

Infectious Disease Epidemiology and Pharmaceutical Development in the Era of Antimicrobial Resistance (AMR)

edited by Victoria Birlutiu

submission deadline 25 May 2026 | 3 articles | Viewed by 7261 | Submission Open

Keywords: antimicrobial resistance (AMR); antibiotic stewardship; multidrug-resistant organisms (MDROs); infectious disease epidemiology; rapid diagnostics; antimicrobial surveillance; therapeutic development; resistance mechanisms

(This special issue belongs to the Section Pharmacology)

Protein and Peptide-Based Drug Delivery

edited by Hoda M. Eltaher

submission deadline 25 May 2026 | 3 articles | Viewed by 6260 | Submission Open

Keywords: proteolytic degradation; chemical stability; immunogenicity; oral bioavailability; scalability; off- target; effects; bioconjugation; peptide engineering; biodegradable polymers; regulatory and clinical considerations

(This special issue belongs to the Section Biopharmaceuticals)

Innovations in Therapeutic Strategies for Retinal and Neurodegenerative Diseases

edited by

Tonking Bastola

and Won-Kyu Ju

submission deadline 25 May 2026 | 2 articles | Viewed by 5444 | Submission Open

Keywords: glaucoma; Alzheimer's diseases; retinal disease; neuroprotection; neuroinflammation

(This special issue belongs to the Section Pharmacology)

Drug Formulation: Solubilization and Controlled-Release Strategies

edited by

María Peña Fernández

submission deadline 25 May 2026 | 2 articles | Viewed by 4144 | Submission Open

Keywords: drug formulation; solubilization; controlled-release systems; solubility; poorly water-soluble drugs

(This special issue belongs to the Section Pharmaceutical Technology)

Pharmacotherapy for Alzheimer’s Disease, 2nd Edition

edited by

Gabriela Dumitrița Stanciu

submission deadline 25 May 2026 | 4 articles | Viewed by 3851 | Submission Open

Keywords: Alzheimer’ s disease; pharmacotherapy; therapeutic editing tools; repurposing existing therapeutics; multi-target-directed ligands; preclinical studies; neurodegeneration; drug development; neuroprotection; cannabinoid-based pharmaceuticals; single-molecule drugs or whole-plant extracts of Cannabis sativa L.

(This special issue belongs to the Section Pharmacology)

Antidiabetic Agents: New Drug Discovery Insights and Prospects

edited by Rosanna Maccari

submission deadline 25 May 2026 | 3 articles | Viewed by 3071 | Submission Open

Keywords: diabetes mellitus; drug design; drug discovery; drug development; drug synthesis; computational-aided drug design; molecular targets; biological activity; structure– activity relationships

(This special issue belongs to the Section Medicinal Chemistry)

Antimicrobial Therapies Affect the Microbial Ecosystems Within Our Body: The Urinary Microbiome and Urolithiasis

edited by

Loredana Sabina Cornelia Manolescu

submission deadline 25 May 2026 | 1 articles | Viewed by 2715 | Submission Open

Keywords: antibiotics; antimicrobials; resistance; microbiome; urolithiasis; biofilms; infections; pathogens; pharmacotherapy; inflammation

(This special issue belongs to the Section Pharmacology)

Natural Bioactive Substances: Microencapsulation Technologies, Pharmacological Efficacies and Sustainable Application in Pharmaceuticals

edited by

Lauryna Pudžiuvelytė

and

Mantas Stankevičius

submission deadline 25 May 2026 | 2 articles | Viewed by 1878 | Submission Open

Keywords: natural bioactive substances; microencapsulation technologies; pharmacological efficacy; sustainable pharmaceutical application; drug carrier materials; bioavailability; controlled release; green pharmacy

(This special issue belongs to the Section Pharmaceutical Technology)

Development of Specific Dosage Form: Wound Dressing, 2nd Edition

edited by

Mihaela Violeta Ghica

Madalina Georgiana Albu Kaya

Lacramioara Popa

and Cristina Elena Dinu-Pirvu

submission deadline 25 May 2026 | 1 articles | Viewed by 1341 | Submission Open

Keywords: skin lesion; wound healing; wound dressing; regenerative medicine; biomaterials; smart biopolymers; therapeutic system; controlled delivery system; scaffolds; biocompatibility

(This special issue belongs to the Section Pharmaceutical Technology)

Histamine Receptors: Ligand Design, Pharmacology, and Therapeutic Applications

edited by

Marek Staszewski

and

Krzysztof Walczyński

submission deadline 25 May 2026 | 1 articles | Viewed by 1171 | Submission Open

Keywords: histamine receptors; drug discovery; ligand design; antagonist/inverse agonist; pharmacology; therapeutic applications; multi-target directed ligands; molecular modeling

