Special Issue "Anthocyanins and Human Health"

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Phytochemicals and Human Health".

Deadline for manuscript submissions: 20 June 2022 | Viewed by 1750

Special Issue Editors

Dr. Matteo Bordiga
E-Mail Website
Guest Editor
Dipartimento di Scienze del Farmaco, Università degli Studi del Piemonte Orientale “A. Avogadro”, Largo Donegani 2, 28100 Novara, Italy
Interests: food chemistry; gas chromatography; liquid chromatography; mass spectrometry; polyphenols; volatile compounds; wine chemistry; extraction; fermentation; prebiotic compounds
Special Issues, Collections and Topics in MDPI journals
Dr. Mar Vilanova de la Torre
E-Mail Website
Guest Editor
Institute of grape and wine science (ICVV-CSIC) Finca la Grajera,Burgos road km 6, 26080 logrono, la Rioja, Spain
Interests: grape and wine quality; volatile composition; sensory analysis; abiotic stress effect on grape quality; sustainable viticulture
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Anthocyanins are the most widespread group of pigmented flavonoids and are responsible for the red, purple, and blue colors of many fruits, vegetables and flowers. They are one of the most important natural pigments, and, up to now, more than 600 water-soluble anthocyanins have been identified in the plant kingdom. About 90% of the anthocyanin molecules are derived from the six major anthocyanidin compounds: cyanidin, delphinidin, malvidin, pelargonidin, peonidin and petunidin by glycosylations, acylations, methylation and hydroxylation. Anthocyanins can be found in almost all land plants. They function as phytoprotective substances, have a role in plant–animal interactions and, as such, are important in ecophysiology or plant defense mechanisms. Recently, interest in anthocyanins has strongly increased because of their possible health benefits as dietary antioxidants. The beneficial effects, such as anti-inflammatory and anti-carcinogenic activity, cardiovascular disease prevention, obesity control, and diabetes alleviation properties for human health have been documented in many publications. The dietary consumption of anthocyanins is high due to their occurrence in fruits and vegetables.

In this context, the aim of the present Special Issue is to highlight the diverse bioactivities of anthocyanins. This Special Issue welcomes clinical trials, epidemiological studies, and experiments conducted in cell or in vitro models that examine the potential health benefits of anthocyanins and anthocyanin-rich foods.

Dr. Matteo Bordiga
Dr. Mar Vilanova de la Torre
Guest Editors

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Anthocyanins
  • Colorant
  • Health benefit
  • Pigment
  • Flavonoids
  • Berries
  • Inflammation
  • Gut health
  • Cardiovascular disease
  • Metabolic syndrome anthocyanidins
  • Bioavailability
  • Antioxidants
  • Biological activity.

Published Papers (2 papers)

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Research

Article
Anthocyanins in Red Jasmine Rice (Oryza sativa L.) Extracts and Efficacy on Inhibition of Herpes Simplex Virus, Free Radicals and Cancer Cell
Nutrients 2022, 14(9), 1905; https://doi.org/10.3390/nu14091905 - 01 May 2022
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Abstract
Rice is one of the most important food crops in many countries, with nutritional value and health benefits. In this study, the ethanolic and aqueous extracts of red jasmine rice from Chiang Mai, Thailand were examined for their anthocyanins and phenolic contents. The [...] Read more.
Rice is one of the most important food crops in many countries, with nutritional value and health benefits. In this study, the ethanolic and aqueous extracts of red jasmine rice from Chiang Mai, Thailand were examined for their anthocyanins and phenolic contents. The antioxidant and antiviral activity against herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2), as well as anticancer activity, were investigated. The total anthocyanins content of 708.03 ± 11.56 mg Cy-3-glc equivalent/g extract, determined from the ethanolic extract, was higher than the aqueous extract. However, the aqueous extract showed the highest total phenolic compound of 81.91 ± 0.51 mg GAE/g extract. In addition, the ethanolic extract demonstrated higher antioxidant activity than aqueous extract using DPPH, ABTS, and FRAP assays by 28.91 ± 3.26 mg GAE/g extract, 189.45 ± 11.58 mg 24 TEAC/g extract, and 3292.46 ± 259.64 g FeSO4/g extract, respectively. In the antiviral assay, it was found that the ethanolic extract of red jasmine rice could inhibit HSV-1 more effectively than HSV-2 when treated before, during, and after the viral attachment on Vero cells, with 50% effective doses of 227.53 ± 2.41, 189.59 ± 7.76, and 192.62 ± 2.40 µg/mL, respectively. The extract also demonstrated the highest reduction of HSV-1 particles at 4 h after treatment and the inhibition of HSV-1 replication. The ethanolic extract exhibited a higher toxicity level than the aqueous extract, as well as the potential to induce DNA fragmentation by intrinsic and extrinsic apoptosis pathways on the Caco-2 cells. These findings suggest that red jasmine rice extract demonstrates nutritional value and biological activity on HSV, free radicals, and cancer cell inhibition. Full article
(This article belongs to the Special Issue Anthocyanins and Human Health)
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Article
Cyanidin-3-O-Glucoside Supplement Improves Sperm Quality and Spermatogenesis in a Mice Model of Ulcerative Colitis
Nutrients 2022, 14(5), 984; https://doi.org/10.3390/nu14050984 - 25 Feb 2022
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Abstract
Impaired fertility and low sperm quality are the global health problem with high attention. It has been noted that inflammation may impact fertility by affecting testicular spermatogenesis. Cyanidin-3-O-glucoside is a natural functional pigment with various health benefits. Nevertheless, studies on the [...] Read more.
Impaired fertility and low sperm quality are the global health problem with high attention. It has been noted that inflammation may impact fertility by affecting testicular spermatogenesis. Cyanidin-3-O-glucoside is a natural functional pigment with various health benefits. Nevertheless, studies on the mechanism by which C3G protects male reproduction in mice with ulcerative colitis remain scarce. The purpose of this study is to illustrate the potential mechanism of C3G for improving impaired fertility caused by colitis. A DSS-induced colitis model was applied to assess the effects of sperm quality with colitis and the health benefit role of C3G. Results indicated that C3G-treated mice exhibited higher body weight, longer colon length, less crypt damage and focal inflammation infiltration. Being consistent with that, low sperm count, low testis weight, high inflammation levels and abnormal thickness of seminiferous epithelium also observed in the DSS group were significantly recovered upon C3G treatment. These findings suggested that colitis has a close link to impaired fertility. Further analysis found that C3G could significantly suppress the inflammatory mediators in serum. Results conjointly indicated that C3G might improve the impaired fertility of mice with colitis by inhibiting inflammatory cytokines through the blood–testis barrier. C3G could be a promising daily supplement for ameliorating impaired fertility caused by colitis. Full article
(This article belongs to the Special Issue Anthocyanins and Human Health)
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