Natural Bioactives in the Arsenal Against Neurological and Neurodegenerative Disorders Towards Healthy Ageing

Dear Colleagues,

Advanced ageing of our modern society is the primary risk factor for the development of most neurodegenerative diseases. A key factor in neurodegenerative diseases like Alzheimer's and Parkinson's is oxidative stress. Excess reactive oxygen species (ROS) can damage cellular components like proteins, lipids, and DNA. This contributes to mitochondrial dysfunction and the buildup of misfolded proteins, leading to cellular dysfunction and ultimately to neuronal cell death. Additionally, oxidative stress can trigger an inflammatory response in the brain, further damaging brain tissue.

This Special Issue aims at the in-depth exploration and the modern interpretation of millennial-old knowledge of natural bioactive compounds' effects on the human body and brain function, both from plant, animal, fungi, or microbial sources. It will serve as a platform for discussion of the latest cutting-edge technologies merging with ancient knowledge to address the challenges of modern medicine- increasing the life- and health-span of humanity. 

Original papers, reviews, and short communications that explore the neuroprotective and anti-inflammatory potential of, but not limited to, flavonoids, polyphenols, terpenoids, and alkaloids in various neurological and neurodegenerative diseases, but also in healthy ageing, are invited.

Dr. Plamena R. Angelova
Guest Editor

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