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Natural Products and Their Derivatives with Applications in Health and Diseases

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: 31 August 2026 | Viewed by 743

Special Issue Editors


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Guest Editor
Department of Pharmacy, School of Pharmaceutical Sciences, National Yang Ming Chiao Tung University, Taipei 11221, Taiwan
Interests: natural product chemistry; bioactive natural products; new drug R&D; translation research; cosmetic and functional food R&D; Chinese herbal medicine biotechnology
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Guest Editor Assistant
Department of Pharmacy, School of Pharmaceutical Sciences, National Yang Ming Chiao Tung University, Taipei 11221, Taiwan
Interests: antioxidants; bioactive compounds; natural products; phytochemicals

Special Issue Information

Dear Colleagues,

This Special Issue aims to provide a platform for scientists and researchers to publish original research articles, reviews, and short communications on natural products (NPs) and their derivatives with potential applications in health promotion and disease prevention.

Bioactive compounds derived from natural sources—such as medicinal plants, food, and fungi—have long played a vital role in preventing and treating human diseases. The remarkable chemical diversity and structural novelty of NPs and their derivatives continue to provide promising leads for modern drug discovery and therapeutic development. Recent advances in analytical, biological, and computational approaches further expanded their potential, enhancing efficacy, safety, and target specificity.

This Special Issue of Molecules aims to highlight recent progress in the discovery and development of bioactive natural products and their derivatives, emphasizing isolation, purification, and structural elucidation, as well as mechanistic insights obtained through experimental and computational approaches. We also welcome studies focusing on synthetic modification, structure–activity relationships, and the development of functional ingredients or drug candidates for health-related applications.

Interdisciplinary contributions bridging phytochemistry, chemistry, and pharmacology are especially welcome, as they can provide deeper insights into the mechanisms underlying the health benefits of natural products.

We look forward to your submissions. 

Prof. Dr. Jih-Jung Chen
Guest Editor

Dr. Sin-Min Li
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • natural products
  • medicinal plants
  • bioactive compounds
  • biological activity
  • mechanism of action
  • drug development
  • dietary supplements
  • healthy food

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Published Papers (1 paper)

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Review

16 pages, 557 KB  
Review
Recent Progress in the Regioselective Biotransformation and Multitarget Therapeutic Potential of Ginsenoside Rd
by Xingang Shen, Kun Ming, Hongjiao Shi, Jiawei Li, Ye Yang, Wenping Zhang, Xiuming Cui and Xiaoyan Yang
Molecules 2026, 31(7), 1201; https://doi.org/10.3390/molecules31071201 - 4 Apr 2026
Viewed by 383
Abstract
Ginsenoside Rd, a protopanaxadiol (PPD)-type tetracyclic triterpenoid saponin, has emerged as a promising bioactive constituent for multitarget therapeutic interventions. However, its natural abundance in the source plant is extremely low, making direct extraction both costly and inefficient. This review systematically summarizes the latest [...] Read more.
Ginsenoside Rd, a protopanaxadiol (PPD)-type tetracyclic triterpenoid saponin, has emerged as a promising bioactive constituent for multitarget therapeutic interventions. However, its natural abundance in the source plant is extremely low, making direct extraction both costly and inefficient. This review systematically summarizes the latest research progress on regioselective biotransformation strategies for Rd production since 2022. Furthermore, it comprehensively reviews recent advances in the diverse pharmacological activities of Rd. Beyond its well-recognized neuroprotective effects against neurological disorders including Alzheimer’s disease and Parkinson’s disease, we also highlight its antitumor activity and multitarget protective effects in liver diseases. This review provides a theoretical basis for developing Rd as a high-value nutraceutical and therapeutic candidate for systemic health. Full article
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