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Bioactive Compounds from Food: Nanotechnology Approaches for Improving Human Health

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Phytochemicals and Human Health".

Deadline for manuscript submissions: closed (25 September 2023) | Viewed by 7970

Special Issue Editors


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Guest Editor
1. Graduate Program in Veterinary Hygiene (PPGHV), Faculty of Veterinary Medicine, Fluminense Federal University (UFF), Vital Brazil Filho, Niterói 24230-340, RJ, Brazil
2. Center for Food Analysis (NAL), Technological Development Support Laboratory (LADETEC), Federal University of Rio de Janeiro (UFRJ), Cidade Universitária, Rio de Janeiro 21941-901, RJ, Brazil
3. Laboratory of Advanced Analysis in Biochemistry and Molecular Biology (LAABBM), Department of Biochemistry, Federal University of Rio de Janeiro (UFRJ), Cidade Universitária, Rio de Janeiro 21941-909, RJ, Brazil
Interests: food control; antimicrobial resistance genes; genomic; microbiome; animal production
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Guest Editor
1. Center for Food Analysis (NAL), Technological Development Support, Laboratory (LADETEC), Federal University of Rio de Janeiro (UFRJ), Cidade Universitária, Rio de Janeiro 21941-901, RJ, Brazil
2. Laboratory of Advanced Analysis in Biochemistry and Molecular Biology (LAABBM), Department of Biochemistry, Federal University of Rio de Janeiro (UFRJ), Cidade Universitária, Rio de Janeiro 21941-909, RJ, Brazil
Interests: chemistry; polymers; nanotechnology; drug delivery systems; food science and technology; bioactive compounds; antioxidants

Special Issue Information

Dear Colleagues,

Food bioactive compounds include a broad class of phytochemicals (e.g., polyphenols, carotenoids, glucosinolates, terpenoids, alkaloids, saponins, vitamins, fibres, among others) that are present in vegetables, fruits, and cereal grains and capable of modulating metabolic processes and promoting human health. These compounds have been widely associated with their ability to reduce the risk of diseases, including cancer, cardiovascular disease, neurodegenerative diseases, hypertension, and diabetes. However, their low solubility and bioavailability may decrease their preventive/therapeutic potential. To overcome these challenges, several nano-delivery systems for bioactive compounds have been proposed in recent years, including nanoemulsions, liposomes, niosomes, polymeric nanoparticles, solid lipid nanoparticles, nanostructured lipid carriers, micelles, and natural polysaccharides-based nanocarriers. Nanoencapsulated bioactive compounds promote faster absorption and improve their ability to penetrate the mucus layer or directly absorb cells. In this context, investigating novel nanotechnology approaches based on the nanoencapsulation of bioactive molecules that promote human health has greatly interested the scientific community. Thus, this Special Issue of Nutrients, entitled “Bioactive Compounds from Food: Nanotechnology Approaches for Improving Human Health”, welcomes high-quality original studies and review articles that examine nanotechnology's impact on improving the effectiveness of delivering food bioactive compounds to improve human health.

Prof. Dr. Carlos Adam Conte Júnior
Dr. Italo Rennan Sousa Vieira
Guest Editors

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bioactive compounds
  • functional foods
  • herbal medicine
  • human health
  • cancer
  • cardiovascular disorders
  • neurodegenerative diseases
  • nano-delivery systems
  • nanotechnology
  • nanocarriers
  • nanoparticles

Published Papers (3 papers)

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Research

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21 pages, 5049 KiB  
Article
Enhancing the Antioxidant, Antibacterial, and Wound Healing Effects of Melaleuca alternifolia Oil by Microencapsulating It in Chitosan-Sodium Alginate Microspheres
by Anbazhagan Sathiyaseelan, Xin Zhang and Myeong-Hyeon Wang
Nutrients 2023, 15(6), 1319; https://doi.org/10.3390/nu15061319 - 7 Mar 2023
Cited by 5 | Viewed by 2092
Abstract
In this study, antibacterial and antioxidant molecules-rich Melaleuca alternifolia oil (tea tree oil (TTO)) loaded chitosan (CS) based nanoemulsions (NEMs) were prepared and encapsulated by sodium alginate (SA) microsphere for antibacterial wound dressing. CS-TTO NEMs were prepared by oil-in-water emulsion technique, and the [...] Read more.
In this study, antibacterial and antioxidant molecules-rich Melaleuca alternifolia oil (tea tree oil (TTO)) loaded chitosan (CS) based nanoemulsions (NEMs) were prepared and encapsulated by sodium alginate (SA) microsphere for antibacterial wound dressing. CS-TTO NEMs were prepared by oil-in-water emulsion technique, and the nanoparticle tracking analysis (NTA) confirmed that the CS-TTO NEMs had an average particle size of 89.5 nm. Further, the SA-CS-TTO microsphere was confirmed through SEM analysis with an average particle size of 0.76 ± 0.10 µm. The existence of TTO in CS NEMs and SA encapsulation was evidenced through FTIR analysis. The XRD spectrum proved the load of TTO and SA encapsulation with CS significantly decreased the crystalline properties of the CS-TTO and SA-CS-TTO microsphere. The stability of TTO was increased by the copolymer complex, as confirmed through thermal gravimetric analysis (TGA). Furthermore, TTO was released from the CS–SA complex in a sustained manner and significantly inhibited the bacterial pathogens observed under confocal laser scanning microscopy (CLSM). In addition, CS-TTO (100 µg/mL) showed antioxidant potential (>80%), thereby increasing the DPPH and ABTS free radicals scavenging ability of SA-CS-TTO microspheres. Moreover, CS and SA-CS-TTO microsphere exhibited negligible cytotoxicity and augmented the NIH3T3 cell proliferation confirmed in the in vitro scratch assay. This study concluded that the SA-CS-TTO microsphere could be an antibacterial and antioxidant wound dressing. Full article
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Review

