Malnutrition–Sarcopenia Connection in Patients with Chronic Kidney Disease
A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Clinical Nutrition".
Deadline for manuscript submissions: 25 February 2026 | Viewed by 22
Special Issue Editors
Interests: chronic renal disease progression; malnutriotion and sarcopenia in CKD
Special Issues, Collections and Topics in MDPI journals
Interests: diet in nephology; glomerulonephritis; immunity and inflammatory processes in renal diseases; hemodialysis; kidney transplantation
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
In CKD patients, malnutrition and sarcopenia prevalence increases with disease progression, driven by shared pathophysiological mechanisms, and recent research highlights systemic inflammation and nutritional deficiencies as key contributors. Intrdyalitic protein losses as well as uremic toxins and increased system inflammation promote muscle protein degradation and inhibit synthesis, intensifying muscle wasting. Concurrent malnutrition, especially protein–energy wasting and inadequate calories and amino acid intake, further accelerates muscle loss. Personalized interventions, including amino acids supplementation and omega-3 fatty acids, show promise in reducing inflammation and preserving muscle mass.
Futhermore, emerging evidence underscores the importance of the gut–muscle axis; alterations in gut microbiota in CKD are linked to systemic inflammation and muscular deterioration. Probiotics and prebiotics are being explored as potential strategies to restore gut homeostasis and mitigate muscle wasting.
Additionally, the interconnection of malnutrition, inflammation, and mineral bone disorders suggests a broader entity called “osteosarcopenia.”
This Special Issue of Nutrients aims to examine epidemiological relationships and therapeutic strategies, including dietary approaches (low-protein, vegetarian, and ketogenic diets), nutritional supplements, and nutritional approaches combined with lifestyle changes or pharmacological or dialytic interventions, to better manage malnutrition and sarcopenia in CKD patients.
Dr. Simone Vettoretti
Dr. Pasquale Esposito
Guest Editors
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Keywords
- chronic kidney disease
- malnutrition
- sarcopenia
- osteosarcopenia
- inflammation and malnutrition
- dietary interventions in CKD
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