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Fuel and Flow: The Science of Diet-Exercise Interplay in Heart Health

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Metabolism".

Deadline for manuscript submissions: 25 April 2026 | Viewed by 879

Special Issue Editors


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Guest Editor
1. Department of Sports, Higher Institute of Educational Sciences of the Douro, 4560-708 Penafiel, Portugal
2. Research Center for Active Living and Wellbeing (LiveWell), Instituto Politécnico de Bragança, 5300-253 Bragança, Portugal
3. Department of Sports, Instituto Politécnico de Bragança, 5300-253 Bragança, Portugal
4. CI-ISCE, ISCE Douro, 4560-708 Penafiel, Portugal
Interests: chronic pain; physical exercise; sports science
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Guest Editor
Laboratory of Cardiovascular Physiology and Reactive Oxygen Species, Physiology Department, Institute of Basic Health Science (ICBS), Federal University of Rio Grande do Sul (UFRGS), Porto Alegre 90010-150, RS, Brazil
Interests: cardiovascular diseases; antioxidants; microbiology; nutrition; diet
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Nutrition and Health, Universidade Federal de Viçosa, Viçosa 36570-900, MG, Brazil
Interests: analysis of total phenolics in foods and extracts; intestinal health; sports nutrition; nutrition; diet
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Cardiovascular health is profoundly influenced by both dietary patterns and physical activity behaviors. Emerging evidence underscores the synergistic effects of nutrition and exercise on vascular function, lipid metabolism, inflammation, and overall cardiac performance. This Special Issue, “Fuel and Flow: The Science of Diet-Exercise Interplay in Heart Health,” aims to explore the integrated role of diet and exercise in the prevention, management, and rehabilitation of cardiovascular diseases.

We welcome original research, reviews, and meta-analyses that investigate how specific dietary interventions (e.g., Mediterranean, DASH, plant-based, ketogenic, or supplementation strategies) interact with various forms of physical activity (aerobic, resistance, high-intensity interval training, or neuromotor exercise) to impact cardiovascular biomarkers, heart rate variability, endothelial function, arterial stiffness, and overall cardiovascular outcomes. Special attention will be given to interdisciplinary and translational studies that bridge clinical, physiological, and nutritional sciences, as well as those considering age, sex, and comorbidity-specific approaches. This Special Issue serves as a platform for advancing holistic, evidence-based strategies to promote cardiovascular resilience and reduce disease burden through integrated lifestyle interventions.

Dr. Pedro Miguel Forte
Dr. Patrick Türck
Prof. Dr. Ceres Mattos Della Lucia
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • heart
  • health
  • nutrition
  • exercise
  • lifestyle
  • medicine

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Published Papers (1 paper)

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Research

27 pages, 2741 KB  
Article
Resistance Exercise Associated with Camu-Camu (Myrciaria dubia) and Creatine Supplementation Modulates Antioxidant Response and Cardiac Parameters in Wistar Rats
by Thaís Cupertino Fialho, Lívia Carvalho Sette Abrantes, Karina Vitória Cipriana Martins, Renner Philipe Rodrigues Carvalho, Camilo José Ramírez-López, Alex Filipe Ramos de Sousa, Luiz Otávio Guimarães-Ervilha, Lívya Alves Oliveira, Gabrieli Fernandes Lacerda, Ana Júlia Brandão Moreira, Sebastião Felipe Ferreira Costa, Valéria Silva de Lana, Mariana Machado-Neves, Antônio José Natali, Pedro Forte, Luciano Bernardes Leite, Izabela Maria Montezano Carvalho, Hércia Stampini Duarte Martino, Renê Chagas da Silva and Ceres Mattos Della Lucia
Nutrients 2025, 17(22), 3587; https://doi.org/10.3390/nu17223587 - 17 Nov 2025
Viewed by 689
Abstract
Background: Resistance exercise (RE) is recognized for promoting the development of muscle strength and mass, as well as contributing positively to cardiovascular health. The combination of this type of exercise with the intake of foods rich in bioactive compounds, such as camu-camu ( [...] Read more.
Background: Resistance exercise (RE) is recognized for promoting the development of muscle strength and mass, as well as contributing positively to cardiovascular health. The combination of this type of exercise with the intake of foods rich in bioactive compounds, such as camu-camu (Myrciaria dubia), and creatine supplementation may be an interesting strategy to enhance the cardiovascular system. Objective: This study aimed to evaluate the effects of RE and supplementation with camu-camu and creatine on oxidative balance, mineral content, ATPase enzyme activity, and histological changes in the heart of Wistar rats. Methods: Forty-eight adult rats were divided into eight groups, with or without RE. The groups received a control diet (AIN-93M), camu-camu (200 mg/kg/day), creatine (300 mg/kg for 7 days and 50 mg/kg/day thereafter), or a combination of both. The RE protocol was performed on a vertical ladder three times a week for eight weeks. At the end, the animals were anesthetized and euthanized for tissue collection. Results: The trained control group that received a standard diet (AIN-T) showed greater activity of superoxide dismutase and catalase. The trained group receiving creatine and camu-camu supplementation (CC + Cr-T) showed higher total antioxidant capacity (FRAP), increased Mg2+-ATPase activity, higher nitric oxide levels, and a greater diameter of cardiac muscle fibers. No pathological changes were observed in heart histology in any group, indicating preservation of tissue integrity. Conclusions: RE associated with camu-camu and creatine supplementation may be an effective strategy for modulating antioxidant and functional aspects of the heart. Full article
(This article belongs to the Special Issue Fuel and Flow: The Science of Diet-Exercise Interplay in Heart Health)
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