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Pharmaceuticals publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Therapeutic Methods Against Acute and Chronic Diseases and Oxidative Stress

edited by

Yanka Karamalakova

submission deadline 25 May 2026 | 3 articles | Viewed by 7574 | Submission Open

Keywords: natural antioxidant; synthetic agents; acute diseases; chronic diseases; oxidative stress

(This special issue belongs to the Section Medicinal Chemistry)

The Therapeutic Potential of Cannabidiol

edited by

Karolina Walczyńska-Dragon

and

Anna Kurek-Górecka

submission deadline 25 May 2026 | 2 articles | Viewed by 3529 | Submission Open

Keywords: cannabidiol; endocannabinoid system; pain; anti-inflammatory agents; muscle spasticity; pain management; chronic pain

(This special issue belongs to the Section Natural Products)

Sirtuins as Novel Biological Targets for Pharmacological Intervention in Physiology and Pathology—2nd Edition

edited by

Michele Aventaggiato

and

Marco Tafani

submission deadline 25 May 2026 | 3 articles | Viewed by 2992 | Submission Open

Keywords: sirtuins; metabolism; cancer; hypoxia; damage recovery; cell death

(This special issue belongs to the Section Pharmacology)

Innovations in Therapeutic Strategies for Retinal and Neurodegenerative Diseases

edited by

Tonking Bastola

and Won-Kyu Ju

submission deadline 25 May 2026 | 1 articles | Viewed by 2439 | Submission Open

Keywords: glaucoma; Alzheimer's diseases; retinal disease; neuroprotection; neuroinflammation

(This special issue belongs to the Section Pharmacology)

Metal Complexes in Medicinal Chemistry: From Coordination Chemistry to Pharmaceutical Applications

edited by

Laura Rodriguez-Silva

and Cristina Núñez González

submission deadline 25 May 2026 | 1 articles | Viewed by 848 | Submission Open

Keywords: medicinal inorganic chemistry; metallodrugs; coordination compounds; bioinorganic chemistry; anticancer agents; antimicrobial agents; therapeutic applications; diagnostic applications; bioactive metal complexes; drug development

(This special issue belongs to the Section Medicinal Chemistry)

Antidiabetic Agents: New Drug Discovery Insights and Prospects

edited by Rosanna Maccari

submission deadline 25 May 2026 | Viewed by 157 | Submission Open

Keywords: diabetes mellitus; drug design; drug discovery; drug development; drug synthesis; computational-aided drug design; molecular targets; biological activity; structure– activity relationships

(This special issue belongs to the Section Medicinal Chemistry)

Research Advances in Targeted Therapy for Facial Skin Diseases

edited by

Edileia Bagatin

Marco Alexandre Rocha

and Diogo Pazzini Bomfim

submission deadline 25 May 2026 | Viewed by 94 | Submission Open

Keywords: facial dermatoses; targeted therapy; biologics; precision dermatology; acne vulgaris; topical drug delivery

(This special issue belongs to the Section Pharmacology)

Deregulated Signaling Pathways and Innovative Therapeutic Approaches in Cancer

edited by

Sofia Georgiou-Siafis

and Ioannis S. Pappas

submission deadline 25 May 2026 | Viewed by 81 | Submission Open

Keywords: anti-cancer therapeutic approaches; innovative therapeutics; molecular biology; deregulated signaling pathways; oncogenes; tumor repressor partners; antioxidant mechanisms; mAbs; targeted therapies

(This special issue belongs to the Section Pharmacology)

Natural Products in Diabetes Mellitus: 3rd Edition

edited by

Ana Angelica Feregrino-Perez

submission deadline 25 May 2026 | Viewed by 76 | Submission Open

Keywords: natural products; hypoglycemia; phenolic compounds; diabetes mellitus; therapeutic; ROS

(This special issue belongs to the Section Natural Products)

Advances in Solid-Phase Peptide and Oligonucleotide Synthesis: Methods, Mechanisms, and Therapeutic Applications

edited by

Danah AlShaer

and

Rakesh Tiwari

submission deadline 25 May 2026 | Viewed by 75 | Submission Open

Keywords: solid-phase peptide synthesis (SPPS); oligonucleotide synthesis; hybrid chemical– enzymatic methods; peptide therapeutics; drug design and discovery; sustainable synthesis; automation and process optimization; resin and linker chemistry; post-synthetic modification; structure– activity relationships

(This special issue belongs to the Section Biopharmaceuticals)

