Dose-Related Activity of Polyphenols: Physiological Interaction with Gut Microbiota

Dear Colleagues,

Polyphenols are among the most extensively studied nutritional phytochemicals due to their potential beneficial effects on human health. Over recent years, significant advancements have deepened our understanding of their mechanisms of action, bioavailability, and interactions with biological systems. One particularly dynamic area of research is the dose-dependent activity of polyphenols and their complex interplay with gut microbiota, which significantly influences their metabolism and biological effects.

This Special Issue offers a comprehensive exploration of the intricate relationships between polyphenol dosage, their bioactivities, and their modulation of gut microbial communities. Moving beyond a narrow focus on individual polyphenol compounds or isolated health outcomes, this Issue aims to provide a broad perspective on current research. Topics of interest include, but are not limited to, the following:

• Dose–response effects of polyphenols on human health outcomes.
• Biotransformation of polyphenols by gut microbiota and its impact on bioactivity.
• Reciprocal interactions between polyphenols and gut microbial composition or functionality.
• Clinical and preclinical evidence of dose-specific polyphenol effects mediated by the gut microbiome.
• Methodological advances for studying dose-dependent polyphenol–microbiota interactions.

By highlighting the synergistic and dose-specific effects of polyphenols in the context of gut microbiota, this Issue seeks to expand our understanding of their role in human health and encourage innovative research at the intersection of nutrition, microbiology, and pharmacology.

Dr. Mohamad Khalil
Prof. Dr. Piero Portincasa
Guest Editors

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