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Feature Papers from High Cited Researchers (Closed)

A topical collection in Molecules (ISSN 1420-3049).

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Editors

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Collection Editor
Groupe de Recherche en Eco-Extraction de Produits Naturel, Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement, Université d´Avignon et des Pays du Vaucluse, 84029 Avignon, France
Interests: green extraction; alternative solvents; innovative technologies; original procedures; microwave; ultrasound; intensification
* It is with great sadness that we announce the passing of Professor Farid Chemat.
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Collection Editor
Nutrition and Food Science Area, Preventive Medicine and Public Health, Food Science, Toxicology and Forensic Medicine Department, Faculty of Pharmacy, Universitat de València, Avda. Vicent Andrés Estellés, s/n, 46100 Burjassot, Valencia, Spain
Interests: nutrients; bioactive compounds; food preservation; thermal treatment; innovative processing; high-pressure processing; compressed fluids; pulsed electric fields; ultrasound; microwaves; phytochemical purification; phytochemical analysis; compound isolation; bioaccessibility; bioavailability
Special Issues, Collections and Topics in MDPI journals

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Collection Editor
School of Engineering, RMIT University, 124 La Trobe Street, Melbourne, VIC 3001, Australia
Interests: inorganic chemistry; physical chemistry; materials science; nanoscience; catalysis; chemical biology; analytical chemistry
State Key Laboratory for Mechanical Behavior of Materials, School of Materials Science and Engineering, Xi’an Jiaotong University, Xi’an 710049, China
Interests: microwave dielectric ceramics; varistors; electro-ceramics; cold sintering process

Topical Collection Information

Dear Colleagues,

The journal Molecules helps researchers disseminate their research and also provides free access to scientific and technical information.

The 2021 list of Highly Cited Researchers was recently published (https://recognition.webofscience.com/awards/highly-cited/2021/). Highly Cited Researchers, who rank in the top 1% according to citations, have been selected for their exceptional influence and performance for the period 2010–2020. They are pioneers in their field and have been recognized by their peers.

The present Topical Collection will honor Highly Cited Researchers from Molecules and invite them to contribute an article or a review in the field of the journal.

It is also an honor to have many High Cited Researchers from different disciplines serving as Editorial members (Prof. Dr. Maurizio Battino, Prof. Dr. Didier Astruc, Dr. Francisco J. Barba, Prof. Dr. Cyrille Boyer, Prof. Dr. Wei Lv, Prof. Dr. Daniel Granato, Prof. Dr. Baibiao Huang, Prof. Dr. Kourosh Kalantar-Zadeh, Dr. Yangchao Luo, Prof. Dr. Rafael Luque, Prof. Dr. Yanming Ma, Prof. Dr. Liqiang Mai) in Molecules. 

Prof. Dr. Farid Chemat
Prof. Dr. Francisco J. Barba
Dr. Nasir Mahmood
Dr. Jing Guo
Collection Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the collection website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (5 papers)

2022

Jump to: 2021

15 pages, 4086 KiB  
Article
Trident Nano-Indexing the Proteomics Table: Next-Version Clustering of Iron Carbide NPs and Protein Corona
by Murtaza Hasan, Ayesha Zafar, Maryum Jabbar, Tuba Tariq, Yasmeen Manzoor, Muhammad Mahmood Ahmed, Shahbaz Gul Hassan, Xugang Shu and Nasir Mahmood
Molecules 2022, 27(18), 5754; https://doi.org/10.3390/molecules27185754 - 6 Sep 2022
Cited by 8 | Viewed by 1688
Abstract
Protein corona composition and precise physiological understanding of differentially expressed proteins are key for identifying disease biomarkers. In this report, we presented a distinctive quantitative proteomics table of molecular cell signaling differentially expressed proteins of corona that formed on iron carbide nanoparticles (NPs). [...] Read more.
Protein corona composition and precise physiological understanding of differentially expressed proteins are key for identifying disease biomarkers. In this report, we presented a distinctive quantitative proteomics table of molecular cell signaling differentially expressed proteins of corona that formed on iron carbide nanoparticles (NPs). High-performance liquid chromatography/electrospray ionization coupled with ion trap mass analyzer (HPLC/ESI-Orbitrap) and MASCOT helped quantify 142 differentially expressed proteins. Among these proteins, 104 proteins showed upregulated behavior and 38 proteins were downregulated with respect to the control, whereas 48, 32 and 24 proteins were upregulated and 8, 9 and 21 were downregulated CW (control with unmodified NPs), CY (control with modified NPs) and WY (modified and unmodified NPs), respectively. These proteins were further categorized on behalf of their regularity, locality, molecular functionality and molecular masses using gene ontology (GO). A STRING analysis was used to target the specific range of proteins involved in metabolic pathways and molecular processing in different kinds of binding functionalities, such as RNA, DNA, ATP, ADP, GTP, GDP and calcium ion bindings. Thus, this study will help develop efficient protocols for the identification of latent biomarkers in early disease detection using protein fingerprints. Full article
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2021