Natural Bioactive Substances: Microencapsulation Technologies, Pharmacological Efficacies and Sustainable Application in Pharmaceuticals

edited by

Lauryna Pudžiuvelytė

and

Mantas Stankevičius

submission deadline 25 May 2026 | 1 articles | Viewed by 64 | Submission Open

Keywords: natural bioactive substances; microencapsulation technologies; pharmacological efficacy; sustainable pharmaceutical application; drug carrier materials; bioavailability; controlled release; green pharmacy

(This special issue belongs to the Section Pharmaceutical Technology)

Hepatitis B and Delta Virus Infections: Mechanistic Insights and Clinical Drug Therapy

edited by Daniele Lombardo

submission deadline 25 May 2026 | Viewed by 63 | Submission Open

Keywords: chronic hepatitis B; hepatitis delta virus coinfection; hepatocellular carcinoma risk; antiviral drug development; HBV functional cure strategies; immune modulation in hepatitis; pharmacological therapies for viral hepatitis

(This special issue belongs to the Section Pharmacology)

Impact of Drug Transporter Gene Variation on Pharmacokinetics and Clinical Outcomes in Chronic Disease Therapy

edited by

Fernando De Andrés

and

Pedro Dorado

submission deadline 25 May 2026 | Viewed by 60 | Submission Open

Keywords: drug transporter gene variants; chronic diseases; pharmacokinetics; clinical therapeutic effects; individualized medication; ABCB1; SLC22A family; SLCO1B1

(This special issue belongs to the Section Pharmacology)

Natural Products for Treating Hypertension and Blood Sugar

edited by

Arquimedes Gasparotto Junior

and

Emerson Luiz Botelho Lourenço

submission deadline 25 May 2026 | Viewed by 58 | Submission Open

Keywords: antihypertensive; diabetes; cardioprotective; herbal medicine; hypertension; medicinal plants; natural products

(This special issue belongs to the Section Natural Products)

Histamine Receptors: Ligand Design, Pharmacology, and Therapeutic Applications

edited by

Marek Staszewski

and

Krzysztof Walczyński

submission deadline 25 May 2026 | Viewed by 56 | Submission Open

Keywords: histamine receptors; drug discovery; ligand design; antagonist/inverse agonist; pharmacology; therapeutic applications; multi-target directed ligands; molecular modeling

(This special issue belongs to the Section Pharmacology)

Peptide-Based Therapeutics: Targeting Amylin, Calcitonin, and Related Receptors

edited by

Sangmin Lee

and

Predrag Sikirić

submission deadline 25 May 2026 | Viewed by 44 | Submission Open

Keywords: GPCR; amylin; obesity; diabetes; peptide-based drugs; long-acting agonists

(This special issue belongs to the Section Biopharmaceuticals)

Development of Specific Dosage Form: Wound Dressing, 2nd Edition

edited by

Mihaela Violeta Ghica

Madalina Georgiana Albu Kaya

Lacramioara Popa

and Cristina Elena Dinu-Pirvu

submission deadline 25 May 2026 | Viewed by 35 | Submission Open

Keywords: skin lesion; wound healing; wound dressing; regenerative medicine; biomaterials; smart biopolymers; therapeutic system; controlled delivery system; scaffolds; biocompatibility

(This special issue belongs to the Section Pharmaceutical Technology)

DNA Repair Targeted Therapy: New Advances in Cancer Treatment

edited by Nimrat Chatterjee

submission deadline 25 May 2026 | Viewed by 22 | Submission Open

Keywords: DNA repair; cancer treatment; targeted therapy; gene-editing; immune-based therapies; DNA repair inhibitors; molecular targets; combination therapies

(This special issue belongs to the Section Biopharmaceuticals)

Natural Products for the Treatment of Prostate Cancer

edited by

Maria Loreta Libero

and

Annalisa Chiavaroli

submission deadline 25 May 2026 | Viewed by 12 | Submission Open

Keywords: prostate cancer; natural compounds; plants; urinary tract infections; supplements; signaling pathways

(This special issue belongs to the Section Natural Products)

The Role of Phytochemicals in Aging and Aging-Related Diseases, 2nd Edition

edited by

Giovanni Scapagnini

Sergio Davinelli

and

Alessandro Medoro

submission deadline 25 May 2026 | Submission Open

Keywords: phytochemicals; plant-based diet; dietary supplementation; pharma-nutrition; aging; aging-related diseases; prevention

(This special issue belongs to the Section Natural Products)

