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Human Milk, Nutrition and Infant Development

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Pediatric Nutrition".

Deadline for manuscript submissions: 25 August 2025 | Viewed by 2045

Special Issue Editors


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Guest Editor
Department of Physiology and Toxicology, Faculty of Biological Sciences, Kazimierz Wielki University, Chodkiewicza 30 St., 85-064 Bydgoszcz, Poland
Interests: newborns and infants nutrition; lactation; human milk banking; donor milk; human milk processing; infant development; breastmilk bioactive compounds and microbiota; childhood obesity

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Guest Editor
Stead Family Department of Pediatrics, University of Iowa, Iowa City, IA 52242, USA
Interests: breast milk; oral feeding; prematurity; preterm infants; complementary feeds
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Special Issue Information

Dear Colleagues,

Human milk and its impact on infant development is a topic widely discussed in scientific and medical literature, and has highlighted the critical role of breast milk in infant health and development. Mother's milk is regarded as the gold standard of infant nutrition, with research into its composition and effects underscoring its significant nutritional and protective value. Nutrition during infancy profoundly influences health later in life, and substantial benefits are associated with breastfeeding and the use of milk from human milk banks. The importance of breastfeeding cannot be overstated, particularly for preterm infants, though the benefits extend to all children.

The composition of human milk is variable and depends, among other things, on maternal and environmental factors. A key consideration is the bioavailability of its active compounds and their role in optimal infant development. Despite advances in infant formula, replicating the full spectrum of properties found in breast milk remains a challenge, making breast milk the preferred source of nutrition in the first months of life.

In addition to providing essential nutrients, breast milk actively supports infant health by delivering unique bioactive components. It plays a critical role in protecting against infections, supporting neurological development, regulating appetite and promoting a healthy gut microbiota. Research into components such as human milk oligosaccharides (HMOs) and human milk miRNA continues to reveal the significance of this unique food in human development.

This Special Issue invites original studies, literature reviews and meta-analyses exploring the composition and biological role of human milk in child development, with a particular focus on the following topics:

  • The composition of human milk, including donor milk, and its health benefits for infants;
  • The effect of human milk on the development of the digestive, nervous and immune systems;
  • Challenges in human milk research;
  • Human milk epigenetics and long-term health benefits.

Dr. Elena Sinkiewicz-Darol
Prof. Dr. Robert D. Roghair
Guest Editors

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • human milk
  • human milk processing
  • donor milk
  • infant feeding
  • personalized infant nutrition
  • lactation
  • human milk microbiota
  • human milk epigenetics
  • infant development

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Published Papers (1 paper)

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Review

57 pages, 5684 KiB  
Review
Human Milk Oligosaccharides: Decoding Their Structural Variability, Health Benefits, and the Evolution of Infant Nutrition
by Hatice Duman, Mikhael Bechelany and Sercan Karav
Nutrients 2025, 17(1), 118; https://doi.org/10.3390/nu17010118 - 30 Dec 2024
Cited by 3 | Viewed by 1737
Abstract
Human milk oligosaccharides (HMOs), the third most abundant solid component in human milk, vary significantly among women due to factors such as secretor status, race, geography, season, maternal nutrition and weight, gestational age, and delivery method. In recent studies, HMOs have been shown [...] Read more.
Human milk oligosaccharides (HMOs), the third most abundant solid component in human milk, vary significantly among women due to factors such as secretor status, race, geography, season, maternal nutrition and weight, gestational age, and delivery method. In recent studies, HMOs have been shown to have a variety of functional roles in the development of infants. Because HMOs are not digested by infants, they act as metabolic substrates for certain bacteria, helping to establish the infant’s gut microbiota. By encouraging the growth of advantageous intestinal bacteria, these sugars function as prebiotics and produce short-chain fatty acids (SCFAs), which are essential for gut health. HMOs can also specifically reduce harmful microbes and viruses binding to the gut epithelium, preventing illness. HMO addition to infant formula is safe and promotes healthy development, infection prevention, and microbiota. Current infant formulas frequently contain oligosaccharides (OSs) that differ structurally from those found in human milk, making it unlikely that they would reproduce the unique effects of HMOs. However, there is a growing trend in producing OSs resembling HMOs, but limited data make it unclear whether HMOs offer additional therapeutic benefits compared to non-human OSs. Better knowledge of how the human mammary gland synthesizes HMOs could direct the development of technologies that yield a broad variety of complex HMOs with OS compositions that closely mimic human milk. This review explores HMOs’ complex nature and vital role in infant health, examining maternal variation in HMO composition and its contributing factors. It highlights recent technological advances enabling large-scale studies on HMO composition and its effects on infant health. Furthermore, HMOs’ multifunctional roles in biological processes such as infection prevention, brain development, and gut microbiota and immune response regulation are investigated. The structural distinctions between HMOs and other mammalian OSs in infant formulas are discussed, with a focus on the trend toward producing more precise replicas of HMOs found in human milk. Full article
(This article belongs to the Special Issue Human Milk, Nutrition and Infant Development)
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