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Nutritional Interventions for Neurodegenerative Disorders

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Clinical Nutrition".

Deadline for manuscript submissions: closed (15 February 2025) | Viewed by 1570

Special Issue Editors


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Guest Editor
Drug Discovery Laboratory, The Azrieli Faculty of Medicine, Bar-Ilan University, Safed 1311502, Israel
Interests: Alzheimer's disease; neurodegeneration; behavioral neuroscience; cognitive neuroscience; neurodegenerative diseases

E-Mail Website
Guest Editor
The Azrieli Faculty of Medicine, Bar-Ilan University, Safed 1311502, Israel
Interests: neurodegenerative diseases

Special Issue Information

Dear Colleagues,

Neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, are characterized by the progressive loss of neurons in the brain. While the exact causes of these diseases are not fully understood, there is growing evidence to suggest that nutritional factors play a role in their development and progression.

Several studies have highlighted the potential of dietary interventions in protecting against age-related cognitive decline and neurodegeneration. Lifestyle strategies, including nutritional interventions, have been shown to be safe, cost-effective, and effective in preventing and reducing cognitive decline. These interventions can have significant personal and societal benefits.

The role of nutrition in neurodegeneration is intricate and multifaceted. Although specific dietary patterns and nutrients have exhibited potential in preventing and mitigating cognitive decline and neurodegeneration, additional research is required to comprehensively grasp the underlying mechanisms and formulate effective nutritional interventions.

This Special Issue aims to include manuscripts that focus on nutrition, diet, nutritional treatment, and/or weight status in relation to the prevention and treatment of neurodegenerative diseases. The presented materials are the result of the international scientific cooperation of experts specializing in these issues. We hope that this Special Issue will be useful for clinical practitioners and inspire further innovative research.

Dr. Baruh Polis
Dr. Abraham O. Samson
Guest Editors

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Keywords

  • neurodegeneration
  • dietary approach
  • Alzheimer’s disease
  • nutrition

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Published Papers (1 paper)

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18 pages, 2366 KiB  
Systematic Review
Evidence-Based Nutritional Recommendations for Maintaining or Restoring Nutritional Status in Patients with Amyotrophic Lateral Sclerosis: A Systematic Review
by Mariana Dantas de Carvalho Vilar, Karla Monica Dantas Coutinho, Sancha Helena de Lima Vale, Mario Emilio Teixeira Dourado Junior, Gidyenne Christine Bandeira Silva de Medeiros, Grasiela Piuvezam, Jose Brandao-Neto and Lucia Leite-Lais
Nutrients 2025, 17(5), 782; https://doi.org/10.3390/nu17050782 - 24 Feb 2025
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Abstract
Background/Objectives: This study is a systematic review of guidelines that aims to synthesize evidence-based recommendations to support appropriate nutritional management for patients with amyotrophic lateral sclerosis (ALS). Methods: PubMed/MEDLINE, Embase, Scopus, SciELO, Web of Science, LILACS, ScienceDirect, and Google Scholar were [...] Read more.
Background/Objectives: This study is a systematic review of guidelines that aims to synthesize evidence-based recommendations to support appropriate nutritional management for patients with amyotrophic lateral sclerosis (ALS). Methods: PubMed/MEDLINE, Embase, Scopus, SciELO, Web of Science, LILACS, ScienceDirect, and Google Scholar were searched for records published up to July 2024. Clinical practice guidelines addressing any aspect of nutritional intervention in ALS were included. No language or country of publication restrictions were applied. Data extraction was performed by two independent reviewers. The methodological quality of the reports was assessed using the AGREE II instrument. Discrepancies were resolved by consensus. Results: The findings and main recommendations were summarized narratively. A total of 837 records were identified, and 11 were included in this review. The overall AGREE II scores for the included studies ranged from 3 to 7. The summary of nutritional recommendations was organized into topics: (1) dysphagia, (2) nutritional assessment, (3) energy, (4) protein, (5) supplementation, and (6) percutaneous endoscopic gastrostomy (PEG). This review summarizes relevant and updated nutritional recommendations to maintain or restore the nutritional status of patients with ALS, contributing to their quality of life and survival time. Conclusions: These nutritional recommendations will help health professionals and caregivers to implement and standardize nutritional care according to evidence-based practice in ALS. PROSPERO registration number CRD42021233088. Full article
(This article belongs to the Special Issue Nutritional Interventions for Neurodegenerative Disorders)
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