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Open AccessArticle

St. John’s Wort Suppresses Growth in Triple-Negative Breast Cancer Cell Line MDA-MB-231 by Inducing Prodeath Autophagy and Apoptosis

1
Department of Nutrition, University of Massachusetts Amherst, Amherst, MA 01003, USA
2
Department of Food and Nutrition, Mokpo National University, Jeollanam-do 58554, Korea
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(10), 3175; https://doi.org/10.3390/nu12103175
Received: 7 September 2020 / Revised: 11 October 2020 / Accepted: 15 October 2020 / Published: 17 October 2020
The rational regulation of programmed cell death by means of autophagy and apoptosis has been considered a potential treatment strategy for cancer. We demonstrated the inhibitory effect of St. John’s Wort (SJW) on growth in the triple-negative breast cancer (TNBC) cell line and xenografted mice and its target mechanism concerning autophagic and apoptotic cell death. SJW ethanol extract (SJWE) inhibited proliferation in a dose-dependent manner. SJWE treatment dramatically increased autophagy flux and apoptosis compared with the control. The autophagy inhibitor, 3-methyladenine (3-MA), reversed the SJWE-induced inhibition of cell proliferation and regulation of autophagy and apoptosis, indicating that SJWE induced apoptosis through prodeath autophagy. Furthermore, SJWE inhibited tumor growth and induced autophagy and apoptosis in the tumor of MDA-MB-231 xenografted athymic nude mice. Our results indicate that SJWE might have great potential as a new anticancer therapy for triple-negative breast cancer by inducing prodeath autophagy and apoptosis. View Full-Text
Keywords: triple-negative breast cancer; autophagy; apoptosis; St. John’s Wort triple-negative breast cancer; autophagy; apoptosis; St. John’s Wort
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You, M.; Lee, Y.-H.; Kim, H.-J.; Kook, J.H.; Kim, H.-A. St. John’s Wort Suppresses Growth in Triple-Negative Breast Cancer Cell Line MDA-MB-231 by Inducing Prodeath Autophagy and Apoptosis. Nutrients 2020, 12, 3175.

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