Jump to: 2022

7 pages, 2002 KiB  
Perspective
Heterogeneous Catalysis to Drive the Waste-to-Pharma Concept: From Furanics to Active Pharmaceutical Ingredients
by Rafael Luque, Zeid A. ALOthman, Alina M. Balu and Leonid Voskressensky
Molecules 2021, 26(21), 6738; https://doi.org/10.3390/molecules26216738 - 8 Nov 2021
Cited by 3 | Viewed by 2387
Abstract
A perspective on the use of heterogeneous catalysis to drive the waste-to-pharma concept is provided in this contribution based on the conversion of furanics to active pharmaceutical ingredients (APIs). The provided overview of the concept in this perspective article has been exemplified for [...] Read more.
A perspective on the use of heterogeneous catalysis to drive the waste-to-pharma concept is provided in this contribution based on the conversion of furanics to active pharmaceutical ingredients (APIs). The provided overview of the concept in this perspective article has been exemplified for two key molecule examples: Ancarolol and Furosemide. Full article
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18 pages, 760 KiB  
Review
Citrus aurantium L. Active Constituents, Biological Effects and Extraction Methods. An Updated Review
by Sawssan Maksoud, Roula M. Abdel-Massih, Hiba N. Rajha, Nicolas Louka, Farid Chemat, Francisco J. Barba and Espérance Debs
Molecules 2021, 26(19), 5832; https://doi.org/10.3390/molecules26195832 - 26 Sep 2021
Cited by 33 | Viewed by 9850
Abstract
Citrus genus is a prominent staple crop globally. Long-term breeding and much hybridization engendered a myriad of species, each characterized by a specific metabolism generating different secondary metabolites. Citrus aurantium L., commonly recognized as sour or bitter orange, can exceptionally be distinguished from [...] Read more.
Citrus genus is a prominent staple crop globally. Long-term breeding and much hybridization engendered a myriad of species, each characterized by a specific metabolism generating different secondary metabolites. Citrus aurantium L., commonly recognized as sour or bitter orange, can exceptionally be distinguished from other Citrus species by unique characteristics. It is a fruit with distinctive flavor, rich in nutrients and phytochemicals which possess different health benefits. This paper presents an overview of the most recent studies done on the matter. It intends to provide an in-depth understanding of the biological activities and medicinal uses of active constituents existing in C. aurantium. Every plant part is first discussed separately with regards to its content in active constituents. All extraction methods, their concepts and yields, used to recover these valuable molecules from their original plant matrix are thoroughly reported. Full article
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19 pages, 6837 KiB  
Article
Adsorption of Crystal Violet Dye Using Activated Carbon of Lemon Wood and Activated Carbon/Fe3O4 Magnetic Nanocomposite from Aqueous Solutions: A Kinetic, Equilibrium and Thermodynamic Study
by Rauf Foroutan, Seyed Jamaleddin Peighambardoust, Seyed Hadi Peighambardoust, Mirian Pateiro and Jose M. Lorenzo
Molecules 2021, 26(8), 2241; https://doi.org/10.3390/molecules26082241 - 13 Apr 2021
Cited by 166 | Viewed by 5793
Abstract
Activated carbon prepared from lemon (Citrus limon) wood (ACL) and ACL/Fe3O4 magnetic nanocomposite were effectively used to remove the cationic dye of crystal violet (CV) from aqueous solutions. The results showed that Fe3O4 nanoparticles were [...] Read more.
