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Interaction between Polyphenols and Gut Microbiota in Cancer

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Phytochemicals and Human Health".

Deadline for manuscript submissions: closed (25 July 2024) | Viewed by 1765

Special Issue Editor


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Guest Editor
Department of Basic Health Sciences, Faculty of Health Sciences, University Rey Juan Carlos (URJC), 28922 Alcorcón, Spain
Interests: gastrointestinal motility; gastrointestinal dysmotility; intestinal cancer; IBS; IBD; functional foods

Special Issue Information

Dear Colleagues,

Dietary polyphenols are natural compounds present in plants with important biological functions. These include their antioxidant, antifungal and antibacterial properties. In vitro studies have also demonstrated their anti-inflammatory and antiproliferative effects. On the other hand, the microbiota, mainly digestive, is receiving a great deal of attention since its metabolites seem to influence an increasing number of physiological processes. This could be of vital interest for the treatment of highly prevalent pathologies such as cancer. In fact, the direct relationship between polyphenol metabolism and the digestive microbiota has been demonstrated, and the relationship between inflammatory phenomena and intestinal dysbiosis is also known. However, in vivo studies are more scarce. In any case, the variety of existing food polyphenols and pre/probiotics is very large, and more research is needed on the relationship between them and tumor transformation to find effective treatments that take advantage of their properties.

Dr. Jose Antonio Uranga
Guest Editor

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Keywords

  • microbiota
  • microbiome
  • polyphenols
  • cancer
  • inflammation
  • oxidative stress

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Published Papers (1 paper)

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15 pages, 675 KiB  
Systematic Review
Polyphenols in the Prevention and Treatment of Colorectal Cancer: A Systematic Review of Clinical Evidence
by Laura López-Gómez and Jose Antonio Uranga
Nutrients 2024, 16(16), 2735; https://doi.org/10.3390/nu16162735 - 16 Aug 2024
Viewed by 1518
Abstract
Polyphenols are plant metabolites with potential anti-inflammatory and anti-proliferative effects, which may be advantageous for disorders like colorectal cancer (CRC). Despite promising in vitro and in vivo evidence, human clinical trials have yielded mixed results. The present study aimed to evaluate the clinical [...] Read more.
Polyphenols are plant metabolites with potential anti-inflammatory and anti-proliferative effects, which may be advantageous for disorders like colorectal cancer (CRC). Despite promising in vitro and in vivo evidence, human clinical trials have yielded mixed results. The present study aimed to evaluate the clinical evidence of polyphenols for CRC prevention or treatment. A systematic review was performed according to PRISMA. Based on a PROSPERO registered protocol (CRD42024560044), online databases (PubMed and COCHRANE) were utilized for the literature search. A total of 100 studies articles were initially identified. After reviewing, 12 studies with a low risk of bias were selected, examining the effect of a variety of compounds. Curcumin demonstrated promise in various trials, mainly decreasing inflammatory cytokines, though results varied, and it did not lower intestinal adenomas or improve outcomes after chemotherapy. Neither epigallocatechin gallate nor artepillin C reduced the incidence of adenomas. Finally, fisetin seemed to improve the inflammatory status of patients under chemotherapy (5-fluorouracil). In summary, although certain polyphenols appear to exert some effect, their role in the prevention or treatment of CRC is inconclusive, and more clinical studies under more controlled conditions are needed. Full article
(This article belongs to the Special Issue Interaction between Polyphenols and Gut Microbiota in Cancer)
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