Advanced Explorations of L-Arginine-Nitric Oxide and Nitrate-Nitrite-Nitric Oxide Pathways in Vascular and Metabolic Health

Dear Colleagues, 

Nitric oxide (NO) is main vasodilator produced in the endothelium via the L-arginine-NO pathway. Advancing age, obesity, hypertension, and type 2 diabetes are characterized by attenuated endothelium-dependent vasodilation. Endothelial dysfunction preceeds the development of arterial stiffening, atherosclerosis, hypertension, and cardiovascular diseases. NO bioavailavility for vasodilation can be improved via the L-arginine-NO and nitrate-nitrite-NO pathways. Oral supplementation of L-arginine and L-arginine precursors as well as dietary sources of L-arginine, L-citrulline, and nitrates have been used to increase NO availability and potentially improve vascular and metabolic health. However, more evidence on the vascular and metabolic effects of these NO precursors and donors require further research. With this Special Issue, we hope to encourage submissions of original articles, meta-analyses, and reviews covering novel findings on endothelial dysfunction, with a focus on emerging CV risk factors, the L-arginine-NO and nitrate-nitrite-NO pathways, and related metabolic pathways.

We look forward to receiving your submission.

Prof. Dr. Arturo Figueroa
Dr. Yejin Kang
Guest Editors

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