Activated carbon prepared from lemon (Citrus limon) wood (ACL) and ACL/Fe3O4 magnetic nanocomposite were effectively used to remove the cationic dye of crystal violet (CV) from aqueous solutions. The results showed that Fe3O4 nanoparticles were successfully placed in the structure of ACL and the produced nanocomposites showed superior magnetic properties. It was found that pH was the most effective parameter in the CV dye adsorption and pH of 9 gave the maximum adsorption efficiency of 93.5% and 98.3% for ACL and ACL/Fe3O4, respectively. The Dubinin–Radushkevich (D-R) and Langmuir models were selected to investigate the CV dye adsorption equilibrium behavior for ACL and ACL/Fe3O4, respectively. A maximum adsorption capacity of 23.6 and 35.3 mg/g was obtained for ACL and ACL/Fe3O4, respectively indicating superior adsorption capacity of Fe3O4 nanoparticles. The kinetic data of the adsorption process followed the pseudo-second order (PSO) kinetic model, indicating that chemical mechanisms may have an effect on the CV dye adsorption. The negative values obtained for Gibb’s free energy parameter (−20 < ΔG < 0 kJ/mol) showed that the adsorption process using both types of the adsorbents was physical. Moreover, the CV dye adsorption enthalpy (ΔH) values of −45.4 for ACL and −56.9 kJ/mol for ACL/Fe3O4 were obtained indicating that the adsorption process was exothermic. Overall, ACL and ACL/Fe3O4 magnetic nanocomposites provide a novel and effective type of adsorbents to remove CV dye from the aqueous solutions. Full article
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18 pages, 9054 KiB  
Article
Efficacy of Phytochemicals Derived from Avicennia officinalis for the Management of COVID-19: A Combined In Silico and Biochemical Study
by Shafi Mahmud, Gobindo Kumar Paul, Mirola Afroze, Shirmin Islam, Swagota Briti Ray Gupt, Mamudul Hasan Razu, Suvro Biswas, Shahriar Zaman, Md. Salah Uddin, Mala Khan, Nunzio Antonio Cacciola, Talha Bin Emran, Md. Abu Saleh, Raffaele Capasso and Jesus Simal-Gandara
Molecules 2021, 26(8), 2210; https://doi.org/10.3390/molecules26082210 - 12 Apr 2021
Cited by 71 | Viewed by 4821
Abstract
The recent coronavirus disease 2019 (COVID-19) pandemic is a global threat for healthcare management and the economic system, and effective treatments against the pathogenic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus responsible for this disease have not yet progressed beyond the developmental [...] Read more.
The recent coronavirus disease 2019 (COVID-19) pandemic is a global threat for healthcare management and the economic system, and effective treatments against the pathogenic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus responsible for this disease have not yet progressed beyond the developmental phases. As drug refinement and vaccine progression require enormously broad investments of time, alternative strategies are urgently needed. In this study, we examined phytochemicals extracted from Avicennia officinalis and evaluated their potential effects against the main protease of SARS-CoV-2. The antioxidant activities of A. officinalis leaf and fruit extracts at 150 µg/mL were 95.97% and 92.48%, respectively. Furthermore, both extracts displayed low cytotoxicity levels against Artemia salina. The gas chromatography–mass spectroscopy analysis confirmed the identifies of 75 phytochemicals from both extracts, and four potent compounds, triacontane, hexacosane, methyl linoleate, and methyl palminoleate, had binding free energy values of −6.75, −6.7, −6.3, and −6.3 Kcal/mol, respectively, in complexes with the SARS-CoV-2 main protease. The active residues Cys145, Met165, Glu166, Gln189, and Arg188 in the main protease formed non-bonded interactions with the screened compounds. The root-mean-square difference (RMSD), root-mean-square fluctuations (RMSF), radius of gyration (Rg), solvent-accessible surface area (SASA), and hydrogen bond data from a molecular dynamics simulation study confirmed the docked complexes′ binding rigidity in the atomistic simulated environment. However, this study′s findings require in vitro and in vivo validation to ensure the possible inhibitory effects and pharmacological efficacy of the identified compounds. Full article
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