Application of Nuclear Magnetic Resonance (NMR) in Drug Development

edited by Vladimir M. Gelev

submission deadline 25 May 2026 | Submission Open

Keywords: biomolecular NMR; drug discovery; library screening using NMR; SAR using NMR; fragment-based drug discovery using NMR

(This special issue belongs to the Section Pharmaceutical Technology)

Emerging Biomarkers in Autoimmune Diseases: From Pharmacodynamic Insights to Therapeutic Translation

edited by

Kornelia Kuźnik-Trocha

submission deadline 25 May 2026 | Submission Open

Keywords: autoimmune diseases; emerging biomarkers; pharmacodynamic biomarkers; therapeutic translation; precision pharmacotherapy; immunomodulators; biologics; treatment response prediction; adverse drug reaction monitoring; omics in pharmacology; rheumatoid arthritis/inflammatory bowel disease

(This special issue belongs to the Section Biopharmaceuticals)

Computational Methods in Drug Development

edited by

Yunjie Zhao

submission deadline 26 May 2026 | 9 articles | Viewed by 22081 | Submission Open

Keywords: computational modeling; DNA/RNA and protein; drug discovery and design; systems biology; channels and membranes; biomedical data analysis; artificial intelligence; molecule docking and scoring

(This special issue belongs to the Section Medicinal Chemistry)

Sex Differences in Pharmaceutical Practice: 2nd Edition

edited by

Silvia De Francia

and

Sarah Allegra

submission deadline 28 May 2026 | Viewed by 64 | Submission Open

Keywords: sex; differences; drugs; kinetics; dynamics; preclinical; clinical; research

(This special issue belongs to the Section Medicinal Chemistry)

Pharmacotherapy of Dyslipidemias, 2nd Edition

edited by

Daniel Dias Rufino Arcanjo

and

Maria do Carmo de Carvalho e Martins

submission deadline 29 May 2026 | 3 articles | Viewed by 13419 | Submission Open

Keywords: atherosclerosis; dyslipidemia; endothelial dysfunction; fatty acids; high-fat diet; hyperlipidemia; hypertriglyceridemia; polyunsaturated fatty acids; PUFA; statins

(This special issue belongs to the Section Medicinal Chemistry)

Recent Advances in the Discovery and Development of Drugs for Civilization Diseases, 2nd Edition

edited by

Marcin Gackowski

Karolina Szewczyk-Golec

and

Renata Studzińska

submission deadline 29 May 2026 | 6 articles | Viewed by 8717 | Submission Open

Keywords: anticancer drugs; anticancer treatment; anticoagulants; atherosclerosis; cardiovascular disease; civilization diseases; diabetes mellitus; drug development; in silico research; medication form/drug dosage form; molecular descriptors; molecular docking; molecular dynamics; molecular modeling; neoplastic disease; obesity; QSAR; radiopharmaceuticals; synthesis of bioactive compounds; type 2 diabetes

(This special issue belongs to the Section Medicinal Chemistry)

Novel Therapeutic Strategies for Alzheimer’s Disease Treatment

edited by

Melvin Hayden

submission deadline 29 May 2026 | 1 articles | Viewed by 5240 | Submission Open

Keywords: Sporadic; late-onset Alzheimer’ s disease (LOAD); neurodegenerative diseases

(This special issue belongs to the Section Pharmacology)

Small Molecule Drug Discovery: Driven by In-Silico Techniques

edited by

Roberta Rocca

submission deadline 29 May 2026 | 1 articles | Viewed by 3354 | Submission Open

Keywords: drug discovery; nutraceuticals; virtual screening; docking; molecular dynamics; pharmacophore; lead compound

(This special issue belongs to the Section Medicinal Chemistry)

Precision Oncology: Targeting Molecular Subtypes in Cancer Therapy

edited by

Shuhei Suzuki

and Jiro Ogura

submission deadline 29 May 2026 | 3 articles | Viewed by 2899 | Submission Open

Keywords: cancer chemotherapy; cancer genomic profiling test; next-generation sequencing; genetic variants; molecular targeted therapy; molecular tumor board; liquid biopsy

(This special issue belongs to the Section Pharmacology)

Investigating the Therapeutic Potential of Natural Products in Internal Diseases

edited by Roberto Pontarolo and

Raul Edison Luna Lazo

submission deadline 29 May 2026 | Viewed by 8 | Submission Open

Keywords: natural products; internal diseases; cardiovascular diseases; diabetes; autoimmune disorders; gastrointestinal conditions; respiratory illnesses

(This special issue belongs to the Section Natural Products)

