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The Effect of Plant Extracts on Metabolic Syndrome

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Phytochemicals and Human Health".

Deadline for manuscript submissions: 20 June 2025 | Viewed by 1167

Special Issue Editors


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Guest Editor
Department of Pharmacy, Università degli Studi di Napoli Federico II, Napoli, Italy
Interests: oxidative stress; food supplements; functional food ingredients; polyphenols; biological activity; in vitro bioaccessibility and bioavailability
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Pharmacy, University of Napoli Federico II, Via D. Montesano 49, 80131 Naples, NA, Italy
Interests: food supplements; functional food ingredients; polyphenols; biological activity; in vitro bioaccessibility and bioavailability
Special Issues, Collections and Topics in MDPI journals

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Guest Editor Assistant
Department of Experimental Medicine, Section of Microbiology and Clinical Microbiology, University of Campania “L. Vanvitelli”, 80138 Naples, Italy
Interests: food supplements; functional food ingredients; polyphenols; biological activity; in vitro bioaccessibility and bioavailability

Special Issue Information

Dear Colleagues,

The global interest in plant-based therapies and nutraceuticals has surged, driven by their potential to promote health and prevent disease. This Special Issue will focus on the health benefits of plant extracts, emphasizing their bioactive compounds, mechanisms of action, and clinical relevance.

Plant extracts contain a diverse range of phytochemicals, such as polyphenols, alkaloids, flavonoids, and terpenoids, which have demonstrated antioxidant, anti-inflammatory, antimicrobial, and other bioactive properties. Emerging research highlights their role in mitigating chronic diseases, including cardiovascular, neurodegenerative, metabolic, and inflammatory disorders. This Special Issue aims to provide a comprehensive platform for advancing the understanding of plant extracts as functional ingredients in nutrition, medicine, and health promotion.

We invite original research articles, systematic reviews, and meta-analyses exploring the isolation, characterization, and health impacts of plant-derived compounds. Studies addressing challenges in bioavailability, synergistic effects, and innovative delivery systems are also encouraged. By bridging traditional knowledge and modern science, this Special Issue will contribute to a deeper insight into the therapeutic potential of plant extracts, fostering evidence-based applications in health and wellness.

Dr. Alessandro Di Minno
Prof. Dr. Maria Daglia
Dr. Hammad Ullah
Guest Editors

Dr. Maria Vittoria Morone
Guest Editor Assistant

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • plant extracts
  • plant-based therapeutics
  • phytochemicals
  • bioactive compounds
  • nutraceuticals
  • functional foods
  • antioxidants
  • anti-inflammatory properties
  • chronic disease prevention
  • cardiovascular health
  • neuroprotective effects
  • metabolic health
  • bioavailability

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Published Papers (1 paper)

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Research

17 pages, 2172 KiB  
Article
Isoschaftoside in Fig Leaf Tea Alleviates Nonalcoholic Fatty Liver Disease in Mice via the Regulation of Macrophage Polarity
by Tatsuya Abe
Nutrients 2025, 17(5), 757; https://doi.org/10.3390/nu17050757 - 21 Feb 2025
Viewed by 776
Abstract
Background: Nonalcoholic fatty liver disease (NAFLD) is a subset of fatty liver disease that is not caused by alcohol or viruses, and its increasing incidence presents a major global health concern. As few pharmacotherapies are available for NAFLD, lifestyle modifications, including diet and [...] Read more.
Background: Nonalcoholic fatty liver disease (NAFLD) is a subset of fatty liver disease that is not caused by alcohol or viruses, and its increasing incidence presents a major global health concern. As few pharmacotherapies are available for NAFLD, lifestyle modifications, including diet and exercise, serve as the foundation for treatment. Therefore, NAFLD prevention is more important than cure, emphasizing the need for drugs with excellent safety and long-term efficacy. Fig leaf tea contains rutin and isoschaftoside (ISS), which may possess anti-inflammatory properties. Therefore, the aim of this murine-model-based study was to investigate the potential benefits of fig leaf tea in alleviating NAFLD and to determine the underlying mechanism by gene expression analysis. Results: We found that in mice with NAFLD induced by a high-fat diet, the administration of high concentration fig leaf tea or 50 µM ISS significantly ameliorated lobule inflammation. In contrast, low concentration fig leaf tea containing 75 µM ISS did not improve inflammation. The balance between the NAFLD-promoting component of fig leaf tea and the inhibitory effect of ISS was thought to be affected. Gene expression analysis of the liver showed that high concentration fig leaf tea or ISS significantly suppressed the expression of M1 macrophage markers such as CD antigens, toll-like receptors (TLR), chemokines, and cytokines. Further, ISS suppressed the amount of TNF-α released during the M1 polarization of macrophage cells upon lipopolysaccharide (LPS) stimulation. Conclusions: Overall, these results suggest that controlling macrophage polarization may improve NAFLD. Furthermore, these findings highlight the potential clinical applicability of ISS. Full article
(This article belongs to the Special Issue The Effect of Plant Extracts on Metabolic Syndrome)
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