(This special issue belongs to the Section Pharmacology)

Natural Products for Treating Hypertension and Blood Sugar

edited by

Arquimedes Gasparotto Junior

and

Emerson Luiz Botelho Lourenço

submission deadline 25 May 2026 | 1 articles | Viewed by 1092 | Submission Open

Keywords: antihypertensive; diabetes; cardioprotective; herbal medicine; hypertension; medicinal plants; natural products

(This special issue belongs to the Section Natural Products)

Natural Products in Diabetes Mellitus: 3rd Edition

edited by

Ana Angélica Feregrino-Pérez

submission deadline 25 May 2026 | 1 articles | Viewed by 1059 | Submission Open

Keywords: natural products; hypoglycemia; phenolic compounds; diabetes mellitus; therapeutic; ROS

(This special issue belongs to the Section Natural Products)

Pharmacotherapy of Liver Fibrosis and Hepatitis: Recent Advances, 2nd Edition

edited by

Ching-Lung Lai

submission deadline 25 May 2026 | 1 articles | Viewed by 976 | Submission Open

Keywords: treatment of HBV; HCV; SLD; detection and prevention of liver fibrosis and HCC

(This special issue belongs to the Section Pharmacology)

Antiplatelet Therapy in Inflammatory Diseases

edited by

Patricia Pia Wadowski

submission deadline 25 May 2026 | Viewed by 569 | Submission Open

Keywords: atherosclerotic diseases; inflammatory diseases; antiplatelet therapy; platelet inhibition

(This special issue belongs to the Section Biopharmaceuticals)

Deregulated Signaling Pathways and Innovative Therapeutic Approaches in Cancer

edited by

Sofia Georgiou-Siafis

and Ioannis S. Pappas

submission deadline 25 May 2026 | Viewed by 548 | Submission Open

Keywords: anti-cancer therapeutic approaches; innovative therapeutics; molecular biology; deregulated signaling pathways; oncogenes; tumor repressor partners; antioxidant mechanisms; mAbs; targeted therapies

(This special issue belongs to the Section Pharmacology)

Pharmacotherapy of Prostate Cancer

edited by

Benyi Li

submission deadline 25 May 2026 | Viewed by 404 | Submission Open

Keywords: prostate cancer; clinical; treatment; prostate cancer imaging; targeted therapy; immunotherapy

(This special issue belongs to the Section Pharmacology)

DNA Repair Targeted Therapy: New Advances in Cancer Treatment

edited by Nimrat Chatterjee

submission deadline 25 May 2026 | Viewed by 259 | Submission Open

Keywords: DNA repair; cancer treatment; targeted therapy; gene-editing; immune-based therapies; DNA repair inhibitors; molecular targets; combination therapies

(This special issue belongs to the Section Biopharmaceuticals)

Advances in Natural Products: Basic, Therapeutic, and Computational Approaches in Chronic and Infectious Diseases

edited by

Maira Huerta-Reyes

Gil Alfonso Magos-Guerrero

Oscar Barrera-Vázquez

and

Michael Danilenko

submission deadline 26 May 2026 | 11 articles | Viewed by 37543 | Submission Open

Keywords: natural products; chronic diseases; infectious diseases; computational; in silico

(This special issue belongs to the Section Natural Products)

Computational Methods in Drug Development

edited by

Yunjie Zhao

submission deadline 26 May 2026 | 10 articles | Viewed by 34728 | Submission Open

Keywords: computational modeling; DNA/RNA and protein; drug discovery and design; systems biology; channels and membranes; biomedical data analysis; artificial intelligence; molecule docking and scoring

(This special issue belongs to the Section Medicinal Chemistry)

Sex Differences in Pharmaceutical Practice: 2nd Edition

edited by

Silvia De Francia

and

Sarah Allegra

submission deadline 28 May 2026 | Viewed by 284 | Submission Open

Keywords: sex; differences; drugs; kinetics; dynamics; preclinical; clinical; research

(This special issue belongs to the Section Medicinal Chemistry)

Recent Advances in the Discovery and Development of Drugs for Civilization Diseases, 2nd Edition

edited by

Marcin Gackowski

Karolina Szewczyk-Golec

and

Renata Studzińska

submission deadline 29 May 2026 | 9 articles | Viewed by 26144 | Submission Open

Keywords: anticancer drugs; anticancer treatment; anticoagulants; atherosclerosis; cardiovascular disease; civilization diseases; diabetes mellitus; drug development; in silico research; medication form/drug dosage form; molecular descriptors; molecular docking; molecular dynamics; molecular modeling; neoplastic disease; obesity; QSAR; radiopharmaceuticals; synthesis of bioactive compounds; type 2 diabetes