Exploring Novel Therapies and Drug Efficacy for Inflammatory Bowel Disease

edited by

Fabiana Andréa Moura

submission deadline 30 May 2026 | Viewed by 92 | Submission Open

Keywords: Crohn's disease; ulcerative colitis; pharmacology; antioxidants; novel therapies; gut microbiome; inflammation

(This special issue belongs to the Section Pharmacology)

Small-Molecule Inhibitors for Novel Therapeutics

edited by

Gustavo Provensi

and Simone Giovannuzzi

submission deadline 31 May 2026 | 4 articles | Viewed by 19186 | Submission Open

Keywords: small molecules; enzyme inhibition/activation; protein modulation; novel therapeutics; high-throughput screening; target proteins; drug delivery

Novel Anticancer Drug Development and Toxicity Reduction Strategies

edited by

Monika Papież

submission deadline 31 May 2026 | 3 articles | Viewed by 3556 | Submission Open

Keywords: cancer; targeted therapy; anticancer drug; structure-based computational technique; combination therapy; nanocarriers; hydrogels

(This special issue belongs to the Section Medicinal Chemistry)

Next-Generation Antibiotic Strategies Against Drug-Resistant Bacteria

edited by

Jan Naseer Kaur

, Nicholas Smith and Parikshit Padhi

submission deadline 31 May 2026 | 1 articles | Viewed by 1335 | Submission Open

Keywords: persisters and AMR; combination pharmacotherapy; drug repurposing; antibiotic adjuvants; next-generation beta lactamase inhibitors; small molecule inhibitors; bacteriophage therapy; peptides and CRISPR-based antimicrobials; novel therapeutics; heteroresistance

(This special issue belongs to the Section Pharmacology)

Polymers, Nanoparticles and Hydrogels for Drug Delivery: Strategies and Applications

edited by Mónica de la Luz Corea Téllez, Marlon Rojas López,

Lucia Tellez-Jurado

and Rogelio Jiménez-Juárez

submission deadline 31 May 2026 | 2 articles | Viewed by 572 | Submission Open

Keywords: drug delivery; medical applications; hydrogels; polymers; nanoparticles; drug delivery system; multi-stimuli-responsive materials; nanocomposites; biofilms; biomarkers

(This special issue belongs to the Section Pharmaceutical Technology)

Targeting the NLRP3: From Novel Inhibitor Design to Clinic Trials and Therapeutic Applications

edited by

Yiming Xu

and

Yana Cen

submission deadline 31 May 2026 | Viewed by 138 | Submission Open

Keywords: NLRP3 inflammasome; selective and direct NLRP3 inhibitors; drug discovery; clinical trial; therapeutic applications

(This special issue belongs to the Section Biopharmaceuticals)

Advances in Theranostic Radiopharmaceuticals

edited by

Janke Kleynhans

submission deadline 31 May 2026 | Viewed by 134 | Submission Open

Keywords: theranostics; radiopharmacy; targeted alpha therapy; preclinical imaging; radiobiology; radioisotope production; molecular radiotherapy; positron emission tomography; single photon emission tomography

(This special issue belongs to the Section Radiopharmaceutical Sciences)

Applications of Stem Cells and Organoids in Disease Modeling, Drug Discovery and Clinical Evaluation

edited by Daniela Omodei

submission deadline 31 May 2026 | Viewed by 114 | Submission Open

Keywords: stem cells; patient-derived cells; iPSCs (induced pluripotent stem cells); organoids; drug development; drug screening; drug toxicity; preclinical and clinical drug research; novel therapeutics; disease modeling; personalized medicine; precision medicine

(This special issue belongs to the Section Pharmacology)

Drug Candidates for the Treatment of Obesity, 3rd Edition

edited by

Maria Isabel Cardoso Alonso-Vale

and

Monica Marques Telles

submission deadline 31 May 2026 | Viewed by 54 | Submission Open

Keywords: obesity ; appetite supressors ; nutraceuticals ; plant extracts ; lipid metabolism ; high-fat diet ; adipogenesis

(This special issue belongs to the Section Medicinal Chemistry)

Pharmacological Treatments for Parasitic Diseases

edited by Maria Dichiara and

Giuliana Costanzo

submission deadline 31 May 2026 | Viewed by 34 | Submission Open

Keywords: parasitic diseases; antiparasitic agents; drug resistance; therapeutic strategies; drug discovery; neglected tropical diseases (NTDs); medicinal chemistry; global health

(This special issue belongs to the Section Medicinal Chemistry)

