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Nutrients
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Hot Topics in Clinical Nutrition (3rd Edition)
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Hot Topics in Clinical Nutrition (3rd Edition)

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Clinical Nutrition".

Deadline for manuscript submissions: 5 August 2025 | Viewed by 4472

Special Issue Editors

Prof. Dr. Antonio Gasbarrini

grade E-Mail Website1 Website2
Guest Editor
1. Department of Translational Medicine and Surgery, School of Medicine, Catholic University, 00168 Rome, Italy
2. Center for Diagnosis and Treatment of Digestive Diseases, CEMAD, Gastroenterology Department, Fondazione Policlinico Gemelli, IRCCS, 00168 Rome, Italy
Interests: gastroenterology; oncology; digestive cancer; diverticular disease; cancer prevention; inflammatory bowel diseases; microbial communities; bioinformatics and computational biology
Special Issues, Collections and Topics in MDPI journals
Dr. Emanuele Rinninella

E-Mail Website
Guest Editor
1. Research and Training Center in Human Nutrition, Catholic University of Sacred Heart, 00168 Rome, Italy
2. Clinical Nutrition Unit, Fondazione Policlinico Universitario A. Gemelli, IRCCS, 00168 Rome, Italy
Interests: clinical nutrition; perioperative nutrition; body composition; gut microbiota dietary modulation; digestive cancer
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Following the success of the two previous Special Issues of collections of papers focusing on "Hot Topics in Clinical Nutrition", we would like to arrange another platform for scientific contributions on the matter, in order to showcase new breakthrough articles in clinical nutrition science. This Special Issue maintains the same editorial line as the previous two. The modulation of gut microbiota and related health issues, such as metabolic, inflammatory, and neoplastic diseases, and the impact of novel foods (including artificial foods) as well as additive and processed foods on human health are arguments of interest. Moreover, articles debating the role of nutritional support in disease-related malnutrition (due to cancer or acute and chronic inflammation) and perioperative nutrition are welcomed, as are manuscripts concerning the role of food waste (and environmental consequences) and strategies to deal with it. Original studies as well as meta-analyses/systematic reviews or well-prepared narratives are welcomed.

Prof. Dr. Antonio Gasbarrini
Dr. Emanuele Rinninella
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • gut microbiota
  • food additives
  • novel foods, artificial foods
  • processed foods
  • non-communicable diseases
  • cancer
  • malnutrition
  • food wasting
  • environment
  • ERAS (enhanced recovery after surgery)
  • nutritional support

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Research

17 pages, 18261 KiB  
Article
Reactive Dicarbonyl Scavenging with 2-Hydroxybenzylamine Improves MASH
by Joyce Cheung-Flynn, John A. Rathmacher, Lisa M. Pitchford, Yanhua Xiong and Charles Robert Flynn
Nutrients 2025, 17(4), 610; https://doi.org/10.3390/nu17040610 - 7 Feb 2025
Viewed by 2749
Abstract
Background: Products of lipid peroxidation include a number of reactive lipid aldehydes including reactive dicarbonyl electrophiles (DEs) and contribute to disease processes. DEs play a significant role in the development and progression of metabolic-associated steatotic liver disease (MASLD) by contributing to oxidative stress, [...] Read more.
Background: Products of lipid peroxidation include a number of reactive lipid aldehydes including reactive dicarbonyl electrophiles (DEs) and contribute to disease processes. DEs play a significant role in the development and progression of metabolic-associated steatotic liver disease (MASLD) by contributing to oxidative stress, inflammation, protein dysfunction, and mitochondrial impairment. Reducing DE stress may be a potential strategy for managing MASLD. We hypothesized that the DE scavenger 2-hydroxybenzylamine (2-HOBA) would reduce liver injury by reducing liver protein adduct formation by DE in mouse models of MASLD. Methods: Protein adducts were measured in human livers by immunohistochemistry and immunoblot. The effects of 2-HOBA were assessed in two different mouse models of MASLD. Results: Isolevuglandin (IsoLG) protein adducts were increased in MASH-staged human livers relative to histologically normal controls. Diet-Induced Animal Model of Nonalcoholic Fatty Liver Disease (DIAMOND) mice treated with 2-HOBA exhibited significantly lower fibrosis scores (* p = 0.012) and reduced liver transaminases (AST, p = 0.03) and ALT, p = 0.012) by over 40%. In STAM (Stelic Animal Model) mice, 2-HOBA improved NAFLD activity scores (p = 0.03, NAS), hyperglycemia, and inflammatory cytokines and reduced serum F2-isoprostanes (IsoPs) by 30%, p = 0.05. These improvements were absent mRNA changes in hepatic antioxidant enzymes (Cat, Gpx1, or Sod2) or ROS-generating proteins (p22PHOX, p47PHOX, NOX4 or COX1). Conclusions: DE scavenging with 2-HOBA may be a promising therapeutic strategy for managing MASLD. While findings are currently limited to male mice, a nutraceutical that reduces liver fibrosis could significantly improve the management of MASH by offering a non-invasive treatment option to potentially slow or reverse liver scarring, delay progression to cirrhosis, and improve patient outcomes, while also providing a potential treatment option for patients who may not be suitable for other interventions like liver transplantation. Full article
(This article belongs to the Special Issue Hot Topics in Clinical Nutrition (3rd Edition))
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11 pages, 526 KiB  
Article
Prescribed Hospital Diet Influence on Dietary Intake of Hospitalised Patients: A Cross-Sectional Study
by Joana Gameiro, Raquel Oliveira, Ana Lúcia Baltazar, Clara Rocha, Marta Pereira, Diana Martins, João P. M. Lima and Fernando Mendes
Nutrients 2025, 17(2), 261; https://doi.org/10.3390/nu17020261 - 12 Jan 2025
Viewed by 1442
Abstract
Background: The dietary intake of hospitalised patients is often compromised during hospitalisation, which can be a causal factor for hospital malnutrition. This is considered a public health problem worldwide and is associated with an increased risk of other complications. Objectives: Our objective was [...] Read more.
Background: The dietary intake of hospitalised patients is often compromised during hospitalisation, which can be a causal factor for hospital malnutrition. This is considered a public health problem worldwide and is associated with an increased risk of other complications. Objectives: Our objective was to determine the dietary intake of hospitalised individuals and if the prescribed diet influences it. Methods: Food intake data were collected from 299 lunches of patients admitted to a hospital, using the visual estimation method with a five-point scale. Three existing diets were considered, and the energy and macronutrient values of the meal were calculated. The minimum energy and protein requirements were also calculated. Results: The components of the tray with the highest intake were soup and dessert; no significant differences were found between the percentage intake of each element and the prescribed diet. More than 50% of the individuals did not meet their minimum energy requirements, and only 36.5% had a protein intake that was within the recommendations. Conclusions: Dietary intake is much lower than prescribed, and nutritionists need to act to reduce the prevalence of hospital malnutrition. Full article
(This article belongs to the Special Issue Hot Topics in Clinical Nutrition (3rd Edition))
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