(This special issue belongs to the Section Medicinal Chemistry)

Pharmacotherapy of Dyslipidemias, 2nd Edition

edited by

Daniel Dias Rufino Arcanjo

and

Maria do Carmo de Carvalho e Martins

submission deadline 29 May 2026 | 3 articles | Viewed by 21565 | Submission Open

Keywords: atherosclerosis; dyslipidemia; endothelial dysfunction; fatty acids; high-fat diet; hyperlipidemia; hypertriglyceridemia; polyunsaturated fatty acids; PUFA; statins

(This special issue belongs to the Section Medicinal Chemistry)

Novel Therapeutic Strategies for Alzheimer’s Disease Treatment

edited by

Melvin Hayden

submission deadline 29 May 2026 | 3 articles | Viewed by 8296 | Submission Open

Keywords: Sporadic; late-onset Alzheimer’ s disease (LOAD); neurodegenerative diseases

(This special issue belongs to the Section Pharmacology)

Precision Oncology: Targeting Molecular Subtypes in Cancer Therapy

edited by

Shuhei Suzuki

and Jiro Ogura

submission deadline 29 May 2026 | 5 articles | Viewed by 7148 | Submission Open

Keywords: cancer chemotherapy; cancer genomic profiling test; next-generation sequencing; genetic variants; molecular targeted therapy; molecular tumor board; liquid biopsy

(This special issue belongs to the Section Pharmacology)

Small Molecule Drug Discovery: Driven by In-Silico Techniques

edited by

Roberta Rocca

submission deadline 29 May 2026 | 2 articles | Viewed by 4836 | Submission Open

Keywords: drug discovery; nutraceuticals; virtual screening; docking; molecular dynamics; pharmacophore; lead compound

(This special issue belongs to the Section Medicinal Chemistry)

Investigating the Therapeutic Potential of Natural Products in Internal Diseases

edited by Roberto Pontarolo and

Raul Edison Luna Lazo

submission deadline 29 May 2026 | Viewed by 336 | Submission Open |

Keywords: natural products; internal diseases; cardiovascular diseases; diabetes; autoimmune disorders; gastrointestinal conditions; respiratory illnesses

(This special issue belongs to the Section Natural Products)

Targeting Bacterial Metabolism with Natural and Synthetic Inhibitors

edited by

Mihaela Ileana Ionescu

Cristina Mariana Moldovan

and

Ovidiu Oniga

submission deadline 29 May 2026 | Viewed by 334 | Submission Open

Keywords: bacterial metabolism; protein kinases; therapeutic strategy; clinical studies; natural inhibitors; enzymatic activity; drug design; structural studies

(This special issue belongs to the Section Medicinal Chemistry)

Exploring Novel Therapies and Drug Efficacy for Inflammatory Bowel Disease

edited by

Fabiana Andréa Moura

submission deadline 30 May 2026 | 1 articles | Viewed by 1122 | Submission Open

Keywords: Crohn's disease; ulcerative colitis; pharmacology; antioxidants; novel therapies; gut microbiome; inflammation

(This special issue belongs to the Section Pharmacology)

Small-Molecule Inhibitors for Novel Therapeutics

edited by

Gustavo Provensi

and Simone Giovannuzzi

submission deadline 31 May 2026 | 4 articles | Viewed by 28648 | Submission Open

Keywords: small molecules; enzyme inhibition/activation; protein modulation; novel therapeutics; high-throughput screening; target proteins; drug delivery

New Insights of Sodium-Glucose Cotransporter 2 (SGLT2) Inhibitors in Biomedical Applications

edited by

Afif Nakhleh

, Bshara Mansour and Naim Shehadeh

submission deadline 31 May 2026 | 3 articles | Viewed by 18848 | Submission Open

Keywords: SGLT2 Inhibitors; cardiovascular protection; renal health; metabolic benefits

(This special issue belongs to the Section Pharmacology)

Comprehensive Strategies in Cancer Immunotherapy

edited by Yee Peng Phoon

submission deadline 31 May 2026 | 8 articles | Viewed by 14886 | Submission Open

Keywords: immunotherapy; CAR-T; TIL therapy; predictive biomarker; neoadjuvant; cytokine therapy; bispecific antibodies; personalized treatment; combination therapies; tumor microenvironment; immune modulation; interaction and mechanism

