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Molecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Functional Materials for Small Molecule Electrocatalysis
edited by , Linlin Li and Qingxue Lai
submission deadline 31 Aug 2026 | 2 articles | Viewed by 4329 | Submission Open
Keywords: electrocatalysis; nanomaterials; electrochemical conversion of H2O; CO2 and N2
(This special issue belongs to the Section Nanochemistry)
Emerging Horizons of Hyperpolarization in Chemistry and Biomedicine
edited by
submission deadline 31 Aug 2026 | 3 articles | Viewed by 4302 | Submission Open
Keywords: hyperpolarization; NMR; MRI; low cost; SABRE; PHIP; d-DNP; isotopic enrichment
Determination of Trace Heavy Metals and Metalloids in Environmental and Food Samples, 3rd Edition submission deadline 31 Aug 2026 | 4 articles | Viewed by 4225 | Submission Open
Keywords: environmental analytical chemistry; food analytical methods; trace heavy metals and metalloids; chemical speciation; instrumental analysis; new analytical methods and techniques; sample pre-treatment; extreme environments; reviews; emerging environmental issues; emerging food issues; food and “ novel foods” ; insects; climate change and biogeochemical cycles of trace heavy metal(loid)s
(This special issue belongs to the Section Analytical Chemistry)
Advanced Nanotherapeutics: Design, Synthesis and Applications—2nd Edition submission deadline 31 Aug 2026 | 2 articles | Viewed by 4218 | Submission Open
Keywords: nanomedicine; nanodelivery systems; polymer therapeutics; polymer nanoparticles; anticancer nanomaterials; antimicrobial nanoparticles; theranostics
(This special issue belongs to the Section Nanochemistry)
Design and Application Based on Versatile Nano-Composites: Second Edition
edited by
submission deadline 31 Aug 2026 | 3 articles | Viewed by 4189 | Submission Open
Keywords: nanoparticles; nanosheets; composites; preparation; application
(This special issue belongs to the Section Nanochemistry)
Transition Metal Complexes with Bioactive Ligands
edited by
submission deadline 31 Aug 2026 | 4 articles | Viewed by 3970 | Submission Open
Keywords: transition metal complexes; DFT; QTAIM; biological activity; bioactive ligands; crystal structures
(This special issue belongs to the Section Organometallic Chemistry)
Functional Materials: Synthesis Strategies and Environmental Applications
edited by and
submission deadline 31 Aug 2026 | 5 articles | Viewed by 3516 | Submission Open
Keywords: environmental remediation; pollutant removal; materials chemistry; catalytic materials; environmental chemistry
(This special issue belongs to the Section Materials Chemistry)
Cross-Coupling Strategies for the Synthesis of Functionalized Organic Compounds
edited by Xiaobo Pang and Han-jun Ai
submission deadline 31 Aug 2026 | 2 articles | Viewed by 3169 | Submission Open
Keywords: cross-coupling; transition metal catalysis; palladium catalysis; copper catalysis; nickel catalysis; C– N bond formation; C– C bond formation; photoredox; electrochemistry; organic synthesis; functionalized molecules; catalytic mechanisms; green chemistry
(This special issue belongs to the Section Organic Chemistry)
Molecular Strategies for the Synthesis of Drug-Like Bioactives submission deadline 31 Aug 2026 | 1 articles | Viewed by 3051 | Submission Open
Keywords: drug-like bioactives; synthetic methodologies; green chemistry; multitarget ligands; PROTACs; molecular glues; biocatalysis; scaffold design; late-stage functionalization
(This special issue belongs to the Section Medicinal Chemistry)
Oxidative Stress and Antioxidants in Degenerative Conditions
edited by Eleni A. Rekka and
submission deadline 31 Aug 2026 | 3 articles | Viewed by 2946 | Submission Open
Keywords: antioxidants; oxidative stress; chronic-degenerative diseases; hormonal imbalance; anti-inflammatory activity; multi-targeting compounds
(This special issue belongs to the Section Medicinal Chemistry)
