Effects of Probiotics and Prebiotics on Gut-Brain Axis
A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Prebiotics and Probiotics".
Deadline for manuscript submissions: 25 January 2026 | Viewed by 11
Special Issue Editors
2. Department of Biomedicine, Neuroscience and Advanced Diagnostics, University of Palermo, Palermo, Italy
Interests: molecular chaperones; chaperonopathies; chaperonotherapy; gut microbiota; gut–brain axis; extracellular vesicles; outer membrane vesicles (OMVs); tissue homeostasis
Interests: anatomy; oxidative stress; molecular chaperones; cell signaling; cell biology; bioinformatics
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The gut–brain axis represents a dynamic communication network between the gastrointestinal tract and the central nervous system, playing a key role in regulating behavior, cognition, and emotional health. Increasing evidence highlights how probiotics and prebiotics can beneficially modulate this axis by influencing the composition and activity of the gut microbiota, with downstream effects on neurological and psychological outcomes.
This Special Issue, “Effects of Probiotics and Prebiotics on Gut-Brain Axis”, aims to gather high-quality contributions that explore how microbiota-targeted dietary interventions can impact brain function and mental health. We welcome original research, systematic reviews, and meta-analyses addressing both mechanistic and clinical aspects.
Topics of interest include, but are not limited to:
- The impact of specific probiotics and prebiotics on mood, cognition, and neurodevelopment;
- Microbial metabolites and their neuromodulatory roles;
- The influence of the gut microbiota on neuroinflammatory and neurodegenerative processes;
- Clinical interventions targeting the microbiota in psychiatric or neurological disorders;
- The role of diet in shaping gut–brain interactions across the lifespan.
We encourage submissions from diverse disciplines, including nutrition, neuroscience, microbiology, and psychiatry. Your work will contribute to advancing the understanding of how nutritional modulation of the microbiota may support brain health.
We look forward to receiving your valuable contributions to this Special Issue.
Dr. Letizia Paladino
Dr. Antonella Marino Gammazza
Guest Editors
Manuscript Submission Information
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Keywords
- gut–brain axis
- probiotics
- prebiotics
- microbiota
- neuroinflammation
- cognitive function
- depression
- dietary interventions
- psychobiotics
- brain health
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