(This special issue belongs to the Section Pharmacology)

Drug Discovery and Development for Parasitic Diseases

edited by

Francois Dufrasne

submission deadline 31 May 2026 | 6 articles | Viewed by 12701 | Submission Open

Keywords: parasitic diseases; biological activity; synthesis; pharmacology; medicine; chemistry; target

(This special issue belongs to the Section Medicinal Chemistry)

Natural Products for Anticancer, Anti-Inflammatory and Antimicrobial Therapies

edited by Heriberto Torres-Moreno,

Julio César López-Romero

Elena Y. Enioutina

and

Max Vidal Gutiérrez

submission deadline 31 May 2026 | 5 articles | Viewed by 11169 | Submission Open

Keywords: natural products; anticancer; anti-inflammatory; antimicrobial; pharmacy; pharmacology

(This special issue belongs to the Section Natural Products)

Heterocyclic Chemistry in Modern Drug Development

edited by

Anna Kasprzycka

and

Magdalena Skonieczna

submission deadline 31 May 2026 | 3 articles | Viewed by 10316 | Submission Open

Keywords: heterocycles; drug design; drug development; green synthesis; organic synthesis; synthetic biology; enzyme inhibitors; medicinal chemistry; cell biology; in vitro assay

(This special issue belongs to the Section Medicinal Chemistry)

Application of Nanotechnology in Drug Delivery

edited by

Camila Batista Da Silva

and

Michelle Franz-Montan

submission deadline 31 May 2026 | 10 articles | Viewed by 8073 | Submission Open

Keywords: drug discovery; drug combinations; nanotechnology; drug liberation

(This special issue belongs to the Section Pharmaceutical Technology)

Novel Anticancer Drug Development and Toxicity Reduction Strategies

edited by

Monika Papież

submission deadline 31 May 2026 | 4 articles | Viewed by 7526 | Submission Open

Keywords: cancer; targeted therapy; anticancer drug; structure-based computational technique; combination therapy; nanocarriers; hydrogels

(This special issue belongs to the Section Medicinal Chemistry)

Polymers, Nanoparticles and Hydrogels for Drug Delivery: Strategies and Applications

edited by Mónica de la Luz Corea Téllez, Marlon Rojas López,

Lucia Tellez-Jurado

and Rogelio Jiménez-Juárez

submission deadline 31 May 2026 | 2 articles | Viewed by 2900 | Submission Open

Keywords: drug delivery; medical applications; hydrogels; polymers; nanoparticles; drug delivery system; multi-stimuli-responsive materials; nanocomposites; biofilms; biomarkers

(This special issue belongs to the Section Pharmaceutical Technology)

Next-Generation Antibiotic Strategies Against Drug-Resistant Bacteria

edited by

Jan Naseer Kaur

, Nicholas Smith and Parikshit Padhi

submission deadline 31 May 2026 | 2 articles | Viewed by 2808 | Submission Open

Keywords: persisters and AMR; combination pharmacotherapy; drug repurposing; antibiotic adjuvants; next-generation beta lactamase inhibitors; small molecule inhibitors; bacteriophage therapy; peptides and CRISPR-based antimicrobials; novel therapeutics; heteroresistance

(This special issue belongs to the Section Pharmacology)

Advances in Theranostic Radiopharmaceuticals

edited by

Janke Kleynhans

submission deadline 31 May 2026 | 2 articles | Viewed by 2610 | Submission Open

Keywords: theranostics; radiopharmacy; targeted alpha therapy; preclinical imaging; radiobiology; radioisotope production; molecular radiotherapy; positron emission tomography; single photon emission tomography

(This special issue belongs to the Section Radiopharmaceutical Sciences)

Targeting the NLRP3: From Novel Inhibitor Design to Clinic Trials and Therapeutic Applications

edited by

Yiming Xu

and

Yana Cen

submission deadline 31 May 2026 | Viewed by 616 | Submission Open

Keywords: NLRP3 inflammasome; selective and direct NLRP3 inhibitors; drug discovery; clinical trial; therapeutic applications

(This special issue belongs to the Section Biopharmaceuticals)

Raman Spectroscopy as a Tool for Drug Discovery, Development and Biomedical Research

edited by Panagiota Zarmpi

submission deadline 31 May 2026 | Viewed by 419 | Submission Open

Keywords: Raman spectroscopy; SERS; SORS; SRS; CARS; drug design; drug– target interaction; high-throughput; drug formulation; preformulation; bioequivalence; non-invasive biosensing

(This special issue belongs to the Section Medicinal Chemistry)

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