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The Role of Nutritional Interventions in the Prevention and Management of Osteoarthritis

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Clinical Nutrition".

Deadline for manuscript submissions: 20 January 2026 | Viewed by 501

Special Issue Editors


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Guest Editor
Department of Biochemical Sciences “Alessandro Rossi Fanelli”, “Sapienza” University of Rome, Piazzale Aldo Moro, 5, 00185 Rome, Italy
Interests: bioactive natural compounds; herbal products; inflammatory processes; intracellular pathways; extracellular matrix components; N-acetyl-glucosamine; acetyl-carnitine; nanomaterials
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Biochemical Sciences “Alessandro Rossi Fanelli”, “Sapienza” University of Rome, Piazzale Aldo Moro, 5, 00185 Rome, Italy
Interests: osteoarthritis; inflammatory processes; extracellular matrix structure; chondrocytes; synoviocytes; osteoblasts; joint structure; miRNA; extreme environmental; nanoparticles; natural substances; intracellular pathways
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In this Special Issue, we would like to focus on the effects of both diet and nutraceutical supplementation to prevent and/or manage Osteoarthritis. OA regards approximately 8-10% of the world population with ages between 60 and 64, but it can affect also younger people with heavy social–economic impact. The etiology of OA is multifactorial, and some lifestyles can be involved in the onset and progression of OA. In particular, overweight and obesity are important modifiable risk factors in the etiopathogenesis of OA. Thus, eating habits deserve to be explored both for their harmful and beneficial effects. Manuscripts regarding diets that can be detrimental to joint structure, such as saturated fats or high-sugar foods, or diets that can have disease-fighting power versus OA, such as the Mediterranean diet, are welcome. Moreover, manuscripts on plant or herbal extracts as well as on isolated components, both in bulk and nanoparticle forms, or synthetic molecules resembling natural ones are welcome too. Discussions on the appropriateness of certain foods rather than others are particularly welcome. This Special Issue aims to shed light on the role of diet and dietary components in regulating the metabolic processes involved in the development and progression of OA.

Dr. Anna Scotto D'Abusco
Dr. Alessia Mariano
Guest Editors

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Keywords

  • osteoarthritis
  • saturated fat diet
  • Mediterranean diet
  • plant extract
  • herbal extract
  • isolated natural molecules
  • synthetic molecules
  • nanoparticles
  • inflammatory processes

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Published Papers (1 paper)

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Research

19 pages, 2543 KB  
Article
Impact of Nutritional Status on Clinical Outcomes of Patients Undergoing PRGF Treatment for Knee Osteoarthritis—A Prospective Observational Study
by Paola De Luca, Giulio Grieco, Simona Landoni, Eugenio Caradonna, Valerio Pascale, Enrico Ragni and Laura de Girolamo
Nutrients 2025, 17(19), 3134; https://doi.org/10.3390/nu17193134 - 30 Sep 2025
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Abstract
Background: Osteoarthritis (OA) is a major global health issue, increasing with aging and obesity. Current therapies mainly address symptoms without modifying disease progression. Platelet-rich growth factor (PRGF) therapy has potential regenerative effects through high cytokines and growth factors, but the outcomes of these [...] Read more.
Background: Osteoarthritis (OA) is a major global health issue, increasing with aging and obesity. Current therapies mainly address symptoms without modifying disease progression. Platelet-rich growth factor (PRGF) therapy has potential regenerative effects through high cytokines and growth factors, but the outcomes of these therapies remain heterogeneous. This study explores the relationship between patient nutritional status, PRGF characteristics, and clinical outcomes in knee OA treatment. Methods: Baseline anthropometric, metabolic, and nutritional assessments of 41 patients with knee OA who underwent PRGF treatment were conducted. Blood samples were analyzed for metabolic and inflammatory markers. PRGF composition was assessed by protein content and extracellular vesicle (EV) markers. KOOS and VAS pain scores were collected at 2, 6, and 12 months. Responders improved KOOS by ≥10 points. An elastic-net regularized logistic model allowed the identification of the predictors of treatment response. Results: KOOS and VAS scores improved significantly at all follow-ups. At 2 months, the PRGF of responder patients showed higher PRGF G-CSF levels; at 12 months, increased CD49e and HLA-ABC expression. Higher BMI correlated with increased IL-6, IL-1ra, and resistin in PRGF samples. Hypercholesterolemic patients displayed altered EV profiles, with elevated levels of CD8 but reduced CD49e, HLA-ABC, CD42a, and CD31. Multivariate analysis identified BMI, biceps fold, fat percentage, red blood cell, platelet, and neutrophil counts as predictors of early response. Conclusions: Metabolic and immunological factors influence PRGF composition and clinical efficacy in knee OA. Baseline body composition and hematological parameters as key predictors of response, highlighting the potential of personalized PRGF therapy. Full article
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