A New Perspective on the Determination and Removal of Pollutants in the Environment, 2nd Edition
edited by
submission deadline 31 Aug 2026 | 2 articles | Viewed by 2717 | Submission Open
Keywords: organic pollutants; toxic metals; wastewater; natural environment; determination methods; phytoremediation; adsorption; microplastic; toxicity; environmental risk
(This special issue belongs to the Section Green Chemistry)
Advances in Extraction, Characterization and Application of High-Value Compounds submission deadline 31 Aug 2026 | 4 articles | Viewed by 2714 | Submission Open
Keywords: bioactive compounds; green extraction techniques; optimization parameters; by-product valorization; health-promoting properties
(This special issue belongs to the Section Natural Products Chemistry)
Applications of Solid-Phase Microextraction and Related Techniques, the Second Edition
edited by
submission deadline 31 Aug 2026 | 2 articles | Viewed by 2482 | Submission Open
Keywords: solid-phase microextraction; micriextraction techniques; extraction sorbents; pharmaceutical analysis; forensic analysis; bioanalysis; environmental analysis; food analysis
(This special issue belongs to the Section Analytical Chemistry)
Antimicrobial Peptide Assemblies
edited by
submission deadline 31 Aug 2026 | 2 articles | Viewed by 2348 | Submission Open
Keywords: peptides; peptide hybrids; peptide conjugates; self-assembly; stimuli-responsiveness; antimicrobial activity
(This special issue belongs to the Section Chemical Biology)
Advances in Application of Natural Compounds in Skin Repair and Regenerative Medicine submission deadline 31 Aug 2026 | 2 articles | Viewed by 2318 | Submission Open
Keywords: angiogenesis; anti-inflammatory agents; antioxidants; drug delivery systems; growth factors; natural compounds; skin regeneration; tissue engineering; wound healing
(This special issue belongs to the Section Applied Chemistry)
Natural Bioactive Compounds: Therapeutic Potential in the Management of Chronic Diseases submission deadline 31 Aug 2026 | 1 articles | Viewed by 2299 | Submission Open
Keywords: natural bioactives; phytochemicals; polyphenols; isoprenoids; alkaloids; bioactive lipids and peptides; prebiotics; postbiotics; chronic diseases; non-communicable diseases
(This special issue belongs to the Section Natural Products Chemistry)
Recent Advances in DNA/Protein Biosensors submission deadline 31 Aug 2026 | 1 articles | Viewed by 2262 | Submission Open
Keywords: biosensors; DNA; RNA; proteins; biomarkers
(This special issue belongs to the Section Analytical Chemistry)
Progress in CO2 Storage Materials
edited by and Tianshan Xue
submission deadline 31 Aug 2026 | 1 articles | Viewed by 2227 | Submission Open
Keywords: carbon capture and storage; mineral carbonation; CO2  sorbents; metal-organic frameworks; porous polymers; catalytic conversion
Natural Product-Inspired Drug Discovery: From Molecular Design to Safety and Translational Pharmacology
edited by and Hassan Y. Ebrahim
submission deadline 31 Aug 2026 | 1 articles | Viewed by 2172 | Submission Open
Keywords: metabolism; molecular design; molecular mechanistic pathways; natural products; PKs/PDs; RNA/DNA Sequencing; toxicity/safety
(This special issue belongs to the Section Medicinal Chemistry)
Bioactive Compounds in Foods, Beverages, and By-Products and Their Functional Potential submission deadline 31 Aug 2026 | 2 articles | Viewed by 2132 | Submission Open
Keywords: bioactive compounds in foods; beverages; and/or food by-products; unconventional raw materials as a source of bioactive compounds; bioactive compounds in human health and diseases; bioactive compounds: focus on its mechanism of action; bioavailability of the bioactive compounds; studies (in silico; in vitro; vivo; and clinical) with a focus on bioactive potential; analytical techniques to identify bioactive compounds; trends and advances in bioactive compounds analysis
(This special issue belongs to the Section Food Chemistry)
Chiral Nanomaterials: Synthesis, Properties, and Applications
