Special Issue "Natural Products and Human Health: Current Understanding and Application"

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Phytochemicals and Human Health".

Deadline for manuscript submissions: 30 April 2021.

Special Issue Editors

Dr. Raffaella Canali

Guest Editor
Research Centre for Food and Nutrition, Consiglio per la Ricerca in Agricoltura e l'Analisi dell'Economia Agraria (CREA), Roma, Italy
Dr. Fausta Natella
Website
Guest Editor
Research Centre for Food and Nutrition, Consiglio per la Ricerca in Agricoltura e l'Analisi dell'Economia Agraria (CREA), Roma, Italy

Special Issue Information

Dear Colleagues,

Natural products (NPs) are rich source of therapeutic agents utilized in both traditional and modern medicine for treating diseases and maintaining health. For this reason, NPs are regarded as an important repository for the development of potential novel drugs.

This Special Issue aims to present novel findings documenting the pharmacological and/or biological activity of NPs products. In particular, we intend to focus on the physiological, biochemical, and molecular processes underlying the mechanism of action of NPs in in vitro and in vivo studies related to human nutrition. The submission of studies aimed at characterizing the bioavailability and the biological effect of NP metabolites will also be welcomed. Research paper on original products, extracts, and single molecules will be considered. We invite clinicians and researchers to submit relevant scientific work, in the form of either original articles, short communications or reviews, to this Special Issue of Nutrients on “Natural Products and Human Health: Current Understanding and Application”.

Dr. Raffaella Canali
Dr. Fausta Natella
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Natural Products
  • Bioactive Molecules
  • Human Health
  • Disease Prevention
  • Bioavailability
  • Metabolites
  • Molecular And Physiological Mechanism
  • Gut Microbiota

Published Papers (2 papers)

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Research

Open AccessArticle
St. John’s Wort Suppresses Growth in Triple-Negative Breast Cancer Cell Line MDA-MB-231 by Inducing Prodeath Autophagy and Apoptosis
Nutrients 2020, 12(10), 3175; https://doi.org/10.3390/nu12103175 - 17 Oct 2020
Abstract
The rational regulation of programmed cell death by means of autophagy and apoptosis has been considered a potential treatment strategy for cancer. We demonstrated the inhibitory effect of St. John’s Wort (SJW) on growth in the triple-negative breast cancer (TNBC) cell line and [...] Read more.
The rational regulation of programmed cell death by means of autophagy and apoptosis has been considered a potential treatment strategy for cancer. We demonstrated the inhibitory effect of St. John’s Wort (SJW) on growth in the triple-negative breast cancer (TNBC) cell line and xenografted mice and its target mechanism concerning autophagic and apoptotic cell death. SJW ethanol extract (SJWE) inhibited proliferation in a dose-dependent manner. SJWE treatment dramatically increased autophagy flux and apoptosis compared with the control. The autophagy inhibitor, 3-methyladenine (3-MA), reversed the SJWE-induced inhibition of cell proliferation and regulation of autophagy and apoptosis, indicating that SJWE induced apoptosis through prodeath autophagy. Furthermore, SJWE inhibited tumor growth and induced autophagy and apoptosis in the tumor of MDA-MB-231 xenografted athymic nude mice. Our results indicate that SJWE might have great potential as a new anticancer therapy for triple-negative breast cancer by inducing prodeath autophagy and apoptosis. Full article
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Open AccessArticle
Research Quality-Based Multivariate Modeling for Comparison of the Pharmacological Effects of Black and Red Ginseng
Nutrients 2020, 12(9), 2590; https://doi.org/10.3390/nu12092590 - 26 Aug 2020
Abstract
Black ginseng has various pharmacological activities, but only few studies have compared its pharmacological effects with those of red ginseng. We conducted an integrative systematic literature evaluation and developed a non-inferiority test based on the multivariate modeling approach to compare the pharmacological effects [...] Read more.
Black ginseng has various pharmacological activities, but only few studies have compared its pharmacological effects with those of red ginseng. We conducted an integrative systematic literature evaluation and developed a non-inferiority test based on the multivariate modeling approach to compare the pharmacological effects of red ginseng and black ginseng. We searched reported studies on the pharmaceutical effects and composition of ginsenosides and assigned numeric scores using nonlinear principal component analysis, based on discretization measures for the included publications. Downstream weighted linear regression models were constructed to study the eight major biological activities that are generally known to be exhibited by red ginseng. Our statistical model, based on available ordinal information gathered from previous literature, helped in comparing the overlapping effects of black ginseng. Black ginseng showed antioxidant effects comparable to those of red ginseng; however, this variant was inferior to red ginseng in enhancing immunity, relieving fatigue, alleviating depression/anxiety, decreasing body fat, and reducing blood pressure. We have showed a cost-efficient method to indirectly evaluate the biological effects of ginseng products using data from published articles. This method can also be used to compare the nutritional and medicinal value of herbal medicines that share similar compositions of bioactive compounds. Full article
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