Special Issue "Nutrition on Endothelial Function"

A special issue of Nutrients (ISSN 2072-6643).

Deadline for manuscript submissions: 31 December 2019.

Special Issue Editor

Prof. Emilio Ros
E-Mail Website
Guest Editor
CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain
Lipid Clinic, Department of Endocrinology and Nutrition, Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Hospital Clínic, Barcelona, Spain
Interests: nutrition in the prevention of cardiovascular diseases and cognitive decline with special interest in the Mediterranean diet and walnuts; plant sterols; blood membrane fatty acids; genetic dyslipidemias; cardiovascular risk assessment; and vascular imaging techniques, especially carotid ultrasound
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Special Issue Information

Dear Colleagues,

Endothelial dysfunction is a critical cardiovascular risk marker and a central component in the development and progression of atherosclerosis. It is characterized by impaired endothelium-dependent vasodilatation, usually through the reduced availability of nitrous oxide, as well as endothelial activation, leading to the release into the circulation of soluble adhesion molecules and other pro-inflammatory mediators. Either via the modulation of cardiovascular risk factors or by a direct effect on the endothelium or both, dietary components can have a profound influence on endothelial function, however knowledge of this critical diet–disease relationship is still fragmentary.

This Special Issue of Nutrients, entitled “Nutrition and Endothelial Function”, welcomes the submission of manuscripts either describing original research or reviewing the scientific literature, including systematic reviews and meta-analyses. The proposed manuscripts should cover the effects of nutrients, foods, or dietary patterns on endothelial function, assessed in the arterial bed, with circulating molecules, or both, and either in the fasting state or postprandially.

Dr. Emilio Ros
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Endothelial function
  • Vascular reactivity
  • Flow-mediated vasodilation
  • Vascular adhesion molecules
  • Nutrients
  • Foods
  • Dietary patterns

Published Papers (1 paper)

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Research

Open AccessArticle
Effect of Alpha-Lipoic Acid Supplementation on Endothelial Function and Cardiovascular Risk Factors in Overweight/Obese Youths: A Double-Blind, Placebo-Controlled Randomized Trial
Nutrients 2019, 11(2), 375; https://doi.org/10.3390/nu11020375 - 12 Feb 2019
Cited by 1
Abstract
Endothelial dysfunction is recognized as an early sign of systemic atherosclerosis, and it represents a therapeutic target to prevent long-term cardiovascular (CV) consequences. Alpha-lipoic acid (ALA) is a commonly used dietary supplement exerting anti-oxidant and anti-inflammatory effects. We investigated whether a three-month treatment [...] Read more.
Endothelial dysfunction is recognized as an early sign of systemic atherosclerosis, and it represents a therapeutic target to prevent long-term cardiovascular (CV) consequences. Alpha-lipoic acid (ALA) is a commonly used dietary supplement exerting anti-oxidant and anti-inflammatory effects. We investigated whether a three-month treatment with ALA improves endothelial function, as assessed by flow-mediated dilation (FMD) of the brachial artery, and clinical and metabolic risk factors in overweight/obese youths. We enrolled 67 overweight/obese children, and 22 normal-weight metabolically healthy controls. Overweight/obese youths were randomly allocated in a double-blinded manner to receive ALA (n = 34) or placebo (n = 33). Of these, 64 (32 ALA, 32 placebo) completed the follow-up. At baseline, in ALA and placebo groups, FMD was similar, but lower as compared with that in controls (p = 0.045). At three months, within the ALA and placebo groups, FMD did not change significantly. However, the basal and peak diameter of brachial artery significantly increased after ALA treatment as compared to placebo (p = 0.036 and p = 0.01, respectively). There were no significant within- and between-group changes for anthropometric and metabolic variables. The results show that ALA supplementation improves vascular tone and may have a beneficial effect on CV health in overweight/obese youths. Full article
(This article belongs to the Special Issue Nutrition on Endothelial Function)
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