edited by
submission deadline 31 Aug 2026 | 1 articles | Viewed by 1821 | Submission Open
Keywords: chiral nanomaterial; property; synthesis; application
(This special issue belongs to the Section Applied Chemistry)
Modern Application of Cycloaddition Reactions: Experimental and Theoretical Research
edited by and Patricia Perez
submission deadline 31 Aug 2026 | 1 articles | Viewed by 1728 | Submission Open
Keywords: cycloaddition reactions; molecular electron density theory; density functional theory; reaction mechanism; organic synthesis; bioactive compounds; biological activity of heterocyclic compounds
(This special issue belongs to the Section Organic Chemistry)
Environmentally Friendly Technologies for Waste Processing and Recovery
edited by and Shuang Zhou
submission deadline 31 Aug 2026 | 2 articles | Viewed by 1673 | Submission Open
Keywords: green waste processing; resource recovery; industrial by-products; impurity removal; waste-to-resource conversion; sustainable materials; circular economy; environmentally friendly technologies
(This special issue belongs to the Section Green Chemistry)
Recent Advances in Nucleic-Acid Based Drugs Development submission deadline 31 Aug 2026 | 1 articles | Viewed by 1333 | Submission Open
Keywords: nucleic acids; oligonucleotide synthesis; modified nucleic acids; therapeutic applications; gene expression regulation; precision medicine; undruggable target
(This special issue belongs to the Section Medicinal Chemistry)
Natural Products and Their Derivatives with Applications in Health and Diseases
edited by and
submission deadline 31 Aug 2026 | 2 articles | Viewed by 1294 | Submission Open
Keywords: natural products; medicinal plants; bioactive compounds; biological activity; mechanism of action; drug development; dietary supplements; healthy food
(This special issue belongs to the Section Natural Products Chemistry)
Porous Carbon Materials: Preparation and Application, 2nd Edition
edited by
submission deadline 31 Aug 2026 | 1 articles | Viewed by 1292 | Submission Open
Keywords: porous carbon materials; energy storage; environmental science; sensors; adsorption; catalysis
(This special issue belongs to the Section Applied Chemistry)
Photocatalysis for Organic Pollutants Degradation
edited by and
submission deadline 31 Aug 2026 | 1 articles | Viewed by 1270 | Submission Open
Keywords: photocatalytic degradation of organic pollutants in waters; design and preparation of photocatalyst; homo- and heterogeneous photo-catalyzed process; intermediate fragments and intermediate organic pollutants; reactive oxygen species (ROS)
(This special issue belongs to the Section Photochemistry)
Research Advances in Li-Ion Battery Materials: Present and Future
edited by
submission deadline 31 Aug 2026 | 1 articles | Viewed by 1153 | Submission Open
Keywords: lithium-ion battery; anode materials; cathode materials; characterization
(This special issue belongs to the Section Applied Chemistry)
Advances in Chemical Analysis Procedures (Part III): Future Trends in Reducing the Environmental Impact submission deadline 31 Aug 2026 | 1 articles | Viewed by 1137 | Submission Open
Keywords: green approaches; analytical chemistry; instrumental analysis; sample preparation; quantitative analysis; AI; tools; metrics
(This special issue belongs to the Section Analytical Chemistry)
Molecular Dynamics for Chemical Reactions
edited by
submission deadline 31 Aug 2026 | 1 articles | Viewed by 1101 | Submission Open
Keywords: ab initio molecular dynamics; reactive dynamics; highly reactive systems
(This special issue belongs to the Section Computational and Theoretical Chemistry)
Biologically Active Molecules from Microbes and Plants
edited by
submission deadline 31 Aug 2026 | 1 articles | Viewed by 1095 | Submission Open
Keywords: isolation; structural characterization; biological profiling; biological activity; anti-inflammatory; anti-bacterial; anti-cancer; secondary metabolite; microbe; plant; natural product; drug discovery; bio-discovery
