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Dietary Supplementation in Stroke Care

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Clinical Nutrition".

Deadline for manuscript submissions: 20 June 2025 | Viewed by 97

Special Issue Editor


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Guest Editor
Institute of Biomedicine of Seville (IBiS), Hospital Universitario Virgen Macarena, CSIC, Universidad de Sevilla, 41013 Seville, Spain
Interests: stroke care and management; nutrition; prevention; gender;stroke thrombolysis

Special Issue Information

Dear Colleagues,

Stroke is one of the leading causes of disability worldwide, and its management presents significant clinical challenges. While traditional risk factors such as hypertension, diabetes, and smoking are well-established, emerging evidence suggests that dietary factors and supplementation may play an important role in reducing stroke risk. Dietary supplementation is gaining attention as a complementary approach to traditional stroke prevention strategies. Research has highlighted how certain nutrients can modulate key pathways involved in stroke pathophysiology, such as endothelial function and platelet aggregation, which can help lower the risk of ischemic events. However, despite promising findings, evidence for the efficacy of specific supplements in care remains inconclusive, and further studies are needed to identify optimal dosages and combinations.

This Special Issue will include manuscripts that focus on dietary supplementation for stroke management. The content is aimed at clinical practitioners and healthcare providers, offering valuable insights into the role of dietary supplementation in stroke prevention and management. Additionally, it seeks to inspire further innovative research to explore new strategies for reducing stroke risk and improving patient outcomes through dietary interventions.

Dr. Soledad Pérez-Sánchez
Guest Editor

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Keywords

  • dietary supplementation
  • stroke
  • prevention
  • management
  • nutrients

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Published Papers (1 paper)

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Research

14 pages, 2479 KiB  
Article
Fatty Acid Ratios Versus Conventional Risk Factors in Stroke: Insights into Severe Disability and Mortality Outcomes
by Sebastian Andone, Farczádi Lénárd, Silvia Imre, Mihai Dumitreasa and Rodica Bălașa
Nutrients 2025, 17(9), 1518; https://doi.org/10.3390/nu17091518 (registering DOI) - 30 Apr 2025
Abstract
Objective: This study aims to investigate the role of fatty acid ratios, specifically DHA/ARA and EPA/ARA, in predicting severe disability and mortality in stroke patients and compare these ratios with conventional risk factors such as age, sex, hypertension, diabetes, and dyslipidemia. Methods [...] Read more.
Objective: This study aims to investigate the role of fatty acid ratios, specifically DHA/ARA and EPA/ARA, in predicting severe disability and mortality in stroke patients and compare these ratios with conventional risk factors such as age, sex, hypertension, diabetes, and dyslipidemia. Methods: A prospective study was conducted involving 298 consecutive acute ischemic stroke patients (within 72 h of onset). Fatty acid ratios were measured from plasma, and all patients’ evolution was followed through hospitalization. Binary logistic regression analysis was used to identify predictors of severe disability at discharge (Rankin 4–6) and in-hospital mortality, including fatty acid ratios and conventional risk factors. Results: A higher DHA/ARA ratio was associated with a reduced chance of severe disability (OR = 0.81), while a higher EPA/ARA ratio was associated with an increased chance of severe disability (OR = 1.70). Age was a significant factor, with older age (median 70 years) associated with a lower survivability chance (OR = 0.93) and a higher likelihood of severe disability when surviving. Fatty acid ratios did not significantly affect mortality outcomes. For male patients, EPA/AA ratios showed a powerful association with severe disability (p = 0.045), while no significant effect of fatty acids was observed in females. Conclusions: Fatty acids were significant predictors of severe disability in patients with acute ischemic stroke, independent of conventional risk factors, but without having any effect on in-hospital mortality. Age remained the only significant conventional risk factor predictor of outcome. Integrating fatty acid ratios alongside conventional risk factors may improve predictions of severe post-stroke disability, potentially guiding more personalized interventions for stroke patients. Full article
(This article belongs to the Special Issue Dietary Supplementation in Stroke Care)
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