Advances in Application of Natural Compounds in Skin Repair and Regenerative Medicine
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Applied Chemistry".
Deadline for manuscript submissions: 31 August 2026 | Viewed by 5
Special Issue Editor
Interests: hyaluronan; reactive oxygen species; drugs; antioxidants; biopolymers
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleague,
Natural compounds play a crucial role in promoting wound healing and skin regeneration by modulating key cellular and molecular processes involved in tissue repair. Naturally derived molecules, including polysaccharides, peptides, polyphenols, vitamins, and growth factors, can stimulate multiple phases of wound healing, such as hemostasis, inflammation resolution, re-epithelialization, angiogenesis, and extracellular matrix remodeling.
Antioxidant and anti-inflammatory natural compounds help mitigate oxidative stress and chronic inflammation, while antimicrobial natural compounds contribute to infection prevention in both acute and chronic wounds. When incorporated into advanced delivery systems—such as hydrogels, nanofibers, scaffolds, and films—natural compounds can be protected from degradation, precisely targeted, and released in a controlled manner at the wound site, enhancing stability and therapeutic efficacy.
Current research also emphasizes the development of cell-instructive materials incorporating natural compounds that provide biochemical and biophysical cues to guide stem cell recruitment and differentiation, enabling true tissue regeneration rather than simple wound closure. This Special Issue focuses on the sources, mechanisms of action, and delivery strategies of natural compounds for wound healing and skin regeneration, while highlighting current challenges and future directions toward safe, effective, and clinically translatable therapies.
Dr. Katarína Valachová
Guest Editor
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Keywords
- angiogenesis
- anti-inflammatory agents
- antioxidants
- drug delivery systems
- growth factors
- natural compounds
- skin regeneration
- tissue engineering
- wound healing
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