Natural Bioactive Compounds: Therapeutic Potential in the Management of Chronic Diseases
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".
Deadline for manuscript submissions: 31 July 2025 | Viewed by 144
Special Issue Editor
Interests: dietary antioxidants; phytochemicals; polyphenols; flavonoids and their derivatives; chemoprevention; molecular mechanisms of action; DNA damage signaling and DNA repair; postbiotics of polyphenols
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Chronic diseases, including diabetes, cardiovascular diseases, cancer, and neurodegenerative disorders, are among the leading causes of morbidity and mortality worldwide. These conditions often stem from a combination of genetic, environmental, and lifestyle factors. In recent years, natural bioactive compounds have gained significant attention for their therapeutic potential in preventing and managing chronic diseases. These compounds, derived from plants, animals, and microorganisms, exhibit a wide range of biological activities, including antioxidant, anti-inflammatory, antimicrobial, and anticancer properties.
The therapeutic effects of natural bioactive compounds are largely attributed to their ability to modulate various biochemical and molecular pathways. Their key mechanisms include antioxidant activity, anti-inflammatory activity, modulation of gut microbiota, regulation of metabolism and intercellular signaling, induction of apoptosis of cancer cells, and regulation of immune responses. Natural bioactive compounds hold immense promises for the prevention and management of chronic diseases. By targeting multiple pathways, these compounds offer a holistic approach to health. However, translating their potential into effective therapies requires addressing challenges related to bioavailability, stability, and standardization.
Original research and review articles are welcome to discuss the advancement of our knowledge within the prevention and therapeutic potential of natural bioactive compounds in the management of chronic diseases, the interaction of these compounds with gut microbiota, and approaches to enhance their stability, bioavailability, and bioefficacy.
Prof. Dr. H. P. Vasantha Rupasinghe
Guest Editor
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Keywords
- natural bioactives
- phytochemicals
- polyphenols
- isoprenoids
- alkaloids
- bioactive lipids and peptides
- prebiotics
- postbiotics
- chronic diseases
- non-communicable diseases
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