(This special issue belongs to the Section Natural Products Chemistry)
Chitosan, Chitosan Derivatives, Polysaccharides and Their Applications—3rd Edition submission deadline 31 Aug 2026 | 2 articles | Viewed by 1064 | Submission Open
Keywords: chitin; chitosan; polysaccharide; polysaccharide-based systems
(This special issue belongs to the Section Macromolecular Chemistry)
Physicochemical Interactions and Modifications of Composition, Structure and Properties During Food Processing submission deadline 31 Aug 2026 | 1 articles | Viewed by 1051 | Submission Open
Keywords: phytochemicals; bioactive compounds; functional food; food processing
(This special issue belongs to the Section Food Chemistry)
Advances in the Mass Spectrometry of Chemical and Biological Samples, 2nd Edition
edited by
submission deadline 31 Aug 2026 | 1 articles | Viewed by 1035 | Submission Open
Keywords: sample preparation; extraction; and ionization techniques; targeted and untargeted MS-based methods; high-resolution mass spectrometry (HRMS); MS-based omics; MS imaging; MS-based biomarker discovery and clinical diagnosis; MS-based drug development and toxicity monitoring; MS-based analysis of microbiome; MS in food chemistry and control; MS in forensic science; MS in cosmetic science; MS in environmental science; miniature MS systems; MS applications in nanomaterials development; MS applications in synthetic chemistry
(This special issue belongs to the Section Analytical Chemistry)
Chemical Synthesis and Biological Activity of Aromatic Amino Acid Derivatives
edited by Luigi Longobardo and
submission deadline 31 Aug 2026 | 1 articles | Viewed by 949 | Submission Open
Keywords: aminobenzoic acid; chemical synthesis; organic synthesis; structural modification; pharmacological properties; drug discovery; structure– activity relationship (sar); antimicrobial activity; anti-inflammatory agents; anticancer compounds; green chemistry; medicinal chemistry; functionalization strategies; synthetic methodologies; bioactive molecules; therapeutic potential
(This special issue belongs to the Section Organic Chemistry)
Surface Modification of Materials and Their Applications
edited by
submission deadline 31 Aug 2026 | 1 articles | Viewed by 918 | Submission Open
Keywords: chemical functionalization; surface modification; catalysis; biotechnology; advanced manufacturing; environment
(This special issue belongs to the Section Materials Chemistry)
From Functionalization to Medical Applications of Polymer Materials submission deadline 31 Aug 2026 | 1 articles | Viewed by 910 | Submission Open
Keywords: polymer functionalization; medical applications; drug delivery; tissue engineering; theranostic medicine
(This special issue belongs to the Section Materials Chemistry)
Radiolabeled Nanoparticles: Molecular Design, Targeting, Therapy, and Imaging
edited by Yuichiro Kadonaga and
submission deadline 31 Aug 2026 | 1 articles | Viewed by 889 | Submission Open
Keywords: synthesis of radiolabeled nanoparticles; biological evaluation of radiolabeled nanoparticles; theranostics; drug delivery; surface modification of nanoparticles; structural analysis; nuclear medicine; organic chemistry; inorganic chemistry
(This special issue belongs to the Section Nanochemistry)
Synthesis, Characterization, and Biological Evaluation of Small Molecules as Anticancer Agents
edited by
submission deadline 31 Aug 2026 | 2 articles | Viewed by 877 | Submission Open
Keywords: anticancer small molecules; medicinal chemistry; drug design and synthesis; structure– activity relationship; targeted therapy; apoptosis induction; preclinical evaluation
(This special issue belongs to the Section Bioorganic Chemistry)
Peptide and Protein Folding submission deadline 31 Aug 2026 | 1 articles | Viewed by 838 | Submission Open
Keywords: peptide structure and dynamics; disulfide bond formation; folding pathways and intermediates; protein stability and misfolding; machine learning in structural biology