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42 pages, 4561 KiB  
Review
Recent Progress in Nanotechnology Improving the Therapeutic Potential of Polyphenols for Cancer
by Italo Rennan Sousa Vieira, Leticia Tessaro, Alan Kelbis Oliveira Lima, Isabela Portella Silva Velloso and Carlos Adam Conte-Junior
Nutrients 2023, 15(14), 3136; https://doi.org/10.3390/nu15143136 - 13 Jul 2023
Cited by 13 | Viewed by 3446
Abstract
Polyphenols derived from fruits, vegetables, and plants are bioactive compounds potentially beneficial to human health. Notably, compounds such as quercetin, curcumin, epigallocatechin-3-gallate (EGCG), and resveratrol have been highlighted as antiproliferative agents for cancer. Due to their low solubility and limited bioavailability, some alternative [...] Read more.
Polyphenols derived from fruits, vegetables, and plants are bioactive compounds potentially beneficial to human health. Notably, compounds such as quercetin, curcumin, epigallocatechin-3-gallate (EGCG), and resveratrol have been highlighted as antiproliferative agents for cancer. Due to their low solubility and limited bioavailability, some alternative nanotechnologies have been applied to encapsulate these compounds, aiming to improve their efficacy against cancer. In this comprehensive review, we evaluate the main nanotechnology approaches to improve the therapeutic potential of polyphenols against cancer using in vitro studies and in vivo preclinical models, highlighting recent advancements in the field. It was found that polymeric nanomaterials, lipid-based nanomaterials, inorganic nanomaterials, and carbon-based nanomaterials are the most used classes of nanocarriers for encapsulating polyphenols. These delivery systems exhibit enhanced antitumor activity and pro-apoptotic effects, particularly against breast, lung, prostate, cervical, and colorectal cancer cells, surpassing the performance of free bioactive compounds. Preclinical trials in xenograft animal models have revealed decreased tumor growth after treatment with polyphenol-loaded delivery systems. Moreover, the interaction of polyphenol co-delivery systems and polyphenol–drug delivery systems is a promising approach to increase anticancer activity and decrease chemotherapy side effects. These innovative approaches hold significant implications for the advancement of clinical cancer research. Full article
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23 pages, 6556 KiB  
Review
Nanotechnology Promoting the Development of Products from the Biodiversity of the Asteraceae Family
by Raíssa Mara Kao Yien, Ana Paula dos Santos Matos, Anne Caroline Candido Gomes, Denise de Abreu Garófalo, Ralph Santos-Oliveira, Naomi Kato Simas and Eduardo Ricci-Júnior
Nutrients 2023, 15(7), 1610; https://doi.org/10.3390/nu15071610 - 26 Mar 2023
Cited by 3 | Viewed by 1785
Abstract
Biodiversity is a hallmark of the Asteraceae family. Several species are known for their pharmacological potential. The search for new substances has permeated the chemistry of natural products for years. However, the development of a final product is still a challenge. Plant extracts [...] Read more.
Biodiversity is a hallmark of the Asteraceae family. Several species are known for their pharmacological potential. The search for new substances has permeated the chemistry of natural products for years. However, the development of a final product is still a challenge. Plant extracts have physicochemical characteristics that sometimes hinder administration, requiring a formulation. In this context, nanotechnology emerges as a tool to improve the pharmacokinetic parameters of several pharmacologically active substances. Nanoemulsions, liposomes, and nanoparticles are used to carry the active ingredients and thus improve therapeutic action, especially for substances with solubility and absorption problems. This paper aimed at compiling all the studies that used nanotechnology to develop formulations from species of the Asteraceae family from 2010 to 2021 in a literature review. The search showed that nanoemulsions are the most developed formulation associated with essential oils. The use of nanotechnology promoted an improvement in the pharmacokinetic parameters of active substances. Full article
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