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Special Issue Information

Dear Colleagues,

Gout is a form of inflammatory joint disease that affects many people. It is characterized by hyperuricemia, which has long been linked to purine metabolism or renal excretion of uric acid. Uric acid is the result of a breakdown of purines, which is a substance found naturally in body tissues and many foods. Genetics, sex, age, medical conditions, obesity, certain dietary factors and drugs have all been linked to an increased chance of developing gout. However, emerging evidence indicates an association between gut microbiome and arthritis diseases, including gout.

The first aim of this Special Issue is to update knowledge on the relationship between diet and hyperuricemia, focusing on dietary factors associated with anti-inflammatory effects. The second aim is to explore the effects of dietary interventions for gout on cardiovascular risk and renal insufficiency. In addition, we will explore novel associations with the microbiome. We welcome different types of manuscript submissions, including original research articles and up-to-date reviews (systematic reviews and meta-analyses).

Dr. Amedeo Amedei
Dr. Camilla Fiorindi
Dr. Francesco Giudici
Dr. Edda Russo
Guest Editors

Manuscript Submission Information

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Keywords

gout
hyperuricemia
purine
anti-inflammatory diet
specific diet
obesity
renal insufficiency
cardiovascular risk
microbiome

Published Papers (2 papers)

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Research

Jump to: Review

15 pages, 1117 KiB

Open AccessArticle

Potential Association of Osteoporosis and Not Osteoporotic Fractures in Patients with Gout: A Longitudinal Follow-Up Study

by Mi Jung Kwon, Jae Yong Park, Sung Gyun Kim, Jwa-Kyung Kim, Hyun Lim, Joo-Hee Kim, Ji Hee Kim, Seong-Jin Cho, Eun Sook Nam, Ha Young Park, Nan Young Kim and Ho Suk Kang

Nutrients 2023, 15(1), 134; https://doi.org/10.3390/nu15010134 - 28 Dec 2022

Cited by 6 | Viewed by 2251

Abstract

Health issues associated with gout and increased occurrence of osteoporosis or fractures have been raised; however, the results are elusive. Herein, we explored the possible link between gout and incident osteoporosis/osteoporotic fractures based on long-term follow-up nationwide data. This study enrolled 16,305 patients with gout and 65,220 controls who were matched by propensity score at a 1:4 ratio on the basis of sex, age, income, and residence from the Korean National Health Insurance Service-Health Screening Cohort database (2002–2015). A Cox proportional hazard model was employed to identify the relevance between gout and incident osteoporosis/fractures, following adjustment for various covariates. In the follow-up period, osteoporosis developed in 761 individuals with gout and 2805 controls (incidence rates: 8.0 and 7.3/1000 person-years, respectively), and each osteoporotic fracture in the distal radius (2.8 vs. 2.7/1000 person-years), hip (1.3 vs. 1.3/1000 person-years), and spine (4.5 vs. 4.5/1000 person-years) occurred in gout and control groups, respectively. After adjustment, the gout group presented an 11% higher development of osteoporosis (95% confidence interval = 1.02–1.20) than the controls (p = 0.011). Subgroup analyses maintained the augment of incident osteoporosis in sufferers with gout, particularly in either men or <60 years. However, no such relevance was identified between gout and incident osteoporotic fractures at any site. In conclusion, gout may result in a slightly elevated likelihood of developing osteoporosis, and not osteoporotic fractures, in the Korean population. Full article

(This article belongs to the Special Issue Dietary Approaches in Care and Prevention Gout and Associated Diseases)

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Graphical abstract

Review

Jump to: Research

22 pages, 1945 KiB

Open AccessReview

Gout and Diet: A Comprehensive Review of Mechanisms and Management

by Yingling Zhang, Simin Chen, Man Yuan, Yu Xu and Hongxi Xu

Nutrients 2022, 14(17), 3525; https://doi.org/10.3390/nu14173525 - 26 Aug 2022

Cited by 17 | Viewed by 14563

Abstract

Gout is well known as an inflammatory rheumatic disease presenting with arthritis and abnormal metabolism of uric acid. The recognition of diet-induced systemic metabolic pathways have provided new mechanistic insights and potential interventions on gout progression. However, the dietary recommendations for gouty patients generally focus on food categories, with few simultaneous considerations of nutritional factors and systemic metabolism. It is worthwhile to comprehensively review the mechanistic findings and potential interventions of diet-related nutrients against the development of gout, including purine metabolism, urate deposition, and gouty inflammation. Although piecemeal modifications of various nutrients often provide incomplete dietary recommendations, understanding the role of nutritional factors in gouty development can help patients choose their healthy diet based on personal preference and disease course. The combination of dietary management and medication may potentially achieve enhanced treatment effects, especially for severe patients. Therefore, the role of dietary and nutritional factors in the development of gout is systematically reviewed to propose dietary modification strategies for gout management by: (1) reducing nutritional risk factors against metabolic syndrome; (2) supplementing with beneficial nutrients to affect uric acid metabolism and gouty inflammation; and (3) considering nutritional modification combined with medication supplementation to decrease the frequency of gout flares. Full article

(This article belongs to the Special Issue Dietary Approaches in Care and Prevention Gout and Associated Diseases)

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