(This special issue belongs to the Section Chemical Biology)
Aroma and Volatile Compounds from Foods
edited by
submission deadline 31 Aug 2026 | 1 articles | Viewed by 824 | Submission Open
Keywords: aroma compounds; volatile organic compounds (VOCs); food flavor; gas chromatography– mass spectrometry (GC-MS); odor activity value (OAV); food quality; food processing; sensory analysis
(This special issue belongs to the Section Flavours and Fragrances)
Synthesis and Applications of Nanoparticles and Multifunctional Nanocomposites, 2nd Edition
edited by Iulia Ioana Lungu and
submission deadline 31 Aug 2026 | 1 articles | Viewed by 823 | Submission Open
Keywords: nanoparticles; nanocomposites; synthesis; multifunctional platforms
(This special issue belongs to the Section Nanochemistry)
Recent Advances in Supramolecular and Surface Photochemistry submission deadline 31 Aug 2026 | 1 articles | Viewed by 815 | Submission Open
Keywords: supramolecular photochemistry; organic photochemistry; photochemical synthesis; medicinal uses of photochemistry; biomolecular photochemistry; photochemical reaction mechanisms; photochemistry in confined spaces
(This special issue belongs to the Section Photochemistry)
Novel Strategies in Drug Discovery of Parasitic Diseases submission deadline 31 Aug 2026 | 1 articles | Viewed by 770 | Submission Open
Keywords: parasitic diseases; drug discovery; antiparasitic agents; drug resistance; molecular targets; natural products; computational drug design; drug repurposing
(This special issue belongs to the Section Medicinal Chemistry)
Photocatalytic Water Splitting: Cutting-Edge Research and Future Directions
edited by
submission deadline 31 Aug 2026 | 1 articles | Viewed by 744 | Submission Open
Keywords: photocatalytic water splitting; hydrogen production; photocatalysts; heterojunctions; co-catalysts; charge carrier
(This special issue belongs to the Section Photochemistry)
One Health Drugs Against Vector-Borne Parasitic Diseases—a Sustainable Chemical/Biological Approach submission deadline 31 Aug 2026 | Viewed by 705 | Submission Open
Keywords: vector-borne diseases; parasitic diseases; antiparasitic drugs; transmission-blocking drugs; chemotherapy; drug resistance; drug repurposing; pharmacokinetics; natural products; organic production; host-directed therapy; combination therapy; in vitro/in vivo models; drug delivery systems; nanomedicine; pharmacodynamics
(This special issue belongs to the Section Medicinal Chemistry)
Natural and Synthetic Bioactive Compounds in Food—Risks and Benefits
edited by
submission deadline 31 Aug 2026 | 1 articles | Viewed by 655 | Submission Open
Keywords: bioactive compounds; health; safety; effects; toxicology; biology; food; feed
(This special issue belongs to the Section Medicinal Chemistry)
Biomass-Derived Materials: From Molecular Design to Sustainable Applications submission deadline 31 Aug 2026 | 1 articles | Viewed by 635 | Submission Open
Keywords: biomass-derived materials; renewable feedstocks; molecular design; green synthesis; sustainable materials; biopolymers; biochars and activated carbons; functional composites; circular economy
(This special issue belongs to the Section Green Chemistry)
Exploring Agri-Food By-Products: From Novel Extraction to Bioactive Properties
edited by
submission deadline 31 Aug 2026 | 1 articles | Viewed by 625 | Submission Open
Keywords: agri-food by-products; bioactive compounds; novel extraction methods; phytochemicals; antioxidant properties
(This special issue belongs to the Section Food Chemistry)
Dietary Bioactive Compounds: Analytical Challenges and Health Perspectives
edited by
submission deadline 31 Aug 2026 | 1 articles | Viewed by 620 | Submission Open
Keywords: dietary bioactive compounds; analytical methods; bioaccessibility; bioavailability; functional foods
(This special issue belongs to the Section Food Chemistry)
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