Anti-Fbibrosis Agent Development

edited by Younghwa Na

submission deadline 31 May 2026 | Viewed by 32 | Submission Open

Keywords: idiopathic pulmonary fibrosis (IPF); anti-fibrosis; drug discovery; combination therapies; personalized medicine

(This special issue belongs to the Section Medicinal Chemistry)

Emerging Technologies and Therapeutic Innovations for Neglected Tropical Diseases

edited by

Sandra Elisa Haas

submission deadline 31 May 2026 | Viewed by 12 | Submission Open

Keywords: neglected tropical diseases; nanoparticles; drug delivery systems; one health; therapeutic optimization; molecular targets; precision medicine; machine learning; artificial intelligence

(This special issue belongs to the Section Pharmaceutical Technology)

Raman Spectroscopy as a Tool for Drug Discovery, Development and Biomedical Research

edited by Panagiota Zarmpi

submission deadline 31 May 2026 | Submission Open

Keywords: Raman spectroscopy; SERS; SORS; SRS; CARS; drug design; drug– target interaction; high-throughput; drug formulation; preformulation; bioequivalence; non-invasive biosensing

(This special issue belongs to the Section Medicinal Chemistry)

Epigenetic Regulatory Mechanisms and Applications of Non-Coding RNAs in Chemoresistance and Metabolic Disorders

edited by

Pía Loren Reyes

, Francisca Villagrán-Silva and Pablo J. Letelier

submission deadline 15 Jun 2026 | Viewed by 97 | Submission Open

Keywords: non-coding RNAs; epigenetic regulation; chemoresistance; metabolic disorders; chemotherapy-related toxicities; DNA methylation; histone modification; chromatin remodeling; RNA-based therapeutics; biomarkers

(This special issue belongs to the Section Biopharmaceuticals)

Allosteric Modulators: Unlocking New Dimensions from Molecular Discovery to Therapeutic Potential

edited by

Changho Han

Lisa Barbaro

and Kwangho Kim

submission deadline 20 Jun 2026 | Viewed by 87 | Submission Open

Keywords: allosteric binding sites; protein– ligand interactions; mechanism of action; isoform selectivity; signal bias; structure-based design; pharmacological profiling; allosteric anchoring; GPCRs; ion channels; kinases; heterobifunctional ligand; allosteric synergy

(This special issue belongs to the Section Medicinal Chemistry)

Tumor Therapy and Drug Delivery: 2nd Edition

edited by

Rositsa Mihaylova

submission deadline 20 Jun 2026 | Viewed by 21 | Submission Open

Keywords: antitumor therapy; drug-delivery systems; nanocarriers; immunoconjugates; nanotechnology; cancer selectivity

(This special issue belongs to the Section Pharmaceutical Technology)

Pharmaceutical Applications of Cannabinoids

edited by

Eduarda M. P. Silva

and

Carlos Ribeiro

submission deadline 25 Jun 2026 | 1 articles | Viewed by 1492 | Submission Open

Keywords: cannabis; cannabinoids; therapeutic properties; medicinal plant; phytochemicals

Epidemiological Surveillance of Clinical Bacterial Infections and Antimicrobial Resistance Management

edited by

Davide Carcione

and

Dario Cattaneo

submission deadline 25 Jun 2026 | Viewed by 58 | Submission Open

Keywords: antimicrobial resistance (AMR); clinical bacterial infections; epidemiological surveillance; antimicrobial stewardship (AMS); drug-resistant pathogens; rapid diagnostic tools for AMR; pharmacokinetics/pharmacodynamics (PK/PD) of antimicrobials; infection control; multi-center surveillance data; public health policy for AMR

(This special issue belongs to the Section Pharmacology)

Extracellular Vesicles and Bioinspired Nanovesicles as Next-Generation Drug-Delivery Systems

edited by

Jagannath Mondal

submission deadline 25 Jun 2026 | Submission Open

Keywords: extracellular vesicles; bioinspired nanovesicles; drug-delivery systems; therapeutics; exosomes; exosome-like nanoparticles; hybrid exosomes

(This special issue belongs to the Section Biopharmaceuticals)

Self-Assembling Materials for Next-Generation Biopharmaceuticals

edited by

Leming Sun

submission deadline 25 Jun 2026 | Submission Open

Keywords: peptide self-assembly; peptide drug design; drug-loaded nanostructures; biomaterials; AI-driven design

(This special issue belongs to the Section Biopharmaceuticals)

Displaying special issue 301-350 on page 7 of 8.

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