Special Issue "Nutrition and Atherosclerosis: From Bench to Bedside"

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Clinical Nutrition".

Deadline for manuscript submissions: 30 August 2021.

Special Issue Editor

Dr. Rita Castro
Guest Editor
1. Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA, USA
2. Faculty of Pharmacy, Universidade de Lisboa, Lisboa, Portugal
Interests: homocysteine; one-carbon metabolism; endothelial dysfunction; atherosclerosis; inborn errors of methionine metabolism; methylation; nutrition
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

Atherosclerosis is the main cause of cardiovascular disease (CVD), which despite significant advances in treatment, remains the leading cause of mortality among adults. Atherosclerosis is elicited by the impairment of endothelial function and results in a chronic inflammatory condition in which arteries harden through the build-up of plaques, profoundly disturbing vascular homeostasis. A healthy dietary pattern is a cornerstone of CVD prevention and management, although the mechanistic underpinnings of dietary-pattern-related CVD risk reduction are not well understood. Nevertheless, plant-based diets and phytochemicals have been associated with improvement in atheroma plaque at an inflammatory level. Moreover, dietary micronutrient intake drives metabolic pathways that have emerged as key regulators of endothelial cell functions, which are deregulated during atherogenesis. For example, nutritional deficiencies in certain B vitamins that are co-factors for enzymes in the methionine metabolism can impact cell methylations reactions and on the different layers of related epigenetic regulation, promoting a pro-atherogenic phenotype.

This Special Issue aims to collect a set of articles directly or indirectly related to the influence of nutrition in atherosclerosis and cardiometabolic health. We welcome different types of manuscript submissions, including original research articles and up-to-date reviews (including systematic reviews and meta-analyses).

Dr. Rita Castro
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Epigenetics
  • Endothelial dysfunction
  • Inflammation
  • Plant-based diets
  • Cardiometabolic markers
  • Vitamins and cardiometabolic health
  • Atherosclerosis and cardiovascular disease
  • Phytochemicals
  • Homocysteine
  • Nutraceuticals

Published Papers

This special issue is now open for submission.
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